Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo

Food and Chemical Toxicology

Volumn 48, Issue 1, 2010, Pages 306-313

  Huang, Pei Ling ^a   Chi, Chin Wen ^a,b   Liu, Tsung Yun ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Antioxidant; Areca catechu L.; COX 2; Procyanidin

Indexed keywords

CARRAGEENAN; CATECHIN; CYCLOOXYGENASE 2; EPICATECHIN; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROCYANIDIN; PROSTAGLANDIN E2; PROTEIN KINASE B; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BETEL NUT; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUTH CANCER; NONHUMAN; POLYMERIZATION; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; TREATMENT DURATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ARECA; BLOTTING, WESTERN; CARRAGEENAN; CELL LINE, TUMOR; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 2; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLAMMATION; MALE; NUTS; PLANT EXTRACTS; PROANTHOCYANIDINS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS;

ARECA CATECHU; PIPER BETEL; RATTUS;

EID: 72149133641     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.10.014     Document Type: Article

References (35)

1. Baxter N.J., Lilley T.H., Haslam E., and Williamson M.P. Multiple interactions between polyphenols and a salivary proline-rich protein repeat result in complexation and precipitation. Biochemistry 36 (1997) 5566-5577
2. Chen C.L., Chi C.W., and Liu T.Y. Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo. J. Toxicol. Environ. Health. A 65 (2002) 327-336
3. Deprez S., Brezillon C., Rabot S., Philippe C., Mila I., Lapierre C., and Scalbert A. Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids. J. Nutr. 130 (2000) 2733-2738
4. Deprez S., Mila I., Huneau J.F., Tome D., and Scalbert A. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxid. Redox Signal. 3 (2001) 957-967
5. Du Y., Guo H., and Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J. Agric. Food Chem. 55 (2007) 1695-1701
6. Erlejman A.G., Fraga C.G., and Oteiza P.I. Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage. Free Radic. Biol. Med. 41 (2006) 1247-1256
7. Fujii H., Yokozawa T., Kim Y.A., Tohda C., and Nonaka G. Protective effect of grape seed polyphenols against high glucose-induced oxidative stress. Biosci. Biotechnol. Biochem. 70 (2006) 2104-2111
8. Garbacki N., Tits M., Angenot L., and Damas J. Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. BMC Pharmacol. 4 (2004) 25
9. Gu L., Kelm M., Hammerstone J.F., Beecher G., Cunningham D., Vannozzi S., and Prior R.L. Fractionation of polymeric procyanidins from lowbush blueberry and quantification of procyanidins in selected foods with an optimized normal-phase HPLC-MS fluorescent detection method. J. Agric. Food Chem. 50 (2002) 4852-4860
10. Guyot S., Doco T., Souquet J., Moutounet M., and Drilleau J. Characterization of highly polymerized procyanidins in cider apple (Malus sylvestris var Kermerrien) skin and pulp. Phytochemistry 44 (1997) 351-357
11. IARC. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 85 (2004) 1-334
12. Kahle K., Huemmer W., Kempf M., Scheppach W., Erk T., and Richling E. Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J. Agric. Food Chem. 55 (2007) 10605-10614
13. Kanadzu M., Lu Y., and Morimoto K. Dual function of (-)-epigallocatechin gallate (EGCG) in healthy human lymphocytes. Cancer Lett. 241 (2006) 250-255
14. Kang N.J., Lee K.W., Lee D.E., Rogozin E.A., Bode A.M., Lee H.J., and Dong Z. Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase. J. Biol. Chem. 283 (2008) 20664-20673
15. Kuhnle G., Spencer J.P., Schroeter H., Shenoy B., Debnam E.S., Srai S.K., Rice-Evans C., and Hahn U. Epicatechin and catechin are O-methylated and glucuronidated in the small intestine. Biochem. Biophys. Res. Commun. 277 (2000) 507-512
16. Kuo C.L., Chi C.W., and Liu T.Y. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett. 203 (2004) 127-137
17. Lin S.C., Lu S.Y., Lee S.Y., Lin C.Y., Chen C.H., and Chang K.W. Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes. Int. J. Cancer 116 (2005) 526-535
18. Liu T.Y., Chen C.L., and Chi C.W. Oxidative damage to DNA induced by areca nut extract. Mutat. Res. 367 (1996) 25-31
19. Lotito S.B., Actis-Goretta L., Renart M.L., Caligiuri M., Rein D., Schmitz H.H., Steinberg F.M., Keen C.L., and Fraga C.G. Influence of oligomer chain length on the antioxidant activity of procyanidins. Biochem. Biophys. Res. Commun. 276 (2000) 945-951
20. Monagas M., Gomez-Cordoves C., Bartolome B., Laureano O., and Ricardo da Silva J.M. Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon. J. Agric. Food Chem. 51 (2003) 6475-6481
21. Nair U.J., Obe G., Friesen M., Goldberg M.T., and Bartsch H. Role of lime in the generation of reactive oxygen species from betel-quid ingredients. Environ. Health Perspect. 98 (1992) 203-205
22. Nonaka G.I., Hsu F.L., and Nishioka I. Structures of dimeric, trimeric, and tetrameric procyanidins from Areca catechu L. J. Chem. Soc., Chem. Commun. (1981) 781-783
23. Pierini R., Kroon P.A., Guyot S., Ivory K., Johnson I.T., and Belshaw N.J. Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerization. Mol. Nutr. Food Res. 52 (2008) 1399-1407
24. Rahman I., Biswas S.K., and Kirkham P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol. 72 (2006) 1439-1452
25. Raneva V., Shimasaki H., Ishida Y., Ueta N., and Niki E. Antioxidative activity of 3,4-dihydroxyphenylacetic acid and caffeic acid in rat plasma. Lipids 36 (2001) 1111-1116
26. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., and Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 26 (1999) 1231-1237
27. Sang S., Hou Z., Lambert J.D., and Yang C.S. Redox properties of tea polyphenols and related biological activities. Antioxid. Redox Signal. 7 (2005) 1704-1714
28. Steffen Y., Gruber C., Schewe T., and Sies H. Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch. Biochem. Biophys. 469 (2008) 209-219
29. Steinberg F.M., Holt R.R., Schmitz H.H., and Keen C.L. Cocoa procyanidin chain length does not determine ability to protect LDL from oxidation when monomer units are controlled. J. Nutr. Biochem. 13 (2002) 645-652
30. Sugiyama H., Akazome Y., Shoji T., Yamaguchi A., Yasue M., Kanda T., and Ohtake Y. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J. Agric. Food Chem. 55 (2007) 4604-4609
31. Terra X., Valls J., Vitrac X., Merrillon J.M., Arola L., Ardevol A., Blade C., Fernandez-Larrea J., Pujadas G., Salvado J., and Blay M. Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFκB signaling pathway. J. Agric Food Chem. 55 (2007) 4357-4365
32. Verstraeten S.V., Keen C.L., Schmitz H.H., Fraga C.G., and Oteiza P.I. Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radic. Biol. Med. 34 (2003) 84-92
33. Vinegar R., Truax J.F., Selph J.L., and Voelker F.A. Pathway of onset, development, and decay of carrageenan pleurisy in the rat. Fed. Proc. 41 (1982) 2588-2595
34. Wu Q., Yang Y., and Simon J.E. Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). Chem. Biodivers. 4 (2007) 2817-2826
35. Xie D.Y., and Dixon R.A. Proanthocyanidin biosynthesis - still more questions than answers?. Phytochemistry 66 (2005) 2127-2144