Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 30, 2009, Pages 3841-3849

  Dick Jr , Lawrence W ^a   Qiu, Difei ^a   Cheng, Kuang Chuan ^a  

^a MEDAREX INC   (United States)

Author keywords

Hydrophobic interaction chromatography; Isomerization; Monoclonal antibody; Peptide mapping; PIMT assay

Indexed keywords

ANALYTICAL METHOD; ASPARTIC ACIDS; COMPLEMENTARITY-DETERMINING REGIONS; HEAVY CHAIN; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; METHYLTRANSFERASES; PEPTIDE MAPPING; PROTEIN CHARACTERIZATION; PROTEIN DEGRADATION; SDS-PAGE;

AMINES; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DIFFUSERS (OPTICAL); ELECTRON TRANSITIONS; HYDROPHOBICITY; ISOMERIZATION; ISOMERS; MAPPING; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; PEPTIDES; SURFACE PLASMON RESONANCE;

HYDROPHOBIC CHROMATOGRAPHY;

ISOASPARTATE METHYLTRANSFERASE; ISOASPARTIC ACID; METHYLTRANSFERASE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CHROMATOGRAPHY; COMPLEMENTARITY DETERMINING REGION; ENZYME ASSAY; HEAVY CHAIN; HYDROPHOBICITY; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, AFFINITY; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; ISOASPARTIC ACID; ISOMERISM; MASS SPECTROMETRY; PEPTIDE MAPPING;

EID: 72149128484     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.09.031     Document Type: Article

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