Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator)

Biochemistry

Volumn 38, Issue 5, 1999, Pages 1463-1468

  Ramjeesingh, Mohabir ^a   Li, Canhui ^a   Garami, Elizabeth ^a   Huan, Ling Jun ^a   Galley, Kevin ^a   Wang, Yanchun ^a   Bear, Christine E ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CHLORIDE; ION CHANNEL; LYSINE; NUCLEOTIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CATALYSIS; CHANNEL GATING; ENZYME ACTIVITY; HYDROLYSIS; LEPIDOPTERA; MUTATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FOLDING;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALANINE; CATALYSIS; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; ION CHANNEL GATING; LYSINE; MUTATION; PROTEIN FOLDING;

EID: 0033514315     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982243y     Document Type: Article

References (33)

1. Welsh, M., Tsui, L.-C., Boat, T. F., and Beaudet, A. L. (1995) in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle D., Eds.) 7th ed, pp 3799-3876, McGraw-Hill, New York.
2. Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plausic, N., and Tsui, L. C. (1989) Science 245, 1066-1073.
3. Ko, Y. H., and Pedersen, P. L. (1997) J. Bioenerg. Biomembr. 29, 417-427.
4. Anderson, M., Berger, H., Rich, D., Gregory, R., Smith, A., and Welsh, M. (1991) Cell 67, 775-784.
5. Baukrowitz, T., Hwang, T., Nairn, A., and Gadsby, D. (1994) Neuron 12, 473-482.
6. Dousmanis, A. G., Nairn, A. C., and Gadsby, D. C. (1996) Biophys. J. 70, 127 (abstract).
7. Gunderson, K. L., and Kopito, R. R. (1995) Cell 82, 231-239.
8. Hwang, T. C., Horio, M., and Gadsby, D. C. (1993) J. Gen. Physiol. 101, 629-650.
9. Carson, M. R., Travis, S. M., and Welsh, M. J. (1995) J. Biol. Chem. 270, 1711-1717.
10. Gunderson, K. L., and Kopito, R. R. (1994) J. Biol. Chem. 269, 19349-19353.
11. Li, C., Ramjeesingh, M., Wang, W., Garami, E., Hewryk, M., Lee, D., Rommens, J. M., Galley, K., and Bear, C. E. (1996) J. Biol. Chem. 271, 28463-28468.
12. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 21449-21452.
13. Muller, M., Bakos, E., Welker, E., Varadi, A., Germann, U. A., Gottesman, M. M., Morse, B. S., Roninson, I. B., Sarkadi, B. (1996) J. Biol. Chem. 271, 1877-83.
14. Senior, A. E., and Gadsby, D. C. (1997) Semin. Cancer Biol. 8, 143-150.
15. Ko, Y. H., and Pedersen, P. (1995) J. Biol. Chem. 270, 22093-22096.
16. Randak, C., Neth, P., Auerswald, E. A., Eckerskorn, C., Assfalg-Machleidt, I., and Machleidt, W. (1997) FEBS Lett. 410, 180-186.
17. Bear, C., Li, C., Kartner, N., Bridges, R., Jensen, T., Ramjeesingh, M., and Riordan, J. (1992) Cell 68, 809-818.
18. Kartner, N., Hanrahan, J., Jensen, T., Naismith, L., Sun, S., Ackerley, C., Reyes, E., Tsui, L.-C., Rommens, J., Bear, C., and Riordan, J. (1991) Cell 64, 681-691.
19. Laemmli, U.K. (1970) Nature 227, 680-685.
20. Garty, H., Rudy, B., and Karlish, S. J. D. (1983) J. Biol. Chem. 258, 13094-13099.
21. Goldberg, A. F. X., and Miller, C. (1991) J. Membr. Biol. 124, 199-206.
22. Li, C., Ramjeesingh, M., and Bear, C. E. (1996) J. Biol. Chem. 271, 11623-11626.
23. Woodbury, D., and Miller, C. (1990) Biophys J. 58, 833-839.
24. Winter, M., Sheppard, D., Carson, M., and Welsh, M. (1994) Biophys. J. 66, 1398-1403.
25. Sugita, M., Yue, Y., Foskett, J. K. (1998) EMBO J. 17, 898-908.
26. Bear, C. E., Li, C., Galley, K., Wang, Y., Garami, E., and Ramjeesingh, M. (1997) J. Bioenerg. Biomem. 29, 465-475.
27. Urbatsch, I. L., Beaudet, L., Carrier, I., and Gros, P. (1998) Biochemistry 37, 4592-4602.
28. Hoedemaeker, F. J., Davidson, A. R., and Rose, D. R. (1998) Proteins 31, 275-286.
29. Bianchet, M. A., Ko, Y. H., Amzel, L. M., and Pedersen, P. L. (1997) J. Bioenerg. Biomembr. 29, 503-524.
30. Annereau, J. P., Wulbrand, U. A. V., Cuppens, H., Bontems, F., Tummler, B., Cassiman, J. J., and Stoven, V. (1997) FEBS Lett. 407, 303-308.
31. Ambudkar, S. V., Cardarelli, C. O., Pashinsky, I., Stein, W. D. (1997) J. Biol. Chem. 272, 21160-21166.
32. Eytan, G. D., Regev, R., Assaraf, Y. G. (1996) J. Biol. Chem. 271, 3172-3178.
33. Bishop, L., Agbayani, R., Jr., Ambudkar, S. V., Maloney, P. C., Ames, G. F. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 6953-6957.