Increasing hyperpolarized spin lifetimes through true singlet eigenstates

Science

Volumn 323, Issue 5922, 2009, Pages 1711-1714

  Warren, Warren S ^a   Jenista, Elizabeth ^a   Branca, Rosa Tamara ^a   Chen, Xin ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BUTANEDIONE; 2,3 CARBON 13 LABELED DIACETYL; UNCLASSIFIED DRUG;

HYDRATION; MOLECULAR ANALYSIS; POLARIZATION; RESONANCE;

ARTICLE; ELECTRON SPIN RESONANCE; HUMAN; HYDRATION; HYPERPOLARIZATION; IMAGE ENHANCEMENT; ISOTOPE LABELING; LIFESPAN; MAGNETIC FIELD; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION; PRIORITY JOURNAL; RADIOFREQUENCY; RADIOSENSITIVITY; SIGNAL DETECTION; SPECTRAL SENSITIVITY;

CARBON ISOTOPES; CHEMICAL PHENOMENA; DIACETYL; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SENSITIVITY AND SPECIFICITY;

EID: 63449130233     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1167693     Document Type: Article

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31. This work was supported by the NIH under grant EB02122 and by the North Carolina Biotechnology Center. We thank D. Bhattacharyya for his help in determining optimal conditions to hyperpolarize diacetyl; M. Jenista for help with calculations; T. Ribiero for his assistance in running NMR spectra; L. Bouchard for discussions of singlet character in strongly coupled systems; and S. Craig, E. Toone, D. Coltart, and M. S. Warren for particularly useful discussions on the chemistry of these compounds. A provisional patent has been submitted on this work by W.S.W. and Duke University.