메뉴 건너뛰기




Volumn 6, Issue 6, 2006, Pages 500-501

17-dimethylaminoethylamino-17-demethoxygeldanamycin in patients with advanced-stage solid tumors and lymphoma: A phase I study

Author keywords

Geldanamycin analogues; Heat shock proteins; Ubiquitin proteasome pathways

Indexed keywords

17 DIMETHYLAMINOETHYLAMINO 17 DEMETHOXYGELDANAMYCIN; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

EID: 33745888997     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2006.n.034     Document Type: Article
Times cited : (13)

References (14)
  • 1
    • 23044441106 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
    • Banerji U, O'Donnell A, Scurr M, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005; 23:4152-4161.
    • (2005) J Clin Oncol , vol.23 , pp. 4152-4161
    • Banerji, U.1    O'Donnell, A.2    Scurr, M.3
  • 2
    • 20944444881 scopus 로고    scopus 로고
    • Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers
    • Ramanathan RK, Trump DL, Eiseman JL, et al. Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers. Clin Cancer Res 2005; 11:3385-3391.
    • (2005) Clin Cancer Res , vol.11 , pp. 3385-3391
    • Ramanathan, R.K.1    Trump, D.L.2    Eiseman, J.L.3
  • 3
    • 0031875042 scopus 로고    scopus 로고
    • The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to Hsp90 and shares important biologic activities with geldanamycin
    • Schulte TW, Neckers LM. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to Hsp90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 1998; 42:273-279.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 273-279
    • Schulte, T.W.1    Neckers, L.M.2
  • 4
    • 0036091221 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
    • Solit DB, Zheng FF, Drobnjak M, et al. 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res 2002; 8:986-993.
    • (2002) Clin Cancer Res , vol.8 , pp. 986-993
    • Solit, D.B.1    Zheng, F.F.2    Drobnjak, M.3
  • 5
    • 0031005361 scopus 로고    scopus 로고
    • Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
    • Stebbins CE, Russo AA, Schneider C, et al. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 1997; 89:239-250.
    • (1997) Cell , vol.89 , pp. 239-250
    • Stebbins, C.E.1    Russo, A.A.2    Schneider, C.3
  • 6
    • 0032101569 scopus 로고    scopus 로고
    • Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations
    • Egorin MJ, Rosen DM, Wolff JH, et al. Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. Cancer Res 1998; 58:2385-2396.
    • (1998) Cancer Res , vol.58 , pp. 2385-2396
    • Egorin, M.J.1    Rosen, D.M.2    Wolff, J.H.3
  • 7
    • 0034743361 scopus 로고    scopus 로고
    • Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
    • Egorin MJ, Zuhowski EG, Rosen DM, et al. Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1. Cancer Chemother Pharmacol 2001; 47:291-302.
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 291-302
    • Egorin, M.J.1    Zuhowski, E.G.2    Rosen, D.M.3
  • 8
    • 0036139023 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats
    • Egorin MJ, Lagattuta TF, Hamburger DR, et al. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 2002; 49:7-19.
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 7-19
    • Egorin, M.J.1    Lagattuta, T.F.2    Hamburger, D.R.3
  • 9
    • 0042166816 scopus 로고    scopus 로고
    • 17-DMAG (NSC 707545), a water soluble geldanamycin analog, has superior in vivo antitumor activity compared to the hsp90 inhibitor 17-AAG
    • Smith V, Sausville EA, Camalier RF. 17-DMAG (NSC 707545), a water soluble geldanamycin analog, has superior in vivo antitumor activity compared to the hsp90 inhibitor 17-AAG. Eur J Cancer 2002; 38:S60.
    • (2002) Eur J Cancer , vol.38
    • Smith, V.1    Sausville, E.A.2    Camalier, R.F.3
  • 10
    • 0036494113 scopus 로고    scopus 로고
    • Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: Down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin
    • Bonvini P, Gastaldi T, Falini B, et al. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin. Cancer Res 2002; 62:1559-1566.
    • (2002) Cancer Res , vol.62 , pp. 1559-1566
    • Bonvini, P.1    Gastaldi, T.2    Falini, B.3
  • 11
    • 0025094356 scopus 로고
    • Inhibition of tryosine phosphorylation prevents T-cell receptor-mediated signal transduction
    • June C, Fletcher M, Ledbetter J. Inhibition of tryosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc Natl Acad Sci USA 1990; 87:7722-7726.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7722-7726
    • June, C.1    Fletcher, M.2    Ledbetter, J.3
  • 12
    • 0028064940 scopus 로고
    • Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
    • Whitesell L, Mimaugh EG, DeCosta B. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994; 91:8324-8328.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8324-8328
    • Whitesell, L.1    Mimaugh, E.G.2    DeCosta, B.3
  • 13
    • 85030601120 scopus 로고    scopus 로고
    • Phase I study of 17-AAG and bortezomib in patients with relapsed or refractory acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, or non-Hodgkin's lymphoma
    • Available at: www.cancer.gov. Accessed October 24
    • Blum K. Phase I study of 17-AAG and bortezomib in patients with relapsed or refractory acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, or non-Hodgkin's lymphoma. Available at: www.cancer.gov. Accessed October 24, 2005.
    • (2005)
    • Blum, K.1
  • 14
    • 0000076189 scopus 로고    scopus 로고
    • Comparison of geldanamycin (NSC-122750) and 17-allylaminogeldanamcyin (NSC-330507D) toxicity in rats
    • Page J, Heath J, Fulton R. Comparison of geldanamycin (NSC-122750) and 17-allylaminogeldanamcyin (NSC-330507D) toxicity in rats. Proc Am Assoc Cancer Res 1997; 38:A2067.
    • (1997) Proc Am Assoc Cancer Res , vol.38
    • Page, J.1    Heath, J.2    Fulton, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.