메뉴 건너뛰기




Volumn 23, Issue 6, 2009, Pages 805-819

Is stomach spontaneously ageing? Pathophysiology of the ageing stomach

Author keywords

Atrophic gastritis; Dyspepsia; Ghrelin; Helicobacter pylori; Hypochlorhydria; Leptin; Ulcerogenesis

Indexed keywords

ANTACID AGENT; CHOLECYSTOKININ; CIMETIDINE; CYANOCOBALAMIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN; HISTAMINE H2 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; OMEPRAZOLE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTON PUMP INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VACUOLATING TOXIN;

EID: 71749117719     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2009.09.002     Document Type: Article
Times cited : (25)

References (96)
  • 1
    • 7044239406 scopus 로고    scopus 로고
    • Aging, the gastrointestinal tract, and risk of acid-related disease
    • Greenwald D.A. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med 117 (2004) 8S-13S
    • (2004) Am J Med , vol.117
    • Greenwald, D.A.1
  • 2
    • 9644283143 scopus 로고    scopus 로고
    • Changes in upper gastrointestinal physiology with age
    • Newton J.L. Changes in upper gastrointestinal physiology with age. Mech Ageing Dev 125 (2004) 867-870
    • (2004) Mech Ageing Dev , vol.125 , pp. 867-870
    • Newton, J.L.1
  • 3
    • 35349004160 scopus 로고    scopus 로고
    • Current management of Helicobacter pylori infections in the elderly
    • Salles N., and Megraud F. Current management of Helicobacter pylori infections in the elderly. Expert Rev Anti Infect Ther 5 (2007) 845-856
    • (2007) Expert Rev Anti Infect Ther , vol.5 , pp. 845-856
    • Salles, N.1    Megraud, F.2
  • 4
    • 0034920211 scopus 로고    scopus 로고
    • Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies
    • Pilotto A. Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. Drugs Aging 18 (2001) 487-494
    • (2001) Drugs Aging , vol.18 , pp. 487-494
    • Pilotto, A.1
  • 5
    • 34247534646 scopus 로고    scopus 로고
    • Basic mechanisms of the aging gastrointestinal tract
    • Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig Dis 25 (2007) 112-117
    • (2007) Dig Dis , vol.25 , pp. 112-117
    • Salles, N.1
  • 6
    • 0042574175 scopus 로고    scopus 로고
    • Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring
    • Shih G.L., Brensinger C., Katzka D.A., et al. Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring. Am J Gastroenterol 98 (2003) 1713-1718
    • (2003) Am J Gastroenterol , vol.98 , pp. 1713-1718
    • Shih, G.L.1    Brensinger, C.2    Katzka, D.A.3
  • 7
    • 0031749197 scopus 로고    scopus 로고
    • Effects of age on gastric alkaline and nonparietal fluid secretion in humans
    • Feldman M., and Cryer B. Effects of age on gastric alkaline and nonparietal fluid secretion in humans. Gerontology 44 (1998) 222-227
    • (1998) Gerontology , vol.44 , pp. 222-227
    • Feldman, M.1    Cryer, B.2
  • 8
    • 4143092458 scopus 로고    scopus 로고
    • Gastric acid secretion of normal Japanese subjects in relation to Helicobacter pylori infection, aging, and gender
    • Iijima K., Ohara S., Koike T., et al. Gastric acid secretion of normal Japanese subjects in relation to Helicobacter pylori infection, aging, and gender. Scand J Gastroenterol 39 (2004) 709-716
    • (2004) Scand J Gastroenterol , vol.39 , pp. 709-716
    • Iijima, K.1    Ohara, S.2    Koike, T.3
  • 9
    • 0035660980 scopus 로고    scopus 로고
    • Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study
    • Asaka M., Sugiyama T., Nobuta A., et al. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 6 (2001) 294-299
    • (2001) Helicobacter , vol.6 , pp. 294-299
    • Asaka, M.1    Sugiyama, T.2    Nobuta, A.3
  • 10
    • 0030775972 scopus 로고    scopus 로고
    • Helicobacter pylori, inflammation, mucosal damage, and apoptosis: pathogenesis and definition of gastric atrophy
    • Genta R.M. Helicobacter pylori, inflammation, mucosal damage, and apoptosis: pathogenesis and definition of gastric atrophy. Gastroenterology 113 (1997) S51-S55
    • (1997) Gastroenterology , vol.113
    • Genta, R.M.1
  • 11
    • 0036546142 scopus 로고    scopus 로고
    • Ten-year prospective follow-up study on the relationship between Helicobacter pylori infection and progression of atrophic gastritis, particularly assessed by endoscopic findings
    • Sakaki N., Kozawa H., Egawa N., et al. Ten-year prospective follow-up study on the relationship between Helicobacter pylori infection and progression of atrophic gastritis, particularly assessed by endoscopic findings. Aliment Pharmacol Ther 2 16 Suppl (2002) 198-203
    • (2002) Aliment Pharmacol Ther , vol.2 , Issue.16 SUPPL , pp. 198-203
    • Sakaki, N.1    Kozawa, H.2    Egawa, N.3
  • 12
    • 14544285951 scopus 로고    scopus 로고
    • Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer
    • Zhang C., Yamada N., Wu Y.L., et al. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer. World J Gastroenterol 11 (2005) 791-796
    • (2005) World J Gastroenterol , vol.11 , pp. 791-796
    • Zhang, C.1    Yamada, N.2    Wu, Y.L.3
  • 13
    • 0029075476 scopus 로고
    • Long-term sequelae of Helicobacter pylori gastritis
    • Kuipers E.J., Uyterlinde A.M., Pena A.S., et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet 345 (1995) 1525-1528
    • (1995) Lancet , vol.345 , pp. 1525-1528
    • Kuipers, E.J.1    Uyterlinde, A.M.2    Pena, A.S.3
  • 14
    • 0036188340 scopus 로고    scopus 로고
    • The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia
    • Kokkola A., Sipponen P., Rautelin H., et al. The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 16 (2002) 515-520
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 515-520
    • Kokkola, A.1    Sipponen, P.2    Rautelin, H.3
  • 15
    • 0036668705 scopus 로고    scopus 로고
    • Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis
    • Ito M., Haruma K., Kamada T., et al. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis. Aliment Pharmacol Ther 16 (2002) 1449-1456
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1449-1456
    • Ito, M.1    Haruma, K.2    Kamada, T.3
  • 16
    • 0035666790 scopus 로고    scopus 로고
    • Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection
    • Ruiz B., Garay J., Correa P., et al. Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection. Am J Gastroenterol 96 (2001) 3281-3287
    • (2001) Am J Gastroenterol , vol.96 , pp. 3281-3287
    • Ruiz, B.1    Garay, J.2    Correa, P.3
  • 17
    • 0036829450 scopus 로고    scopus 로고
    • Alteration of histological gastritis after cure of Helicobacter pylori infection
    • Hojo M., Miwa H., Ohkusa T., et al. Alteration of histological gastritis after cure of Helicobacter pylori infection. Aliment Pharmacol Ther 16 (2002) 1923-1932
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1923-1932
    • Hojo, M.1    Miwa, H.2    Ohkusa, T.3
  • 18
    • 33644811496 scopus 로고    scopus 로고
    • Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: prospective 4-year study
    • Di Mario F., Moussa A.M., Dal Bo N., et al. Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: prospective 4-year study. J Gastroenterol Hepatol 20 (2005) 1661-1666
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1661-1666
    • Di Mario, F.1    Moussa, A.M.2    Dal Bo, N.3
  • 19
    • 35948996629 scopus 로고    scopus 로고
    • The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis
    • Rokkas T., Pistiolas D., Sechopoulos P., et al. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter 2 12 Suppl (2007) 32-38
    • (2007) Helicobacter , vol.2 , Issue.12 SUPPL , pp. 32-38
    • Rokkas, T.1    Pistiolas, D.2    Sechopoulos, P.3
  • 20
    • 0036667550 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress
    • Naito Y., and Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 33 (2002) 323-336
    • (2002) Free Radic Biol Med , vol.33 , pp. 323-336
    • Naito, Y.1    Yoshikawa, T.2
  • 21
    • 0035866346 scopus 로고    scopus 로고
    • Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains
    • Moss S.F., Sordillo E.M., Abdalla A.M., et al. Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains. Cancer Res 61 (2001) 1406-1411
    • (2001) Cancer Res , vol.61 , pp. 1406-1411
    • Moss, S.F.1    Sordillo, E.M.2    Abdalla, A.M.3
  • 22
    • 0035142645 scopus 로고    scopus 로고
    • Ammonia as an accelerator of tumor necrosis factor alpha-induced apoptosis of gastric epithelial cells in Helicobacter pylori infection
    • Igarashi M., Kitada Y., Yoshiyama H., et al. Ammonia as an accelerator of tumor necrosis factor alpha-induced apoptosis of gastric epithelial cells in Helicobacter pylori infection. Infect Immun 69 (2001) 816-821
    • (2001) Infect Immun , vol.69 , pp. 816-821
    • Igarashi, M.1    Kitada, Y.2    Yoshiyama, H.3
  • 23
    • 0035430836 scopus 로고    scopus 로고
    • NF-kappaB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection
    • Lim J.W., Kim H., and Kim K.H. NF-kappaB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection. Free Radic Biol Med 31 (2001) 355-366
    • (2001) Free Radic Biol Med , vol.31 , pp. 355-366
    • Lim, J.W.1    Kim, H.2    Kim, K.H.3
  • 24
    • 85047691456 scopus 로고    scopus 로고
    • Helicobacter pylori persistence: biology and disease
    • Blaser M.J., and Atherton J.C. Helicobacter pylori persistence: biology and disease. J Clin Invest 113 (2004) 321-333
    • (2004) J Clin Invest , vol.113 , pp. 321-333
    • Blaser, M.J.1    Atherton, J.C.2
  • 25
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman K.B., and Ames B.N. The free radical theory of aging matures. Physiol Rev 78 (1998) 547-581
    • (1998) Physiol Rev , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 26
    • 0034733807 scopus 로고    scopus 로고
    • Redox-dependent signal transduction
    • Finkel T. Redox-dependent signal transduction. FEBS Lett 476 (2000) 52-54
    • (2000) FEBS Lett , vol.476 , pp. 52-54
    • Finkel, T.1
  • 27
    • 18344366874 scopus 로고    scopus 로고
    • Role of mitochondria in oxidative stress and aging
    • Lenaz G., Bovina C., D'Aurelio M., et al. Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci 959 (2002) 199-213
    • (2002) Ann N Y Acad Sci , vol.959 , pp. 199-213
    • Lenaz, G.1    Bovina, C.2    D'Aurelio, M.3
  • 28
    • 9144257277 scopus 로고    scopus 로고
    • Tissue distribution and putative physiological function of NOX family NADPH oxidases
    • Krause K.H. Tissue distribution and putative physiological function of NOX family NADPH oxidases. Jpn J Infect Dis 57 (2004) S28-S29
    • (2004) Jpn J Infect Dis , vol.57
    • Krause, K.H.1
  • 29
    • 15944367779 scopus 로고    scopus 로고
    • NADPH oxidase involvement in the pathology of Helicobacter pylori infection
    • Keenan J.I., Peterson II R.A., and Hampton M.B. NADPH oxidase involvement in the pathology of Helicobacter pylori infection. Free Radic Biol Med 38 (2005) 1188-1196
    • (2005) Free Radic Biol Med , vol.38 , pp. 1188-1196
    • Keenan, J.I.1    Peterson II, R.A.2    Hampton, M.B.3
  • 30
    • 16844385829 scopus 로고    scopus 로고
    • Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach
    • Salles N., Szanto I., Herrmann F., et al. Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. Exp Gerontol 40 (2005) 353-357
    • (2005) Exp Gerontol , vol.40 , pp. 353-357
    • Salles, N.1    Szanto, I.2    Herrmann, F.3
  • 31
    • 0035813159 scopus 로고    scopus 로고
    • A Ca (2+)-activated NADPH oxidase in testis, spleen, and lymph nodes
    • Banfi B., Molnar G., Maturana A., et al. A Ca (2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem 276 (2001) 37594-37601
    • (2001) J Biol Chem , vol.276 , pp. 37594-37601
    • Banfi, B.1    Molnar, G.2    Maturana, A.3
  • 32
    • 0033105874 scopus 로고    scopus 로고
    • NADPH oxidase: an update
    • Babior B.M. NADPH oxidase: an update. Blood 93 (1999) 1464-1476
    • (1999) Blood , vol.93 , pp. 1464-1476
    • Babior, B.M.1
  • 33
    • 14844355257 scopus 로고    scopus 로고
    • Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release
    • Allen L.A., Beecher B.R., Lynch J.T., et al. Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release. J Immunol 174 (2005) 3658-3667
    • (2005) J Immunol , vol.174 , pp. 3658-3667
    • Allen, L.A.1    Beecher, B.R.2    Lynch, J.T.3
  • 34
    • 0035076323 scopus 로고    scopus 로고
    • Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa
    • Danese S., Cremonini F., Armuzzi A., et al. Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa. Scand J Gastroenterol 36 (2001) 247-250
    • (2001) Scand J Gastroenterol , vol.36 , pp. 247-250
    • Danese, S.1    Cremonini, F.2    Armuzzi, A.3
  • 35
    • 33344468011 scopus 로고    scopus 로고
    • Small bowel bacterial overgrowth is not seen in healthy adults but is in disabled older adults
    • Mitsui T., Shimaoka K., Goto Y., et al. Small bowel bacterial overgrowth is not seen in healthy adults but is in disabled older adults. Hepatogastroenterology 53 (2006) 82-85
    • (2006) Hepatogastroenterology , vol.53 , pp. 82-85
    • Mitsui, T.1    Shimaoka, K.2    Goto, Y.3
  • 36
    • 0038315313 scopus 로고    scopus 로고
    • Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults
    • Parlesak A., Klein B., Schecher K., et al. Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults. J Am Geriatr Soc 51 (2003) 768-773
    • (2003) J Am Geriatr Soc , vol.51 , pp. 768-773
    • Parlesak, A.1    Klein, B.2    Schecher, K.3
  • 37
    • 0032958024 scopus 로고    scopus 로고
    • Small bowel bacterial overgrowth in subjects living in residential care homes
    • Lewis S.J., Potts L.F., Malhotra R., et al. Small bowel bacterial overgrowth in subjects living in residential care homes. Age Ageing 28 (1999) 181-185
    • (1999) Age Ageing , vol.28 , pp. 181-185
    • Lewis, S.J.1    Potts, L.F.2    Malhotra, R.3
  • 38
    • 58149093334 scopus 로고    scopus 로고
    • An update on cobalamin deficiency in adults
    • Dali-Youcef N., and Andres E. An update on cobalamin deficiency in adults. Qjm 102 (2009) 17-28
    • (2009) Qjm , vol.102 , pp. 17-28
    • Dali-Youcef, N.1    Andres, E.2
  • 40
    • 0242432348 scopus 로고    scopus 로고
    • Prevalence and mechanisms of hyperhomocysteinemia in elderly hospitalized patients
    • Salles-Montaudon N., Parrot F., Balas D., et al. Prevalence and mechanisms of hyperhomocysteinemia in elderly hospitalized patients. J Nutr Health Aging 7 (2003) 111-116
    • (2003) J Nutr Health Aging , vol.7 , pp. 111-116
    • Salles-Montaudon, N.1    Parrot, F.2    Balas, D.3
  • 43
    • 0345741404 scopus 로고    scopus 로고
    • Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection
    • Sipponen P., Laxen F., Huotari K., et al. Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection. Scand J Gastroenterol 38 (2003) 1209-1216
    • (2003) Scand J Gastroenterol , vol.38 , pp. 1209-1216
    • Sipponen, P.1    Laxen, F.2    Huotari, K.3
  • 44
    • 1542359600 scopus 로고    scopus 로고
    • Effects of ageing on gastrointestinal motor function
    • Madsen J.L., and Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing 33 (2004) 154-159
    • (2004) Age Ageing , vol.33 , pp. 154-159
    • Madsen, J.L.1    Graff, J.2
  • 45
    • 0038118146 scopus 로고    scopus 로고
    • Does age influence the gastric emptying of solids?
    • Chassagne P., Capet C., Verdonck A., et al. Does age influence the gastric emptying of solids?. Am J Gastroenterol 98 (2003) 1659-1661
    • (2003) Am J Gastroenterol , vol.98 , pp. 1659-1661
    • Chassagne, P.1    Capet, C.2    Verdonck, A.3
  • 46
    • 0036976301 scopus 로고    scopus 로고
    • Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test
    • Shimamoto C., Hirata I., Hiraike Y., et al. Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test. Gerontology 48 (2002) 381-386
    • (2002) Gerontology , vol.48 , pp. 381-386
    • Shimamoto, C.1    Hirata, I.2    Hiraike, Y.3
  • 47
    • 0032838741 scopus 로고    scopus 로고
    • Effects of aging and gastric lipolysis on gastric emptying of lipid in liquid meal
    • Nakae Y., Onouchi H., Kagaya M., et al. Effects of aging and gastric lipolysis on gastric emptying of lipid in liquid meal. J Gastroenterol 34 (1999) 445-449
    • (1999) J Gastroenterol , vol.34 , pp. 445-449
    • Nakae, Y.1    Onouchi, H.2    Kagaya, M.3
  • 48
    • 0031014558 scopus 로고    scopus 로고
    • Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults
    • Clarkston W.K., Pantano M.M., Morley J.E., et al. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Phys 272 (1997) R243-R248
    • (1997) Am J Phys , vol.272
    • Clarkston, W.K.1    Pantano, M.M.2    Morley, J.E.3
  • 49
    • 4544374217 scopus 로고    scopus 로고
    • Energy intake and appetite are related to antral area in healthy young and older subjects
    • Sturm K., Parker B., Wishart J., et al. Energy intake and appetite are related to antral area in healthy young and older subjects. Am J Clin Nutr 80 (2004) 656-667
    • (2004) Am J Clin Nutr , vol.80 , pp. 656-667
    • Sturm, K.1    Parker, B.2    Wishart, J.3
  • 51
    • 0036841498 scopus 로고    scopus 로고
    • Aging and neural control of the GI tract: III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species
    • Wiley J.W. Aging and neural control of the GI tract: III. Senescent enteric nervous system: lessons from extraintestinal sites and nonmammalian species. Am J Physiol Gastrointest Liver Physiol 283 (2002) G1020-G1026
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Wiley, J.W.1
  • 52
    • 0030603879 scopus 로고    scopus 로고
    • Preservation of the cervical vagus nerve in aged rats: morphometric and enzyme histochemical evidence
    • Soltanpour N., and Santer R.M. Preservation of the cervical vagus nerve in aged rats: morphometric and enzyme histochemical evidence. J Auton Nerv Syst 60 (1996) 93-101
    • (1996) J Auton Nerv Syst , vol.60 , pp. 93-101
    • Soltanpour, N.1    Santer, R.M.2
  • 53
    • 0036889708 scopus 로고    scopus 로고
    • Aging and neural control of the GI tract: IV. Clinical and physiological aspects of gastrointestinal motility and aging
    • Orr W.C., and Chen C.L. Aging and neural control of the GI tract: IV. Clinical and physiological aspects of gastrointestinal motility and aging. Am J Physiol Gastrointest Liver Physiol 283 (2002) G1226-G1231
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Orr, W.C.1    Chen, C.L.2
  • 54
    • 0038488561 scopus 로고    scopus 로고
    • Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons
    • Phillips R.J., Kieffer E.J., and Powley T.L. Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons. Auton Neurosci 106 (2003) 69-83
    • (2003) Auton Neurosci , vol.106 , pp. 69-83
    • Phillips, R.J.1    Kieffer, E.J.2    Powley, T.L.3
  • 55
    • 3142689189 scopus 로고    scopus 로고
    • Effects of Helicobacter pylori infection on gastric emptying rate in patients with non-ulcer dyspepsia
    • Leontiadis G.I., Minopoulos G.I., Maltezos E., et al. Effects of Helicobacter pylori infection on gastric emptying rate in patients with non-ulcer dyspepsia. World J Gastroenterol 10 (2004) 1750-1754
    • (2004) World J Gastroenterol , vol.10 , pp. 1750-1754
    • Leontiadis, G.I.1    Minopoulos, G.I.2    Maltezos, E.3
  • 56
    • 0030927524 scopus 로고    scopus 로고
    • A citric acid solution is an optimal test drink in the C-13-urea breath test for the diagnosis of Helicobacter pylori infection
    • Dominguez Munoz J.E., Leodolter A., Sauerbruch T., et al. A citric acid solution is an optimal test drink in the C-13-urea breath test for the diagnosis of Helicobacter pylori infection. Gut 40 (1997) 459-462
    • (1997) Gut , vol.40 , pp. 459-462
    • Dominguez Munoz, J.E.1    Leodolter, A.2    Sauerbruch, T.3
  • 57
    • 0026517111 scopus 로고
    • Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans
    • Cryer B., Redfern J.S., Goldschmiedt M., et al. Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 102 (1992) 1118-1123
    • (1992) Gastroenterology , vol.102 , pp. 1118-1123
    • Cryer, B.1    Redfern, J.S.2    Goldschmiedt, M.3
  • 58
    • 0034119475 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach: effects of aging and ulcers
    • Vogiagis D., Glare E.M., Misajon A., et al. Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach: effects of aging and ulcers. Am J Physiol Gastrointest Liver Physiol 278 (2000) G820-G827
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Vogiagis, D.1    Glare, E.M.2    Misajon, A.3
  • 59
    • 0030333175 scopus 로고    scopus 로고
    • Age-related changes in gastric blood flow in rats
    • Lee M. Age-related changes in gastric blood flow in rats. Gerontology 42 (1996) 289-293
    • (1996) Gerontology , vol.42 , pp. 289-293
    • Lee, M.1
  • 60
    • 36549079651 scopus 로고    scopus 로고
    • Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors
    • Tarnawski A., Pai R., Deng X., et al. Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors. Gastroenterology 133 (2007) 1938-1947
    • (2007) Gastroenterology , vol.133 , pp. 1938-1947
    • Tarnawski, A.1    Pai, R.2    Deng, X.3
  • 61
    • 0031766357 scopus 로고    scopus 로고
    • Differential expression of EGFR during early reparative phase of the gastric mucosa between young and aged rats
    • Liu L., Turner J.R., Yu Y., et al. Differential expression of EGFR during early reparative phase of the gastric mucosa between young and aged rats. Am J Physiol 275 (1998) G943-G950
    • (1998) Am J Physiol , vol.275
    • Liu, L.1    Turner, J.R.2    Yu, Y.3
  • 62
    • 16844386490 scopus 로고    scopus 로고
    • Regulation of gastrointestinal mucosal growth during aging
    • Majumdar A.P. Regulation of gastrointestinal mucosal growth during aging. J Physiol Pharmacol 4 54 Suppl (2003) 143-154
    • (2003) J Physiol Pharmacol , vol.4 , Issue.54 SUPPL , pp. 143-154
    • Majumdar, A.P.1
  • 63
    • 9644274090 scopus 로고    scopus 로고
    • Intrinsic ageing of gut epithelial stem cells
    • Kirkwood T.B. Intrinsic ageing of gut epithelial stem cells. Mech Ageing Dev 125 (2004) 911-915
    • (2004) Mech Ageing Dev , vol.125 , pp. 911-915
    • Kirkwood, T.B.1
  • 64
    • 0032715202 scopus 로고    scopus 로고
    • Induction of G(1) checkpoint in the gastric mucosa of aged rats
    • Xiao Z.Q., Yu Y., Khan A., et al. Induction of G(1) checkpoint in the gastric mucosa of aged rats. Am J Physiol 277 (1999) G929-G934
    • (1999) Am J Physiol , vol.277
    • Xiao, Z.Q.1    Yu, Y.2    Khan, A.3
  • 65
    • 0038102867 scopus 로고    scopus 로고
    • Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa
    • Xiao Z.Q., Li J., and Majumdar A.P. Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa. Am J Physiol Gastrointest Liver Physiol 285 (2003) G396-G403
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Xiao, Z.Q.1    Li, J.2    Majumdar, A.P.3
  • 66
    • 46049093776 scopus 로고    scopus 로고
    • Gastric mucosal defense and cytoprotection: bench to bedside
    • Laine L., Takeuchi K., and Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135 (2008) 41-60
    • (2008) Gastroenterology , vol.135 , pp. 41-60
    • Laine, L.1    Takeuchi, K.2    Tarnawski, A.3
  • 67
    • 0025801670 scopus 로고
    • Effect of colloidal bismuth subcitrate on age related gastric lesions in the rat
    • Hinsull S.M. Effect of colloidal bismuth subcitrate on age related gastric lesions in the rat. Gut 32 (1991) 355-360
    • (1991) Gut , vol.32 , pp. 355-360
    • Hinsull, S.M.1
  • 68
    • 0034045153 scopus 로고    scopus 로고
    • Aging alters gastric mucosal responses to epidermal growth factor and transforming growth factor-alpha
    • Turner J.R., Liu L., Fligiel S.E., et al. Aging alters gastric mucosal responses to epidermal growth factor and transforming growth factor-alpha. Am J Physiol Gastrointest Liver Physiol 278 (2000) G805-G810
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Turner, J.R.1    Liu, L.2    Fligiel, S.E.3
  • 69
    • 0024423865 scopus 로고
    • Aging: altered responsiveness of gastric mucosa to epidermal growth factor
    • Majumdar A.P., and Arlow F.L. Aging: altered responsiveness of gastric mucosa to epidermal growth factor. Am J Physiol 257 (1989) G554-G560
    • (1989) Am J Physiol , vol.257
    • Majumdar, A.P.1    Arlow, F.L.2
  • 70
    • 0026497750 scopus 로고
    • Role of tyrosine kinases in bombesin regulation of gastric mucosal proliferative activity in young and aged rats
    • Majumdar A.P., and Tureaud J. Role of tyrosine kinases in bombesin regulation of gastric mucosal proliferative activity in young and aged rats. Peptides 13 (1992) 795-800
    • (1992) Peptides , vol.13 , pp. 795-800
    • Majumdar, A.P.1    Tureaud, J.2
  • 71
    • 0242516074 scopus 로고    scopus 로고
    • Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesis
    • Majumdar A.P., Du J., Hatfield J.S., et al. Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesis. Dig Dis Sci 48 (2003) 856-864
    • (2003) Dig Dis Sci , vol.48 , pp. 856-864
    • Majumdar, A.P.1    Du, J.2    Hatfield, J.S.3
  • 72
    • 25644437787 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of gastrointestinal ulcer healing
    • Tarnawski A.S. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 1 50 Suppl (2005) S24-S33
    • (2005) Dig Dis Sci , vol.1 , Issue.50 SUPPL
    • Tarnawski, A.S.1
  • 73
    • 0037204743 scopus 로고    scopus 로고
    • Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole
    • Ishihara M., and Ito M. Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. Eur J Pharmacol 444 (2002) 209-215
    • (2002) Eur J Pharmacol , vol.444 , pp. 209-215
    • Ishihara, M.1    Ito, M.2
  • 74
    • 56949106960 scopus 로고    scopus 로고
    • Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol
    • Ishihara M., Kojima R., and Ito M. Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol. Eur J Pharmacol 601 (2008) 143-147
    • (2008) Eur J Pharmacol , vol.601 , pp. 143-147
    • Ishihara, M.1    Kojima, R.2    Ito, M.3
  • 75
    • 9444265320 scopus 로고    scopus 로고
    • Gastric cancer originating from bone marrow-derived cells
    • Houghton J., Stoicov C., Nomura S., et al. Gastric cancer originating from bone marrow-derived cells. Science 306 (2004) 1568-1571
    • (2004) Science , vol.306 , pp. 1568-1571
    • Houghton, J.1    Stoicov, C.2    Nomura, S.3
  • 76
    • 40449098148 scopus 로고    scopus 로고
    • Cultured bone marrow cell local implantation accelerates healing of ulcers in mice
    • Nishida T., Tsuji S., Tsujii M., et al. Cultured bone marrow cell local implantation accelerates healing of ulcers in mice. J Gastroenterol 43 (2008) 124-135
    • (2008) J Gastroenterol , vol.43 , pp. 124-135
    • Nishida, T.1    Tsuji, S.2    Tsujii, M.3
  • 77
    • 0020539303 scopus 로고
    • Regulation of gastric mucosal DNA synthesis during fasting and refeeding in rats
    • Majumdar A.P. Regulation of gastric mucosal DNA synthesis during fasting and refeeding in rats. Digestion 27 (1983) 36-43
    • (1983) Digestion , vol.27 , pp. 36-43
    • Majumdar, A.P.1
  • 79
    • 0029879722 scopus 로고    scopus 로고
    • Short-term caloric restriction augments age-related decreases in gastrin content and release
    • Chu K.U., Evers B.M., Ishizuka J., et al. Short-term caloric restriction augments age-related decreases in gastrin content and release. Mech Ageing Dev 87 (1996) 25-33
    • (1996) Mech Ageing Dev , vol.87 , pp. 25-33
    • Chu, K.U.1    Evers, B.M.2    Ishizuka, J.3
  • 80
    • 9644266858 scopus 로고    scopus 로고
    • Food intake and ageing-the role of the gut
    • Parker B.A., and Chapman I.M. Food intake and ageing-the role of the gut. Mech Ageing Dev 125 (2004) 859-866
    • (2004) Mech Ageing Dev , vol.125 , pp. 859-866
    • Parker, B.A.1    Chapman, I.M.2
  • 82
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y., Proenca R., Maffei M., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 83
    • 0033930048 scopus 로고    scopus 로고
    • Leptin secretion and leptin receptor in the human stomach
    • Sobhani I., Bado A., Vissuzaine C., et al. Leptin secretion and leptin receptor in the human stomach. Gut 47 (2000) 178-183
    • (2000) Gut , vol.47 , pp. 178-183
    • Sobhani, I.1    Bado, A.2    Vissuzaine, C.3
  • 84
    • 0032552112 scopus 로고    scopus 로고
    • The stomach is a source of leptin
    • Bado A., Levasseur S., Attoub S., et al. The stomach is a source of leptin. Nature 394 (1998) 790-793
    • (1998) Nature , vol.394 , pp. 790-793
    • Bado, A.1    Levasseur, S.2    Attoub, S.3
  • 85
    • 0034909166 scopus 로고    scopus 로고
    • Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve
    • Buyse M., Ovesjo M.L., Goiot H., et al. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 14 (2001) 64-72
    • (2001) Eur J Neurosci , vol.14 , pp. 64-72
    • Buyse, M.1    Ovesjo, M.L.2    Goiot, H.3
  • 86
    • 33845962613 scopus 로고    scopus 로고
    • Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients
    • Salles N., Menard A., Georges A., et al. Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. J Gerontol A Biol Sci Med Sci 61 (2006) 1144-1150
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 1144-1150
    • Salles, N.1    Menard, A.2    Georges, A.3
  • 87
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 88
    • 9644288053 scopus 로고    scopus 로고
    • Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat
    • Englander E.W., Gomez G.A., and Greeley Jr. G.H. Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat. Mech Ageing Dev 125 (2004) 871-875
    • (2004) Mech Ageing Dev , vol.125 , pp. 871-875
    • Englander, E.W.1    Gomez, G.A.2    Greeley Jr., G.H.3
  • 89
    • 53749108574 scopus 로고    scopus 로고
    • Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin
    • Schneider S.M., Al-Jaouni R., Caruba C., et al. Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin. Clin Nutr 27 (2008) 724-731
    • (2008) Clin Nutr , vol.27 , pp. 724-731
    • Schneider, S.M.1    Al-Jaouni, R.2    Caruba, C.3
  • 90
    • 0034878831 scopus 로고    scopus 로고
    • Gastric leptin and Helicobacter pylori infection
    • Azuma T., Suto H., Ito Y., et al. Gastric leptin and Helicobacter pylori infection. Gut 49 (2001) 324-329
    • (2001) Gut , vol.49 , pp. 324-329
    • Azuma, T.1    Suto, H.2    Ito, Y.3
  • 91
    • 13544267706 scopus 로고    scopus 로고
    • Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection
    • Nishi Y., Isomoto H., Uotani S., et al. Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection. World J Gastroenterol 11 (2005) 695-699
    • (2005) World J Gastroenterol , vol.11 , pp. 695-699
    • Nishi, Y.1    Isomoto, H.2    Uotani, S.3
  • 92
    • 19944427364 scopus 로고    scopus 로고
    • Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori
    • Osawa H., Nakazato M., Date Y., et al. Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori. J Clin Endocrinol Metab 90 (2005) 10-16
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 10-16
    • Osawa, H.1    Nakazato, M.2    Date, Y.3
  • 93
    • 8744241612 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa
    • Tatsuguchi A., Miyake K., Gudis K., et al. Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. Am J Gastroenterol 99 (2004) 2121-2127
    • (2004) Am J Gastroenterol , vol.99 , pp. 2121-2127
    • Tatsuguchi, A.1    Miyake, K.2    Gudis, K.3
  • 94
    • 17144402257 scopus 로고    scopus 로고
    • Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma
    • Isomoto H., Ueno H., Nishi Y., et al. Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma. World J Gastroenterol 11 (2005) 1644-1648
    • (2005) World J Gastroenterol , vol.11 , pp. 1644-1648
    • Isomoto, H.1    Ueno, H.2    Nishi, Y.3
  • 95
    • 0038639060 scopus 로고    scopus 로고
    • Plasma ghrelin following cure of Helicobacter pylori
    • Nwokolo C.U., Freshwater D.A., O'Hare P., et al. Plasma ghrelin following cure of Helicobacter pylori. Gut 52 (2003) 637-640
    • (2003) Gut , vol.52 , pp. 637-640
    • Nwokolo, C.U.1    Freshwater, D.A.2    O'Hare, P.3
  • 96
    • 1642533654 scopus 로고    scopus 로고
    • Ghrelin and Helicobacter pylori
    • author reply 315
    • Murray C.D., and Emmanuel A.V. Ghrelin and Helicobacter pylori. Gut 53 (2004) 315 author reply 315
    • (2004) Gut , vol.53 , pp. 315
    • Murray, C.D.1    Emmanuel, A.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.