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Volumn 59, Issue 1, 2010, Pages 123-133

Exendin-4 and exercise improve hepatic glucose homeostasis by promoting insulin signaling in diabetic rats

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXENDIN 4; GLUCAGON; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

EID: 72049099836     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.06.026     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 0005107569 scopus 로고    scopus 로고
    • Regulation of intermediary metabolism during fasting and feeding
    • DeGroot L.J., and Jameson J.L. (Eds), W.B. Saunders Co, Philadelphia
    • DeFronzo R.A., and Ferrannini E. Regulation of intermediary metabolism during fasting and feeding. In: DeGroot L.J., and Jameson J.L. (Eds). Endocrinology (2001), W.B. Saunders Co, Philadelphia 737-755
    • (2001) Endocrinology , pp. 737-755
    • DeFronzo, R.A.1    Ferrannini, E.2
  • 2
    • 0033515429 scopus 로고    scopus 로고
    • Deconstructing type 2 diabetes
    • Taylor S.I. Deconstructing type 2 diabetes. Cell 97 (1999) 9-12
    • (1999) Cell , vol.97 , pp. 9-12
    • Taylor, S.I.1
  • 3
    • 0034903710 scopus 로고    scopus 로고
    • Prevention of fat-induced insulin resistance by salicylate
    • Kim J.K., Kim Y.J., Fillmore J.J., et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108 (2001) 437-446
    • (2001) J Clin Invest , vol.108 , pp. 437-446
    • Kim, J.K.1    Kim, Y.J.2    Fillmore, J.J.3
  • 4
    • 0034687208 scopus 로고    scopus 로고
    • Diabetes: the importance of the liver
    • Rutter G.A. Diabetes: the importance of the liver. Curr Biol 10 (2000) R736-R738
    • (2000) Curr Biol , vol.10
    • Rutter, G.A.1
  • 5
    • 3042704673 scopus 로고    scopus 로고
    • Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men
    • Park S.H., Kim B.I., Yun J.W., et al. Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men. J Gastroenterol Hepatol 19 (2004) 694-698
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 694-698
    • Park, S.H.1    Kim, B.I.2    Yun, J.W.3
  • 6
    • 2542479899 scopus 로고    scopus 로고
    • Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system
    • Brubaker P.L., and Drucker D.J. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 145 (2004) 2653-2659
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 7
    • 0037929866 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats
    • Aziz A., and Anderson G.H. Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats. J Nutri 133 (2003) 2326-2330
    • (2003) J Nutri , vol.133 , pp. 2326-2330
    • Aziz, A.1    Anderson, G.H.2
  • 8
    • 34447134870 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons
    • Ma X., Bruning J., and Ashcroft F.M. Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons. J Neurosci 27 (2007) 7125-7129
    • (2007) J Neurosci , vol.27 , pp. 7125-7129
    • Ma, X.1    Bruning, J.2    Ashcroft, F.M.3
  • 9
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker D.J. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122 (2002) 531-544
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 10
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker D.J. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 26 (2003) 2929-2940
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 11
    • 15044354104 scopus 로고    scopus 로고
    • GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice
    • Hansotia T., and Drucker D.J. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regul Peptides 128 (2005) 125-134
    • (2005) Regul Peptides , vol.128 , pp. 125-134
    • Hansotia, T.1    Drucker, D.J.2
  • 12
    • 0036775170 scopus 로고    scopus 로고
    • Exendin-4 up-regulates expression of PDX-1 and hastens differentiation and maturation of human fetal pancreatic cells
    • Movassat J., Beattie G.M., Lopez A.D., and Hayek A. Exendin-4 up-regulates expression of PDX-1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocri Metab 87 (2002) 4775-4781
    • (2002) J Clin Endocri Metab , vol.87 , pp. 4775-4781
    • Movassat, J.1    Beattie, G.M.2    Lopez, A.D.3    Hayek, A.4
  • 13
    • 34249741098 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis
    • Lee Y.S., Shin S., Shigihara T., et al. Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. Diabetes 56 (2007) 1671-1679
    • (2007) Diabetes , vol.56 , pp. 1671-1679
    • Lee, Y.S.1    Shin, S.2    Shigihara, T.3
  • 14
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X., Saxena N.K., Lin S., Gupta N.A., and Anania F.A. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43 (2006) 173-181
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 15
    • 0346099389 scopus 로고    scopus 로고
    • Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle
    • Perrini S., Henriksson J., Zierath J.R., and Widegren I.U. Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle. Diabetes 53 (2004) 21-24
    • (2004) Diabetes , vol.53 , pp. 21-24
    • Perrini, S.1    Henriksson, J.2    Zierath, J.R.3    Widegren, I.U.4
  • 16
    • 3042526122 scopus 로고    scopus 로고
    • Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus
    • Heled Y., Shapiro Y., Shani Y., et al. Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus. Metabolism 53 (2004) 836-841
    • (2004) Metabolism , vol.53 , pp. 836-841
    • Heled, Y.1    Shapiro, Y.2    Shani, Y.3
  • 17
    • 33646880416 scopus 로고    scopus 로고
    • Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats
    • Chang S.P., Chen Y.H., Chang W.C., Liu I.M., and Cheng J.T. Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats. Life Sci 79 (2006) 240-246
    • (2006) Life Sci , vol.79 , pp. 240-246
    • Chang, S.P.1    Chen, Y.H.2    Chang, W.C.3    Liu, I.M.4    Cheng, J.T.5
  • 18
    • 33744480770 scopus 로고    scopus 로고
    • Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats
    • Park S., Jang J.S., Jun D.W., and Hong S.M. Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. Neuroendocrinology 82 (2005) 282-293
    • (2005) Neuroendocrinology , vol.82 , pp. 282-293
    • Park, S.1    Jang, J.S.2    Jun, D.W.3    Hong, S.M.4
  • 19
    • 33750591273 scopus 로고    scopus 로고
    • Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats
    • Flores M.B., Fernandes M.F., Ropelle E.R., et al. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes 55 (2006) 2554-2561
    • (2006) Diabetes , vol.55 , pp. 2554-2561
    • Flores, M.B.1    Fernandes, M.F.2    Ropelle, E.R.3
  • 20
    • 0030045655 scopus 로고    scopus 로고
    • Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagons like peptide-1 (7-37)
    • Hosokawa Y.A., Hosokawa H., Chen C., and Leahy J.L. Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagons like peptide-1 (7-37). J Clin Invest 97 (1996) 180-186
    • (1996) J Clin Invest , vol.97 , pp. 180-186
    • Hosokawa, Y.A.1    Hosokawa, H.2    Chen, C.3    Leahy, J.L.4
  • 21
    • 33846794850 scopus 로고    scopus 로고
    • Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats
    • Kwon D.Y., Jang J.S., Hong S.M., et al. Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Eur J Nutr 46 (2007) 44-52
    • (2007) Eur J Nutr , vol.46 , pp. 44-52
    • Kwon, D.Y.1    Jang, J.S.2    Hong, S.M.3
  • 22
    • 33747884524 scopus 로고    scopus 로고
    • Exercise and dexamethasone oppositely modulate β-cell function and survival via independent pathways in 90% pancreatectomized rats
    • Choi S.B., Jang J.S., Hong S.M., Jun D.W., and Park S. Exercise and dexamethasone oppositely modulate β-cell function and survival via independent pathways in 90% pancreatectomized rats. J Endocrinol 190 (2006) 471-482
    • (2006) J Endocrinol , vol.190 , pp. 471-482
    • Choi, S.B.1    Jang, J.S.2    Hong, S.M.3    Jun, D.W.4    Park, S.5
  • 23
    • 0027170177 scopus 로고
    • Muscle GLUT 4 protein levels and impaired triglyceride metabolism in streptozotocin diabetic rats. Effect of a high sucrose diet and fish oil supplementation
    • Sebokova E., Klimes I., Moss R., et al. Muscle GLUT 4 protein levels and impaired triglyceride metabolism in streptozotocin diabetic rats. Effect of a high sucrose diet and fish oil supplementation. Ann NY Acad Sci 683 (1993) 218-227
    • (1993) Ann NY Acad Sci , vol.683 , pp. 218-227
    • Sebokova, E.1    Klimes, I.2    Moss, R.3
  • 24
    • 33747047885 scopus 로고    scopus 로고
    • Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
    • Samuel V.T., Choi C.S., Phillips T.G., et al. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes 55 (2006) 2042-2050
    • (2006) Diabetes , vol.55 , pp. 2042-2050
    • Samuel, V.T.1    Choi, C.S.2    Phillips, T.G.3
  • 25
    • 0026563892 scopus 로고
    • Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice
    • Short M.K., Clouthier D.E., Schaefer I.M., et al. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol 12 (1992) 1007-1020
    • (1992) Mol Cell Biol , vol.12 , pp. 1007-1020
    • Short, M.K.1    Clouthier, D.E.2    Schaefer, I.M.3
  • 26
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y., Kim Y.B., Peroni O.D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3
  • 27
    • 0035861644 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside
    • Jakobsen S.N., Hardie D.G., Morrice N., and Tornqvist H.E. 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem 276 (2001) 46912-46916
    • (2001) J Biol Chem , vol.276 , pp. 46912-46916
    • Jakobsen, S.N.1    Hardie, D.G.2    Morrice, N.3    Tornqvist, H.E.4
  • 28
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S., Zhang B.B., Karkanias G., and Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8 (2002) 1376-1382
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 29
    • 18244384200 scopus 로고    scopus 로고
    • Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    • Okamoto H., Obici S., Accili D., and Rossetti L. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 115 (2005) 1314-1322
    • (2005) J Clin Invest , vol.115 , pp. 1314-1322
    • Okamoto, H.1    Obici, S.2    Accili, D.3    Rossetti, L.4
  • 30
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel A., and Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol-Endocrin Metab 285 (2003) E685-E692
    • (2003) Am J Physiol-Endocrin Metab , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 31
    • 39149089288 scopus 로고    scopus 로고
    • Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats
    • Park S., Hong S.M., and Sung S.R. Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Life Sci 82 (2008) 503-511
    • (2008) Life Sci , vol.82 , pp. 503-511
    • Park, S.1    Hong, S.M.2    Sung, S.R.3
  • 32
    • 67649643780 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action
    • Ayala J.E., Bracy D.P., James F.D., Julien B.M., Wasserman D.H., and Drucker D.J. The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action. Endocrinology 150 (2009) 1155-1164
    • (2009) Endocrinology , vol.150 , pp. 1155-1164
    • Ayala, J.E.1    Bracy, D.P.2    James, F.D.3    Julien, B.M.4    Wasserman, D.H.5    Drucker, D.J.6
  • 33
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst J.J. The physiology of glucagon-like peptide 1. Physiol Rev 87 (2007) 1409-1439
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 34
    • 43749120731 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
    • Liu Z., and Habener J.F. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283 (2008) 8723-8735
    • (2008) J Biol Chem , vol.283 , pp. 8723-8735
    • Liu, Z.1    Habener, J.F.2
  • 35
    • 33644850386 scopus 로고    scopus 로고
    • Exendin-4 promotes IRS2 signaling to mediate pancreatic beta-cell growth and function
    • Park S., Dong X., Fisher T.L., et al. Exendin-4 promotes IRS2 signaling to mediate pancreatic beta-cell growth and function. J Biol Chem 281 (2006) 1159-1168
    • (2006) J Biol Chem , vol.281 , pp. 1159-1168
    • Park, S.1    Dong, X.2    Fisher, T.L.3
  • 36
    • 33645055091 scopus 로고    scopus 로고
    • Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling
    • Canettieri G., Koo S.H., Berdeaux R., et al. Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab 2 (2005) 331-338
    • (2005) Cell Metab , vol.2 , pp. 331-338
    • Canettieri, G.1    Koo, S.H.2    Berdeaux, R.3
  • 37
    • 0038339191 scopus 로고    scopus 로고
    • cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
    • Jhala U.S., Canettieri G., Screaton R.A., et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Gene Dev 17 (2003) 1575-1580
    • (2003) Gene Dev , vol.17 , pp. 1575-1580
    • Jhala, U.S.1    Canettieri, G.2    Screaton, R.A.3
  • 38
    • 52449129375 scopus 로고    scopus 로고
    • Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels
    • Li L., Yang G., Li Q., et al. Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels. Diabetes Obes Metab 10 (2008) 921-930
    • (2008) Diabetes Obes Metab , vol.10 , pp. 921-930
    • Li, L.1    Yang, G.2    Li, Q.3
  • 39
    • 0042822138 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes
    • Valverde A.M., Burks D.J., Fabregat I., et al. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 52 (2003) 2239-2248
    • (2003) Diabetes , vol.52 , pp. 2239-2248
    • Valverde, A.M.1    Burks, D.J.2    Fabregat, I.3
  • 40
    • 31044446941 scopus 로고    scopus 로고
    • Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
    • Dong X., Park S., Lin X., Copps K., Yi X., and White M.F. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116 (2006) 101-114
    • (2006) J Clin Invest , vol.116 , pp. 101-114
    • Dong, X.1    Park, S.2    Lin, X.3    Copps, K.4    Yi, X.5    White, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.