Accelerated tryptic digestion for the analysis of biopharmaceutical monoclonal antibodies in plasma by liquid chromatography with tandem mass spectrometric detection

Journal of Chromatography A

Volumn 1217, Issue 1, 2010, Pages 57-64

  Lesur, Antoine ^a   Varesio, Emmanuel ^a   Hopfgartner, Gérard ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Accelerated tryptic digestion; Liquid chromatography; Mass spectrometry; Monoclonal antibodies; Proteins; Selected reaction monitoring

Indexed keywords

1D GEL ELECTROPHORESIS; END POINTS; FORMATION KINETICS; HEATING TEMPERATURES; HEAVY AND LIGHT CHAINS; HUMAN PLASMAS; INTERNAL STANDARDS; LABELED PROTEINS; LINEAR ION TRAP; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MICROWAVE ASSISTED DIGESTION; MONITORING MODE; MONOCLONAL ANTIBODIES (MAB); PROTEIN DIGESTION; SAMPLE PREPARATION; SELECTED REACTION MONITORING; STABLE ISOTOPES; TANDEM MASS SPECTROMETRIC DETECTION; THERAPEUTIC PROTEIN; THERMAL TRANSFER; TRIPLE QUADRUPOLE; TRYPTIC DIGESTION; TRYPTIC PEPTIDES;

ALLERGIES; AMINES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROPHORESIS; GELS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOTOPES; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; MICROWAVE IRRADIATION; MONOCLONAL ANTIBODIES; REFUSE DIGESTION; SURFACE PLASMON RESONANCE;

PEPTIDES;

ISOTOPE; MONOCLONAL ANTIBODY;

ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG DEGRADATION; DRUG LABELING; GEL ELECTROPHORESIS; HEAVY CHAIN; HYDROLYSIS; ION TRAP MASS SPECTROMETRY; ISOTOPE LABELING; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MICROWAVE IRRADIATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; TANDEM MASS SPECTROMETRY; THERMAL STIMULATION;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; HUMANS; MICROWAVES; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 72049127276     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.11.011     Document Type: Article

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