Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6893-6897

  Wang, Deyun ^a   Iera, Jaclyn ^a   Baker, Heather ^a   Hogan, Priscilla ^b   Ptak, Roger ^b   Yang, Lu ^c   Hartman, Tracy ^c   Buckheit Jr , Robert W ^c   Desjardins, Alexandre ^d   Yang, Ao ^d   Legault, Pascale ^d   Yedavalli, Venkat ^e   Jeang, Kuan Teh ^e   Appella, Daniel H ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c ImQuest Biosciences   (United States)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

HIV; Multivalency; RNA; TAR

Indexed keywords

OLIGOMER; SCAFFOLD PROTEIN; TAR DNA BINDING PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL ASSAY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA BINDING; RNA STRUCTURE; VIRUS REPLICATION;

ANTI-HIV AGENTS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; NUCLEIC ACID CONFORMATION; RNA, VIRAL; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 71849103193     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.078     Document Type: Article

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