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Volumn 19, Issue 5, 2009, Pages 454-460

Stage- and area-specific control of stem cells in the developing nervous system

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CORTEX; BRAIN DEVELOPMENT; CELL CLONING; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; CELL RENEWAL; CELL SUBPOPULATION; CELL SURVIVAL; CELL TYPE; CENTRAL NERVOUS SYSTEM; DEVELOPMENTAL STAGE; DOPAMINERGIC NERVE CELL; EMBRYO PATTERN FORMATION; EMBRYONIC STEM CELL; GENETIC REGULATION; GROWTH REGULATION; HUMAN; IN VITRO STUDY; MESENCEPHALON; MESENCHYME CELL; MITOSIS; MULTIPOTENT STEM CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL CREST; NEURAL STEM CELL; NEURAL TUBE; NEUROEPITHELIUM; NEURULATION; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION;

EID: 71849114542     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2009.08.002     Document Type: Review
Times cited : (19)

References (54)
  • 1
    • 0141561866 scopus 로고    scopus 로고
    • Multipotentiality of the neural crest
    • Le Douarin N.M., and Dupin E. Multipotentiality of the neural crest. Curr Opin Genet Dev 13 (2003) 529-536
    • (2003) Curr Opin Genet Dev , vol.13 , pp. 529-536
    • Le Douarin, N.M.1    Dupin, E.2
  • 2
    • 36849036401 scopus 로고    scopus 로고
    • Morphogens and the control of cell proliferation and patterning in the spinal cord
    • Ulloa F., and Briscoe J. Morphogens and the control of cell proliferation and patterning in the spinal cord. Cell Cycle 6 (2007) 2640-2649
    • (2007) Cell Cycle , vol.6 , pp. 2640-2649
    • Ulloa, F.1    Briscoe, J.2
  • 3
    • 0035924596 scopus 로고    scopus 로고
    • Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
    • Liu J.P., Laufer E., and Jessell T.M. Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids. Neuron 32 (2001) 997-1012
    • (2001) Neuron , vol.32 , pp. 997-1012
    • Liu, J.P.1    Laufer, E.2    Jessell, T.M.3
  • 4
    • 46549088641 scopus 로고    scopus 로고
    • Transcriptional mechanisms controlling motor neuron diversity and connectivity
    • Dalla Torre di Sanguinetto S.A., Dasen J.S., and Arber S. Transcriptional mechanisms controlling motor neuron diversity and connectivity. Curr Opin Neurobiol 18 (2008) 36-43
    • (2008) Curr Opin Neurobiol , vol.18 , pp. 36-43
    • Dalla Torre di Sanguinetto, S.A.1    Dasen, J.S.2    Arber, S.3
  • 5
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud E., McMahon A.P., and Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135 (2008) 2489-2503
    • (2008) Development , vol.135 , pp. 2489-2503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 6
    • 33750316973 scopus 로고    scopus 로고
    • Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects
    • Bertrand N., and Dahmane N. Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects. Trends Cell Biol 16 (2006) 597-605
    • (2006) Trends Cell Biol , vol.16 , pp. 597-605
    • Bertrand, N.1    Dahmane, N.2
  • 7
    • 11144324462 scopus 로고    scopus 로고
    • Roof plate-dependent patterning of the vertebrate dorsal central nervous system
    • Chizhikov V.V., and Millen K.J. Roof plate-dependent patterning of the vertebrate dorsal central nervous system. Dev Biol 277 (2005) 287-295
    • (2005) Dev Biol , vol.277 , pp. 287-295
    • Chizhikov, V.V.1    Millen, K.J.2
  • 8
    • 0034677471 scopus 로고    scopus 로고
    • Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    • Lee K.J., Dietrich P., and Jessell T.M. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403 (2000) 734-740
    • (2000) Nature , vol.403 , pp. 734-740
    • Lee, K.J.1    Dietrich, P.2    Jessell, T.M.3
  • 9
    • 0032957137 scopus 로고    scopus 로고
    • The specification of dorsal cell fates in the vertebrate central nervous system
    • Lee K.J., and Jessell T.M. The specification of dorsal cell fates in the vertebrate central nervous system. Annu Rev Neurosci 22 (1999) 261-294
    • (1999) Annu Rev Neurosci , vol.22 , pp. 261-294
    • Lee, K.J.1    Jessell, T.M.2
  • 10
    • 0035038390 scopus 로고    scopus 로고
    • Stem cells and pattern formation in the nervous system. The possible versus the actual
    • Anderson D.J. Stem cells and pattern formation in the nervous system. The possible versus the actual. Neuron 30 (2001) 19-35
    • (2001) Neuron , vol.30 , pp. 19-35
    • Anderson, D.J.1
  • 11
    • 1642445643 scopus 로고    scopus 로고
    • Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    • Tropepe V., Sibilia M., Ciruna B.G., Rossant J., Wagner E.F., and van der Kooy D. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol 208 (1999) 166-188
    • (1999) Dev Biol , vol.208 , pp. 166-188
    • Tropepe, V.1    Sibilia, M.2    Ciruna, B.G.3    Rossant, J.4    Wagner, E.F.5    van der Kooy, D.6
  • 12
    • 0034981770 scopus 로고    scopus 로고
    • Identification of two distinct types of multipotent neural precursors that appear sequentially during CNS development
    • Ciccolini F. Identification of two distinct types of multipotent neural precursors that appear sequentially during CNS development. Mol Cell Neurosci 17 (2001) 895-907
    • (2001) Mol Cell Neurosci , vol.17 , pp. 895-907
    • Ciccolini, F.1
  • 13
    • 0033638139 scopus 로고    scopus 로고
    • BMP and FGF regulate the development of EGF-responsive neural progenitor cells
    • Lillien L., and Raphael H. BMP and FGF regulate the development of EGF-responsive neural progenitor cells. Development 127 (2000) 4993-5005
    • (2000) Development , vol.127 , pp. 4993-5005
    • Lillien, L.1    Raphael, H.2
  • 14
    • 68349105811 scopus 로고    scopus 로고
    • Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors
    • The timely transition from neuroepithelial cells to radial glia cells depends on the morphogen Fgf10. Deletion of Fgf10 leads to delayed radial glial differentiation selectively in the rostral cortex. The result is an increase in symmetric cell division, yielding more neuroepithelial cells and initally less neurons. The bigger pool of neuroepithelial cells eventually leads to an excess in neurons and basal progenitors resulting in an increased laminar thickness.
    • Sahara S., and O'Leary D.D. Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron 63 (2009) 48-62. The timely transition from neuroepithelial cells to radial glia cells depends on the morphogen Fgf10. Deletion of Fgf10 leads to delayed radial glial differentiation selectively in the rostral cortex. The result is an increase in symmetric cell division, yielding more neuroepithelial cells and initally less neurons. The bigger pool of neuroepithelial cells eventually leads to an excess in neurons and basal progenitors resulting in an increased laminar thickness.
    • (2009) Neuron , vol.63 , pp. 48-62
    • Sahara, S.1    O'Leary, D.D.2
  • 16
    • 34247532433 scopus 로고    scopus 로고
    • Timing is everything: making neurons versus glia in the developing cortex
    • Miller F.D., and Gauthier A.S. Timing is everything: making neurons versus glia in the developing cortex. Neuron 54 (2007) 357-369
    • (2007) Neuron , vol.54 , pp. 357-369
    • Miller, F.D.1    Gauthier, A.S.2
  • 17
    • 50249103813 scopus 로고    scopus 로고
    • Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development
    • Coup-tfI and II are essential molecular switches in the temporal specification of ESC-derived NSCs, including the acquisition of gliogenic competence with time. Injecting shRNA-encoding lentivirus into the ventricles of E10.5 embryos in utero, complemented by in vitro studies, identified Coup-tfI/II as crucial players in the timing mechanism that intrinsically determines NSC competence.
    • Naka H., Nakamura S., Shimazaki T., and Okano H. Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development. Nat Neurosci 11 (2008) 1014-1023. Coup-tfI and II are essential molecular switches in the temporal specification of ESC-derived NSCs, including the acquisition of gliogenic competence with time. Injecting shRNA-encoding lentivirus into the ventricles of E10.5 embryos in utero, complemented by in vitro studies, identified Coup-tfI/II as crucial players in the timing mechanism that intrinsically determines NSC competence.
    • (2008) Nat Neurosci , vol.11 , pp. 1014-1023
    • Naka, H.1    Nakamura, S.2    Shimazaki, T.3    Okano, H.4
  • 19
    • 1142298447 scopus 로고    scopus 로고
    • Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    • Lee H.Y., Kleber M., Hari L., Brault V., Suter U., Taketo M.M., Kemler R., and Sommer L. Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 303 (2004) 1020-1023
    • (2004) Science , vol.303 , pp. 1020-1023
    • Lee, H.Y.1    Kleber, M.2    Hari, L.3    Brault, V.4    Suter, U.5    Taketo, M.M.6    Kemler, R.7    Sommer, L.8
  • 21
    • 0029897371 scopus 로고    scopus 로고
    • Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members
    • Shah N.M., Groves A.K., and Anderson D.J. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 (1996) 331-343
    • (1996) Cell , vol.85 , pp. 331-343
    • Shah, N.M.1    Groves, A.K.2    Anderson, D.J.3
  • 23
    • 35348917234 scopus 로고    scopus 로고
    • Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects
    • Jia Q., McDill B.W., Li S.Z., Deng C., Chang C.P., and Chen F. Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol 311 (2007) 172-184
    • (2007) Dev Biol , vol.311 , pp. 172-184
    • Jia, Q.1    McDill, B.W.2    Li, S.Z.3    Deng, C.4    Chang, C.P.5    Chen, F.6
  • 24
    • 36549042570 scopus 로고    scopus 로고
    • Smad4 is required to regulate the fate of cranial neural crest cells
    • Ko S.O., Chung I.H., Xu X., Oka S., Zhao H., Cho E.S., Deng C., and Chai Y. Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol 312 (2007) 435-447
    • (2007) Dev Biol , vol.312 , pp. 435-447
    • Ko, S.O.1    Chung, I.H.2    Xu, X.3    Oka, S.4    Zhao, H.5    Cho, E.S.6    Deng, C.7    Chai, Y.8
  • 25
    • 0033525587 scopus 로고    scopus 로고
    • Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
    • Morrison S.J., White P.M., Zock C., and Anderson D.J. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 96 (1999) 737-749
    • (1999) Cell , vol.96 , pp. 737-749
    • Morrison, S.J.1    White, P.M.2    Zock, C.3    Anderson, D.J.4
  • 28
    • 0037104668 scopus 로고    scopus 로고
    • Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness
    • Kruger G.M., Mosher J.T., Bixby S., Joseph N., Iwashita T., and Morrison S.J. Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 35 (2002) 657-669
    • (2002) Neuron , vol.35 , pp. 657-669
    • Kruger, G.M.1    Mosher, J.T.2    Bixby, S.3    Joseph, N.4    Iwashita, T.5    Morrison, S.J.6
  • 29
    • 41449116604 scopus 로고    scopus 로고
    • Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    • Isolation and characterization of NCSC-like cells from various adult tissues revealed differences in self-renewal as well as differentiation potential according to the tissue source. This study also provides a potential explanation for the origin of neural cells formed from bone marrow in culture.
    • Nagoshi N., Shibata S., Kubota Y., Nakamura M., Nagai Y., Satoh E., Morikawa S., Okada Y., Mabuchi Y., Katoh H., et al. Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell 2 (2008) 392-403. Isolation and characterization of NCSC-like cells from various adult tissues revealed differences in self-renewal as well as differentiation potential according to the tissue source. This study also provides a potential explanation for the origin of neural cells formed from bone marrow in culture.
    • (2008) Cell Stem Cell , vol.2 , pp. 392-403
    • Nagoshi, N.1    Shibata, S.2    Kubota, Y.3    Nakamura, M.4    Nagai, Y.5    Satoh, E.6    Morikawa, S.7    Okada, Y.8    Mabuchi, Y.9    Katoh, H.10
  • 30
    • 60849123910 scopus 로고    scopus 로고
    • Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1
    • A combination of in vivo and elaborate in vitro assays demonstrated that the small Rho GTPases Cdc42 and Rac1 are essential for the proliferation control specifically of late EGF-responsive, but not of early FGF-responsive NCSCs. In Cdc42 and Rac1 mutant animals most if not all NC target tissues are reduced in size because of an increase in cell cycle exit. Thus, these small Rho GTPases appear to control growth of virtually the entire pool of postmigratory NCSCs at fetal stages.
    • Fuchs S., Herzog D., Sumara G., Buchmann-Moller S., Civenni G., Wu X., Chrostek-Grashoff A., Suter U., Ricci R., Relvas J.B., et al. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell 4 (2009) 236-247. A combination of in vivo and elaborate in vitro assays demonstrated that the small Rho GTPases Cdc42 and Rac1 are essential for the proliferation control specifically of late EGF-responsive, but not of early FGF-responsive NCSCs. In Cdc42 and Rac1 mutant animals most if not all NC target tissues are reduced in size because of an increase in cell cycle exit. Thus, these small Rho GTPases appear to control growth of virtually the entire pool of postmigratory NCSCs at fetal stages.
    • (2009) Cell Stem Cell , vol.4 , pp. 236-247
    • Fuchs, S.1    Herzog, D.2    Sumara, G.3    Buchmann-Moller, S.4    Civenni, G.5    Wu, X.6    Chrostek-Grashoff, A.7    Suter, U.8    Ricci, R.9    Relvas, J.B.10
  • 31
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5    Morrison, S.J.6
  • 32
    • 61849144426 scopus 로고    scopus 로고
    • Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    • Overexpression of Bmi-1 in cell culture and by electroporation in vivo increases self-renewal of NSCs mainly by repressing the cell cycle inhibitor p21. However, the effect on self-renewal is much more striking in forebrain than in spinal cord-derived NSCs. This regional difference in the interpretation of Bmi-1 is because of the presence of FoxG1, which is specifically expressed in the forebrain and is essential for in the increase in self-renewal upon Bmi-1 overexpression.
    • Fasano C.A., Phoenix T.N., Kokovay E., Lowry N., Elkabetz Y., Dimos J.T., Lemischka I.R., Studer L., and Temple S. Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev 23 (2009) 561-574. Overexpression of Bmi-1 in cell culture and by electroporation in vivo increases self-renewal of NSCs mainly by repressing the cell cycle inhibitor p21. However, the effect on self-renewal is much more striking in forebrain than in spinal cord-derived NSCs. This regional difference in the interpretation of Bmi-1 is because of the presence of FoxG1, which is specifically expressed in the forebrain and is essential for in the increase in self-renewal upon Bmi-1 overexpression.
    • (2009) Genes Dev , vol.23 , pp. 561-574
    • Fasano, C.A.1    Phoenix, T.N.2    Kokovay, E.3    Lowry, N.4    Elkabetz, Y.5    Dimos, J.T.6    Lemischka, I.R.7    Studer, L.8    Temple, S.9
  • 33
    • 63549087793 scopus 로고    scopus 로고
    • Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo
    • He S., Iwashita T., Buchstaller J., Molofsky A.V., Thomas D., and Morrison S.J. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol 328 (2009) 257-272
    • (2009) Dev Biol , vol.328 , pp. 257-272
    • He, S.1    Iwashita, T.2    Buchstaller, J.3    Molofsky, A.V.4    Thomas, D.5    Morrison, S.J.6
  • 34
    • 7744241519 scopus 로고    scopus 로고
    • Wnt signaling and the regulation of stem cell function
    • Kleber M., and Sommer L. Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol 16 (2004) 681-687
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 681-687
    • Kleber, M.1    Sommer, L.2
  • 35
    • 0037135177 scopus 로고    scopus 로고
    • Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    • Chenn A., and Walsh C.A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297 (2002) 365-369
    • (2002) Science , vol.297 , pp. 365-369
    • Chenn, A.1    Walsh, C.A.2
  • 36
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason S.G., and McMahon A.P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129 (2002) 2087-2098
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 37
  • 38
    • 33947098898 scopus 로고    scopus 로고
    • Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord
    • Ille F., Atanasoski S., Falk S., Ittner L.M., Marki D., Buchmann-Moller S., Wurdak H., Suter U., Taketo M.M., and Sommer L. Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Dev Biol 304 (2007) 394-408
    • (2007) Dev Biol , vol.304 , pp. 394-408
    • Ille, F.1    Atanasoski, S.2    Falk, S.3    Ittner, L.M.4    Marki, D.5    Buchmann-Moller, S.6    Wurdak, H.7    Suter, U.8    Taketo, M.M.9    Sommer, L.10
  • 39
    • 42649120343 scopus 로고    scopus 로고
    • Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    • TGFβ signaling specifically regulates self-renewal of NSCs in the dorsal midbrain, but not of the ventral midbrain or the dorsal forebrain. Deletion of Tgfbr2, an essential receptor for the transduction of the TGFβ signal, leads to induction of canonical Wnt signaling and the specific expansion of the dorsal midbrain neuroepithelium. The area-specific interpretation of TGFβ depends on extrinsic as well as on intrinsic differences of NCSs in the forebrain and the midbrain.
    • Falk S., Wurdak H., Ittner L.M., Ille F., Sumara G., Schmid M.T., Draganova K., Lang K.S., Paratore C., Leveen P., et al. Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell 2 (2008) 472-483. TGFβ signaling specifically regulates self-renewal of NSCs in the dorsal midbrain, but not of the ventral midbrain or the dorsal forebrain. Deletion of Tgfbr2, an essential receptor for the transduction of the TGFβ signal, leads to induction of canonical Wnt signaling and the specific expansion of the dorsal midbrain neuroepithelium. The area-specific interpretation of TGFβ depends on extrinsic as well as on intrinsic differences of NCSs in the forebrain and the midbrain.
    • (2008) Cell Stem Cell , vol.2 , pp. 472-483
    • Falk, S.1    Wurdak, H.2    Ittner, L.M.3    Ille, F.4    Sumara, G.5    Schmid, M.T.6    Draganova, K.7    Lang, K.S.8    Paratore, C.9    Leveen, P.10
  • 40
    • 18244382560 scopus 로고    scopus 로고
    • Neural stem cells and neurospheres - re-evaluating the relationship
    • Reynolds B.A., and Rietze R.L. Neural stem cells and neurospheres - re-evaluating the relationship. Nat Methods 2 (2005) 333-336
    • (2005) Nat Methods , vol.2 , pp. 333-336
    • Reynolds, B.A.1    Rietze, R.L.2
  • 41
    • 0033849349 scopus 로고    scopus 로고
    • BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners
    • Dou C., Lee J., Liu B., Liu F., Massague J., Xuan S., and Lai E. BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. Mol Cell Biol 20 (2000) 6201-6211
    • (2000) Mol Cell Biol , vol.20 , pp. 6201-6211
    • Dou, C.1    Lee, J.2    Liu, B.3    Liu, F.4    Massague, J.5    Xuan, S.6    Lai, E.7
  • 42
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J., Le H.V., Shen L., Anderson S.A., and Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117 (2004) 211-223
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 43
    • 1642377931 scopus 로고    scopus 로고
    • The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells
    • Israsena N., Hu M., Fu W., Kan L., and Kessler J.A. The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. Dev Biol 268 (2004) 220-231
    • (2004) Dev Biol , vol.268 , pp. 220-231
    • Israsena, N.1    Hu, M.2    Fu, W.3    Kan, L.4    Kessler, J.A.5
  • 45
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • Ying Q.L., Stavridis M., Griffiths D., Li M., and Smith A. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 21 (2003) 183-186
    • (2003) Nat Biotechnol , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 49
    • 52149102948 scopus 로고    scopus 로고
    • An intrinsic mechanism of corticogenesis from embryonic stem cells
    • Starting from ESCs it is possible to completely recapitulate the spatiotemporal specification of NSCs in the cerebral cortex in vitro, resulting in the sequential generation of neurons found in the different layers of the cortex. In addition, this paper demonstrates that it is possible to specify neurons in vitro with a particular cortical area-identity, namely of the occipital/visual cortex. Thus, the intrinsic program of corticogenesis can be engaged even in cells that were never located in a brain.
    • Gaspard N., Bouschet T., Hourez R., Dimidschstein J., Naeije G., van den Ameele J., Espuny-Camacho I., Herpoel A., Passante L., Schiffmann S.N., et al. An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature 455 (2008) 351-357. Starting from ESCs it is possible to completely recapitulate the spatiotemporal specification of NSCs in the cerebral cortex in vitro, resulting in the sequential generation of neurons found in the different layers of the cortex. In addition, this paper demonstrates that it is possible to specify neurons in vitro with a particular cortical area-identity, namely of the occipital/visual cortex. Thus, the intrinsic program of corticogenesis can be engaged even in cells that were never located in a brain.
    • (2008) Nature , vol.455 , pp. 351-357
    • Gaspard, N.1    Bouschet, T.2    Hourez, R.3    Dimidschstein, J.4    Naeije, G.5    van den Ameele, J.6    Espuny-Camacho, I.7    Herpoel, A.8    Passante, L.9    Schiffmann, S.N.10
  • 50
    • 58049206540 scopus 로고    scopus 로고
    • Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells
    • Okada Y., Matsumoto A., Shimazaki T., Enoki R., Koizumi A., Ishii S., Itoyama Y., Sobue G., and Okano H. Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells 26 (2008) 3086-3098
    • (2008) Stem Cells , vol.26 , pp. 3086-3098
    • Okada, Y.1    Matsumoto, A.2    Shimazaki, T.3    Enoki, R.4    Koizumi, A.5    Ishii, S.6    Itoyama, Y.7    Sobue, G.8    Okano, H.9
  • 51
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • Ingham P.W., and McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15 (2001) 3059-3087
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 52
    • 34648816863 scopus 로고    scopus 로고
    • Retinoic acid in the development, regeneration and maintenance of the nervous system
    • Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci 8 (2007) 755-765
    • (2007) Nat Rev Neurosci , vol.8 , pp. 755-765
    • Maden, M.1
  • 53
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse R. Wnt signaling and stem cell control. Cell Res 18 (2008) 523-527
    • (2008) Cell Res , vol.18 , pp. 523-527
    • Nusse, R.1
  • 54
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2


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