A therapeutic time window for anti-CD11d monoclonal antibody treatment yielding reduced secondary tissue damage and enhanced behavioral recovery following severe spinal cord injury

Journal of Neurosurgery: Spine

Volumn 5, Issue 4, 2006, Pages 343-352

  Ditor, David S ^a,b   Bao, Feng ^a   Chen, Yuhua ^a   Dekaban, Gregory A ^a   Weaver, Lynne C ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b BROCK UNIVERSITY   (Canada)

Author keywords

Inflammation; Neuroprotection; Rat; Reactive oxygen species; Spinal cord injury

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD11D; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CD11 ANTIGEN; CD11D PROTEIN, RAT; IMMUNOLOGIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC DYSREFLEXIA; BRAIN FUNCTION; CELL DAMAGE; COLON DILATATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; LIPID PEROXIDATION; MACROPHAGE; MEAN ARTERIAL PRESSURE; NERVE ROOT COMPRESSION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; RAT; SCORING SYSTEM; SPINAL CORD INJURY; TISSUE INJURY; ANIMAL; DRUG ADMINISTRATION; FEMALE; IMMUNOLOGY; MOTOR ACTIVITY; OXIDATIVE STRESS; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; VERTEBRA; WISTAR RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11; AUTONOMIC DYSREFLEXIA; DRUG ADMINISTRATION SCHEDULE; FEMALE; IMMUNOLOGIC FACTORS; MOTOR ACTIVITY; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SPINAL CORD INJURIES; THORACIC VERTEBRAE;

EID: 33750696659     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2006.5.4.343     Document Type: Article

References (44)

1. Anderson KD: Targeting recovery: priorities of the spinal cordinjured population. J Neurotrauma 21:1371-1383, 2004
2. Babior BM: NADPH oxidase: an update. Blood 93:1464-1476, 1999
3. Bao F, Chen Y, Dekaban GA, Weaver LC: An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in rats. J Neurochem 90:1194-1204, 2004
4. Bao F, Chen Y, Dekaban GA, Weaver LC: Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. J Neurochem 88:1335-1344, 2004
5. Bao F, Dekaban GA, Weaver LC: Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats. J Neurochem 94:1361-1373, 2005
6. Barone FC, Hillegass LM, Price WJ, White RF, Lee EV, Feuerstein GZ, et al: Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification. J Neurosci Res 29:336-345, 1991
7. Bartholdi D, Schwab ME: Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 672:177-186, 1995
8. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
9. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87:1620-1624, 1990
10. Bethea JR, Dietrich WD: Targeting the host inflammatory response in traumatic spinal cord injury. Curr Opin Neurol 15: 355-360, 2002
11. Bevilacqua MP: Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 11:767-804, 1993
12. Biagas KV, Uhl MW, Schiding JK, Nemoto EM, Kochanek PM: Assessment of posttraumatic polymorphonuclear leukocyte accumulation in rat brain using tissue myeloperoxidase assay and vinblastine treatment. J Neurotrauma 9:363-371, 1992
13. Blackburn AC, Doe WF, Buffinton GD: Protein carbonyl formation on mucosal proteins in vitro and in dextran sulfateinduced colitis. Free Radic Biol Med 27:262-270, 1999
14. Bradley PP, Priebat DA, Christensen RD, Rothstein G: Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78: 206-209, 1982
15. DeLeo FR, Quinn MT: Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol 60:677-691, 1996
16. Griendling KK, Sorescu D, Ushio-Fukai M: NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000
17. Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, et al: Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic and motor function. J Neurosci 24: 4043-4051, 2004
18. Guth L, Zhang Z, Di Prospero NA, Joubin K, Fitch MT: Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function. Exp Neurol 126:76-87, 1994
19. Hurlbert RJ: Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg (1 Suppl) 93:1-7, 2000
20. Hurlbert RJ: The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine 26 (24 Suppl):S39-S46, 2001
21. Juurlink BH, Paterson PG: Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies. J Spinal Cord Med 21:309-334, 1998
22. Keller JN, Mark RJ, Bruce AJ, Blanc E, Rothstein JD, Uchida K, et al: 4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. J Neurosci Res 80:685-696, 1997
23. Levine RL: Oxidative modification of glutamine synthetase. I: Inactivation is due to loss of one histidine residue. J Biol Chem 258:11823-11827, 1983
24. Lewen A, Matz P, Chan PH: Free radical pathways in CNS injury. J Neurotrauma 17:871-890, 2000
25. Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH: Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis 8:380-390, 2001
26. Mabon PJ, Weaver LC, Dekaban GA: Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin aD: a potential new anti-inflammatory treatment. Exp Neurol 166:52-64, 2000
27. Maiorov DN, Krenz NR, Krassioukov AV, Weaver LC: Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am J Physiol 273:H1266-H1274, 1997
28. Marsh DR, Weaver LC: Autonomic dysreflexia, induced by noxious or innocuous stimulation, does not depend on changes in dorsal horn substance P. J Neurotrauma 21:817-828, 2004
29. Nakamura J, La DK, Swenberg JA: 5′-nicked apurinic/apyrimidinic sites are resistant to β-elimination by β-polymerase and are persistent in human cultured cells after oxidative stress. J Biol Chem 275:5323-5328, 2000
30. Nakauchi K, Ikata T, Katoh S, Hamada Y, Tsuchiya K, Fukuzawa K: Effects of lecithinized superoxide dismutase on rat spinal cord injury. J Neurotrauma 13:573-582, 1996
31. Neish AS, Read MA, Thanos D, Pine R, Maniatis T, Collins T: Endothelial interferon regulatory factor 1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule 1. Mol Cell Biol 15:2558-2569, 1995
32. Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC: Anti-CD11d integrin antibody treatment restores normal serotinergic projections to the dorsal, intermediate and ventral horns of the injured spinal cord. J Neurosci 25:637-647, 2005
33. O'Banion MK: Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 13:45-82, 1999
34. Pereira WE, Hoyano Y, Summons RE, Bacon VA, Duffield AM: Chlorination studies. II. The reaction of aqueous hypochlorous acid with α-amino acids and dipeptides. Biochim Biophys Acta 313:170-180, 1973
35. Popovich PG, Jones TB: Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol Sci 24:13-17, 2003
36. Rabchevsky AG, Fugaccia I, Sullivan PG, Blades DA, Scheff SW: Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci Res 68:7-18, 2002
37. Rapalino O, Lazarov-Spiegler O, Agranov E, Velan GJ, Yoles E, Fraidakis M, et al: Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med 4:814-821, 1998
38. Sapolsky RM: Stress, glucocorticoids, and damage to the nervous system: the current state of confusion. Stress 1:1-19, 1996
39. Saville LR, Simedria FC, Weaver LC, Dekaban GA: Treatment of spinal cord injury by using an antibody to the leukocyte integrin alpha D/beta 2 effectively prevents the early infiltration of phagocytes and monocytes/macrophages into the lesion. J Neurotrauma 19:1352-1359, 2002
40. Shanley TP, Warner RL, Crouch LD, Dietsch GN, Clark DL, O'Brien MM, et al: Requirements for ad in IgG immune complex-induced rat lung injury. J Immunol 160:1014-1020, 1998
41. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, et al: Role of neutrophils in spinal cord injury in the rat. Neuroscience 79:1177-1182, 1997
42. Uchida K, Stadtman ER: Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci U S A 89:4544-4548, 1992
43. Weaver LC, Verghese P, Bruce JC, Fehlings MG, Krenz NR, Marsh DR: Autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. J Neurotrauma 18:1107-1119, 2001
44. Xu JA, Hsu CY, Liu TH, Hogan EL, Perot PL Jr, Tai HH: Leukotriene B4 release and polymorphonuclear cell infiltration in spinal cord injury. J Neurochem 55:907-912, 1990