Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus

Metabolism: Clinical and Experimental

Volumn 53, Issue 7, 2004, Pages 836-841

  Heled, Yuval ^b   Shapiro, Yair ^b   Shani, Yoav ^b   Moran, Daniel S ^b   Langzam, Lea ^b   Barash, Varda ^b   Sampson, Sanford R ^b   Meyerovitch, Joseph ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME INHIBITION; EXERCISE; INSULIN SENSITIVITY; LIVER FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PSAMMOMYS OBESUS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; EATING; ENERGY METABOLISM; GERBILLINAE; GLUCOSE-6-PHOSPHATASE; INSULIN; LIVER; MALE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHYSICAL CONDITIONING, ANIMAL; PRECIPITIN TESTS; PROTEINS; SIGNAL TRANSDUCTION;

EID: 3042526122     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.02.001     Document Type: Article

References (35)

1. Kriska A.M., LaPorte R.E., Pettit D.J., et al. The association of physical activity with obesity, fat distribution and glucose intolerance in Pima indians. Diabetologia. 36:1993;863-869
2. Pan X.R., Li G.W., Hu Y.H., et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. Diabetes Care. 20:1997;537-544
3. Arciero P.J., Vukovich M.D., Holloszy J.O., et al. Comparison of short term diet and exercise on insulin action in individuals with abnormal glucose tolerance. J Appl Physiol. 86:1999;1930-1935
4. Kelley D.E., Goodpaster B.H. Effects of exercise on glucose homeostasis in type 2 diabetes mellitus. Med Sci Sports Exerc. 33:2001;S495-S501
5. McMurray R.G., Bauman M.J., Harrell J.S., et al. Effects of improvement in aerobic power on resting insulin and glucose concentration in children. Eur J Appl Physiol. 81:2000;132-139
6. Haddad F., Adams G.R. Exercise effects on muscle insulin signaling and action selected contribution Acute cellular and molecular responses to resistance exercise. J Appl Physiol. 93:2002;394-403
7. Sakamoto K., Goodyear L.J. Exercise effects on muscle insulin signaling and action. Invited review Intracellular signaling in contracting skeletal muscle. J Appl Physiol. 93:2002;369-383
8. Nara M., Kanda T., Tsukui S., et al. Running exercise increases tumor necrosis factor α secreting from mesenteric fat in insulin resistant rats. Life Sci. 65:1999;237-244
9. Ishizuka T., Miura A., Kajita K., et al. Alteration in insulin induced postreceptor signaling in adipocyte of the Otsuka Long-Evans Tokushima fatty rat strain. J Endocrinol. 156:1998;1-13
10. Gauthier M.S., Couturier K., Latour J.G., et al. Concurrent exercise prevents high fat diet induced macrovesicular hepatic steatosis. J Appl Physiol. 94:2003;2127-2134
11. Podolin D.A., Wei Y., Pagliassotti M.J. Effects of high fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats. J Appl Physiol. 86:1999;1374-1380
12. Mosseri R., Waner T., Shefi M., et al. Gluconeogenesis in non obese diabetics (NOD) mice In vivo effects of vanadate treatment on hepatic glucose 6 phosphatase and phosphoenolpyruvate carboxykinase. Metabolism. 49:2000;321-325
13. Rutter G.A. Diabetes The importance of the liver. Curr Biol. 10:2000;R736-R738
14. Clore J.N., Stillman J., Sugerman H. Glucose 6 phosphatase flux in vitro is increased in type 2 diabetes. Diabetes. 49:2000;969-974
15. Michael M.D., Kulkarni R.N., Postic C., et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 6:2000;87-97
16. Pagliassotti M.J., Kang J., Thresher J.S., et al. Elevated basal PI-3 kinase activity and reduced insulin signaling in sucrose induced hepatic insulin resistance. Am J Physiol. 282:2002;E170-E176
17. Boden G., Chen X., Stein T.P. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am J Physiol. 280:2001;E23-E30
18. Shafrir E. Nonrecognition of insulin as gluconeogenesis suppressant - Manifestation of selective hepatic insulin resistance in several animal species with type 2 diabetes Sand rats, spiny mice and db/db mice. Shafrir E., Renold A.E. Lessons From Animal Diabetes. 1988;304-315 Libbey, London, UK
19. Chang H.C., Lane M.D. The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. J Biol Chem. 241:1996;2413-2420
20. Heled Y., Shapiro Y., Shani Y., et al. Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus. Am J Physiol. 282:2002;E370-E375
21. Heled Y., Shapiro Y., Shani Y. Physical exercise enhances PKC δ activity and insulin receptor tyrosine phosphorylation in diabetes prone Psammomys obesus. Metabolism. 52:2003;1028-1033
22. Kalman R., Adler J.A., Lazarovici G., et al. The efficiency of sand rat metabolism is responsible for development of obesity and diabetes. J Basic Clin Physiol Pharmacol. 4:1993;57-68
23. Kalman R., Ziv E., Shafrir E., et al. Psammomys obesus and the albino rat - Two different models of nutritional insulin resistance, representing two different types of human populations. Lab Anim. 35:2001;346-352
24. Shafrir E., Ziv E. Cellular mechanism of nutritionally induced insulin resistance The desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. J Basic Clin Physiol Pharmacol. 9:1998;347-385
25. Ziv E., Kalman R., Hershkop K., et al. Insulin resistance in the NIDDM model Psammomys obesus in the normoglycaemic, normoinsulinemic state. Diabetologia. 39:1996;1269-1275
26. Ikeda Y., Olsen G.S., Ziv E., et al. Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus. Diabetes. 50:2001;584-592
27. Hanson R.W., Reshef L. Regulation of phosphenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem. 66:1997;581-611
28. Gross D.J., Leibowoitz G., Cerasi E., et al. Increased susceptibility of islets from diabetes prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology. 137:1996;5610-5615
29. Burchell A., Humae R., Burchell B. A new microtechnique for the analysis of the human hepatic glucose 6 phosphatase system. Clin Chim Acta. 173:1988;183-192
30. Kahn B.B. Type 2 diabetes - When insulin secretion fails to compensate for insulin resistance. Cell. 92:1998;593-596
31. Defronzo R.A., Sherwin R.S., Kraemer N. Effect of physical training on insulin action in obesity. Diabetes. 36:1987;1379-1385
32. Cusi K., Cukier S., Defronzo R.A., et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab. 86:2001;1410-1417
33. Argaud D., Zhang Q., Pan W., et al. Regulation of rat liver glucose 6 phosphatase gene expression in different nutritional and hormonal states Gene structure and 5′ flanking sequence. Diabetes. 45:1996;1563-1571
34. Rother K.I., Imai Y., Caruso M., et al. Evidence that IRS 2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem. 273:1998;17491-17497
35. Higaki Y., Wojtaszweski J.F., Hirshman M.F., et al. Insulin receptor substrate 2 is not necessary for insulin and exercise stimulated glucose transport in skeletal muscle. J Biol Chem. 274:1999;20791-20795