The design, synthesis, and biological evaluation of novel substituted purines as HIV-1 Tat-TAR inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 265-272

  Yuan, Dekai ^a,c   He, Meizi ^a   Pang, Ruifang ^a   Lin, Shrong shi ^b   Li, Zhengming ^c   Yang, Ming ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

HIV Tat TAR inhibitors; Molecular modeling; Substituted purines

Indexed keywords

2 [2 DIETHYLAMINO 9 (3 DIETHYLAMINOPROPYL) 6 METHYL 9H PURIN 8 YLSULFANYL] N (2 GUANIDINOETHYL)ACETAMIDE; 2 [2 DIETHYLAMINO 9 (3 DIETHYLAMINOPROPYL) 6 METHYL 9H PURIN 8 YLSULFANYL] N (2 GUANIDINOPROPYL)ACETAMIDE; 2 [DIETHYLAMINO 9 (2 DIETHYLAMINOETHYL) 6 METHYL 9H PURIN 8 YLSULFANYL] N (2 GUANIDINOETHYL)ACETAMIDE; 2 [DIETHYLAMINO 9 (2 DIETHYLAMINOETHYL) 6 METHYL 9H PURIN 8 YLSULFANYL] N (2 GUANIDINOPROPYL)ACETAMIDE; ACETAMIDE DERIVATIVE; ANTIVIRUS AGENT; N (2 AMINOETHYL) 2 (2 DIETHYLAMINO 6 METHYL 9H PURIN 8 YLSULFANYL)ACETAMIDE; N (2 AMINOETHYL) 2 [2 DIETHYLAMINO 9 (2 DIETHYLAMINOETHYL) 6 METHYL 9H PURIN 8 YLSULFANYL]ACETAMIDE; N (2 GUANIDINOETHYL) 2 (2 DIETHYLAMINO 6 METHYL 9H PURIN 8 YLSULFANYL)ACETAMIDE HYDROSULFITE; N (3 AMINOETHYL) 2 [2 DIETHYLAMINO 9 (3 DIETHYLAMINOPROPYL) 6 METHYL 9H PURIN 8 YLSULFANYL]ACETAMIDE; N (3 AMINOPROPYL) 2 (2 DIETHYLAMINO 6 METHYL 9H PURIN 8 YLSULFANYL)ACETAMIDE; N (3 AMINOPROPYL) 2 [2 DIETHYLAMINO 9 (2 DIETHYLAMINOETHYL) 6 METHYL 9H PURIN 8 YLSULFANYL]ACETAMIDE; N (3 AMINOPROPYL) 2 [2 DIETHYLAMINO 9 (3 DIETHYLAMINOPROPYL) 6 METHYL 9H PURIN 8 YLSULFANYL]ACETAMIDE; N (3 GUANIDINOPROPYL) 2 (2 DIETHYLAMINO 6 METHYL 9H PURIN 8 YLSULFANYL)ACETAMIDE HYDROSULFITE; RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; SYNCYTIUM; TRANSACTIVATION;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; CELL PROLIFERATION; DRUG DESIGN; GENE PRODUCTS, TAT; GIANT CELLS; HIV LONG TERMINAL REPEAT; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; PURINES; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS);

HUMAN IMMUNODEFICIENCY VIRUS 1; RUMEX; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 33750947321     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.062     Document Type: Article

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