Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 379-386

  Vilchis Reyes, Miguel Angel ^a   Zentella, Alejandro ^a   Martínez Urbina, Miguel Angel ^a   Guzmán, Ángel ^a   Vargas, Omar ^a   Ramírez Apan, María Teresa ^a   Ventura Gallegos, José Luis ^a   Díaz, Eduardo ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Apoptosis; Bioisosteric replacement; CDK; Imidazo 1,2 a pyridine; Quinoline

Indexed keywords

2 METHYLIMIDAZO [1,2 A] PYRIDIN 3 YL; 2 METHYLIMIDAZO [1,2 A] PYRIDINE 2 AMINOPYRIMIDINE DERIVATIVE; 4 (2 METHYLIMIDAZO [1,2 A]PYRIDIN 3 YL) N 4 TOLYLPYRIMIDIN 2 AMINE; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; FLUORINE; HYDROGEN; METHYL GROUP; PYRIMIDINE DERIVATIVE; QUINOLIN 3 YL; QUINOLIN 4 YL; QUINOLINE DERIVATIVE; QUINOLINE SUBSTITUTED 2-AMINOPYRIMIDINE DERIVATIVES; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; HUMANS; INHIBITORY CONCENTRATION 50; PYRIDINES; PYRIMIDINES; QUINOLINES;

EID: 72049117632     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.002     Document Type: Article

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