Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6845-6850

  Jadhav, Vinod D ^a   Duerfeldt, Adam S ^a   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Anti cancer; Geldanamycin; Hsp90; Radicicol

Indexed keywords

ESTER DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; RADICICOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; PROTEIN DEGRADATION;

ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; BENZOQUINONES; BICYCLO COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MACROLIDES; PROTEIN CONFORMATION;

EID: 71849087234     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.091     Document Type: Article

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