Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1588-1591

  Onodera, Hideyuki ^a   Kaneko, Masami ^a   Takahashi, Yuichi ^a   Uochi, Yumiko ^a   Funahashi, Jun ^a   Nakashima, Takayuki ^a   Soga, Shiro ^a   Suzuki, Makoto ^a   Ikeda, Shunichi ^a   Yamashita, Yoshinori ^a   Rahayu, Endang S ^b   Kanda, Yutaka ^a   Ichimura, Michio ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Ansamycin; Conformation; Geldanamycin; Hsp90; Inhibitor

Indexed keywords

BENZOQUINONE DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; PHENOL DERIVATIVE; ANTINEOPLASTIC AGENT; MACROCYCLIC LACTAM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG ISOLATION; DRUG STRUCTURE; STREPTOMYCES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; TUMOR CELL LINE;

STREPTOMYCES SP.;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STREPTOMYCES;

EID: 39849111639     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.072     Document Type: Article

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