Changes to biological activity following acetylation of dendrotoxin 1 from Dendroaspis polylepis (black mamba)

Toxicon

Volumn 35, Issue 8, 1997, Pages 1263-1273

  Harvey, Alan L ^a   Rowan, Edward G ^a   Vatanpour, Hossein ^a,c   Engström, Åke ^b   Westerlund, Bengt ^b   Karlsson, Evert ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CARBACHOL; DENDROTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SNAKE VENOM;

ACETYLATION; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DRUG ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; TOXIN ANALYSIS; TOXIN STRUCTURE;

ACETIC ANHYDRIDES; ACETYLATION; ANIMALS; BRAIN; CHICKENS; ELAPID VENOMS; MODELS, MOLECULAR; POTASSIUM CHANNEL BLOCKERS; RADIOLIGAND ASSAY; RATS; SYNAPTOSOMES;

ANIMALIA; CROCODYLUS NILOTICUS; DENDROASPIS; DENDROASPIS POLYLEPIS POLYLEPIS; PANTHEROPHIS OBSOLETUS; POLYLEPIS; SERPENTES;

EID: 0030849278     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(97)00016-0     Document Type: Article

References (27)

1. Danse, J. M., Rowan, E. G., Gasparini, S., Ducancel, F., Vatanpour, H., Young, L. C., Poorheidari, G., Lajeunesse, E., Drevet, P., Menez, R., Pinkasfeldt, S., Boulain, J. C., Harvey, A. L. and Ménez, A. (1994) On the site by which α-dendrotoxin binds to voltage-dependent potassium channels: site-directed mutagenesis reveals that the lysine triplet 28-30 is not essential for binding. Federation of European Biochemistry Society Letters 356, 153-155.
2. + channels. Journal of Bioenergetics and Biomembranes 28, 231-253.
3. Dougherty, D. A. (1996) Cation π interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science 271, 163-168.
4. 1H-NMR assignment and secondary structure of black mamba dendrotoxin 1, a highly selective blocker of voltage-gated potassium channels. European Journal of Biochemistry 211, 813 820.
5. Griebenow, K. and Klibanov, A. M. (1995) Lyophilization-induced reversible changes in the secondary structure of proteins. Proceedings of the National Academy of Sciences of the U.S.A. 92, 10969-10976.
6. Harvey, A. L. (1993) Neuropharmacology of potassium channel toxins. Medical Research Reriew 13, 81-104.
7. Harvey, A. L. and Anderson, M. J. (1991) Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. In Snake Toxins, ed. A. L. Harvey, pp. 131-164. Pergamon Press, New York.
8. Harvey, A. L. and Karlsson, E. (1980) Dendrotoxin from the venom of the green mamba Dendroaspis angusticeps. A neurotoxin that enhances acetylcholine release at neuromuscular junction. Naynyn-Schmiedeberg's Archivies of Pharmacology 312, 1-6.
9. Harvey, A. L. and Karlsson, E. (1982) Protease inhibitor homologues: facilitation of acetylcholine release and interactions with prejunctional blocking toxins. British Journal of Pharmacology 77, 153-161.
10. Harvey, A. L., Marshall, D. L., De-Allie, F. A. and Strong, P. N. (1989) Interaction between dendrotoxin, a blocker of voltage-dependent potassium channels, and charybdotoxin, a blocker of calcium-activated potassium channels, at binding sites on neuronal membranes. Biochemical and Biophysical Research Communications 163, 394-397.
11. Hurst, R. S., Busch, A. E., Kavanaugh, M. P., Osborne, P. B., North, R. A. and Adelman, J. P. (1991) Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels. Molecular Pharmacology 40, 572-576.
12. Jolkkonen, M., van Giersbergen, P., Hellman, U., Wernstedt, C., Oras, A., Satyapan, N., Adem, A. and Karlsson, E. (1995) Muscarinic toxins from the black mamba Dendroaspis polylepis. European Journal of Biochemistry 234, 579-585.
13. Keil, B. (1982) Enzymic cleavage of proteins. In Methods in Protein Sequence Analysis, ed. M. Elzinga, pp. 291-304. Humana Press, Clifton, NJ.
14. Keil-Dlouha, V., Zylber, N., Imhoff, J. M., Tong, N. T. and Keil, B. (1971) Proteolytic activity of pseudotrypsin. Federation of European Biochemistry Society Letters 16, 291-295.
15. MacKinnon, R. (1991) Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 350, 232-235.
16. Majumder, K., De Biasi, M., Wang, Z. and Wible, B. (1995) Molecular cloning and functional expression of a novel potassium channel β-subunit from human atrium. Federation of European Biochemistry Society Letters 361, 13-16.
17. Mehraban, F., Black, A. R., Breeze, A. L., Green, D. G. and Dolly, O. J. (1985) A functional membraneous acceptor for dendrotoxin: solubilization of the binding component. Biochemistry Society Transactions 13, 507-508.
18. Miller, C. (1995) Hunting the pore of voltage-gated channels. Current Biology 2, 573-575.
19. Morales, M. J., Castellino, R. C., Crews, A. L., Rasmusson, R. L. and Strauss, H. C. (1995) A novel β subunit increases rate of inactivation of specific voltage-gated potassium channel a subunits. Journal of Biological Chemistry 270, 6272-6277.
20. + channel pharmacology. Trends in Pharmacological Science 13, 359-364.
21. Pongs, O. (1992b) Molecular biology of voltage-dependent potassium channels. Physiology Review 72, S69-S88.
22. +-channels altered by presence of β-subunit. Nature 369, 289-294.
23. Robertson, B., Owen, D., Stow, J., Butler, C. and Newland, C. (1996) Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. Federation of European Biochemistry Society Letters 383, 26-30.
24. Riordan, J. F. and Vallee, B. L. (1967) O-Acetyltyrosine. Methods in Enzymology 11, 570-576.
25. Skarzynski, T. (1992) Crystal structure of α-dendrotoxin from the green mamba venom and its comparison with the bovine pancreatic trypsin inhibitor. Journal of Molecular Biology 224, 671-683.
26. Sundqvist, B. and MacFarlane, R. D. (1985) Cf-Plasma desorption mass spectrometry. Mass Spectrometer Review 4, 421-460.
27. 2 at 2.0 Å resolution. Federation of European Biochemistry Society Letters 301, 159-164.