Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35495-35506

  Chen, Jeng Haur ^a,b   Cai, Zhiwei ^a   Sheppard, David N ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; ALKALINE PH; ATP HYDROLYSIS; ATP-BINDING SITE; CHANNEL ACTIVITY; CHANNEL GATING; CRITICAL DETERMINANT; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DIMER INTERFACE; DIRECT SENSING; FLOWTHROUGH; INTRACELLULAR PH; ION CHANNEL; ION TRANSPORTS; MEMBRANE PATCH; NUCLEOTIDE-BINDING DOMAIN; SITE-DIRECTED MUTATION; SUBSTRATE-ASSISTED CATALYSIS; TRANSPORT PROTEINS; WILD TYPES;

BINDING ENERGY; BINDING SITES; ENZYME ACTIVITY; IONS;

PH EFFECTS;

TRANSMEMBRANE CONDUCTANCE REGULATOR; TRANSMEMBRANE CONDUCTANCE REGULATOR CHLORIDE CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL PH; CHANNEL GATING; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; HYDROLYSIS; ION TRANSPORT; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENSITIVITY ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CELL MEMBRANE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 72149099330     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.072678     Document Type: Article

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