Prevalence of Low Vitamin B12 and High Homocysteine in Serum in an Elderly Male Population: Association with Atrophic Gastritis and Helicobacter pylori Infection

Scandinavian Journal of Gastroenterology

Volumn 38, Issue 12, 2003, Pages 1209-1216

  Sipponen, P ^a   Laxen F ^b   Huotari, K ^b   Harkonen M ^b  

^a JORVI HOSPITAL   (Finland)

^b NONE

Author keywords

Atrophic gastritis; Folate; Homocysteine; Malabsorption; Vitamin B12; Vitamin deficiency

Indexed keywords

BACTERIUM ANTIBODY; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PEPSINOGEN I;

ADULT; AGED; ARTICLE; ATROPHIC GASTRITIS; BLOOD LEVEL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; ENZYME ASSAY; FINLAND; FOLIC ACID BLOOD LEVEL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; RANDOMIZATION; SAMPLE; SENESCENCE; VITAMIN BLOOD LEVEL;

AGED; FOLIC ACID; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PEPSINOGEN A; VITAMIN B 12 DEFICIENCY;

EID: 0345741404     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520310007224     Document Type: Article

References (37)

1. Carmel R. Cobolamin, the stomach, and aging. Am J Clin Nutr 1997;66:750-9.
2. Matthews JH. Cobolamin and folate deficiency in the elderly. Baillieres Clin Hematol 1995;8:579-697.
3. Nehler MR, Taylor LM, Jr, Potter JM. Homocysteinemia as a risk factor for atherosclerosis: a review. J Cardiovasc Surg 1997;5: 559-67.
4. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J 2002;325:1202-6.
5. Prins SD, Den Heijer T, Hofman A, Kouldstaal PJ, Jolles J, Clarke L, et al. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002;59:1375-80.
6. Alfthamn G, Aro A, Fred K. Plasma homocysteine and cardiovascular disease mortality. The Lancet 1997. p. 349.
7. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton I, Ueland PM. Folate, vitamin B12, and serum homocysteine levels in confirmed Alzheimer's disease. Arch Neurol 1998;55:1449-55.
8. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ, Homocysteine B, vitamin status, and cognitive function in the elderly. Am J Clin Neurol 2002;75:908-13.
9. McCaddon A, Hudson P, Davis G, Hughes A, Williams JH, Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 2001;12:309-13.
10. Wang HX, Wahlin Å, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology 2001;56:1188-94.
11. Vollset SE, Refsum H, Tverdal A, Nygard O, Nordrehaug JE, Tell GS, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland homocysteine study. Am J Clin Nutr 2001;74:130-6.
12. See: www.homocysteine.net and www.vitaminB12.com.
13. Bolander-Gouaille C. Focus on homocysteine and the vitamins involved in its metabolism. Berlin: Springer Verlag; 2002.
14. Varis K, Samloff IM, Ihamäki T, Siurala M. An appraisal of tests for severe atrophic gastritis in relatives of pernicious anemia. Dig Dis Sci 1979;24:187-91.
15. Yao Y, Yao SL, Yao SS, Yao G, Lou W. Prevalence of vitamin B12 deficiency among geriatric outpatients. J Fam Pract 1992;35: 524-8.
16. Regland B, Gottfries CG, Lindstedt G. Dementia patients with low serum cobolamin concentration: relationship to atrophic gastritis. Aging 1992;4:35-41.
17. Krasinski SD, Russell RM, Samloff IM, Jacob RA, Dallal GE, McGandy RB, et al. Fundic atrophic gastritis in elderly population. Effect on hemoglobin and several serum nutritional indicators. Am Geriatr Soc 1986;34:800-6.
18. Kastrup W, Mobacken H, Stockbrugger R, Swolin B, Westlin J. Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anemia. Acta Med Scand 1986;220: 261-8.
19. van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I, et al. Role of cobolamin intake and atrophic gastritis in mild cobolamin deficiency in older Dutch subjects. Am J Clin Nutr 1998;68:328-34.
20. Valle J, Kekki M, Sipponen P, Ihamäki T, Siurala M. Long-term course and consequences of Helicobacter pylori gastritis. Results from a 32-year follow-up study. Scand J Gastroenterol 1996;31: 546-50.
21. Siurala M, Lehtola J, Ihamäki T. Atrophic gastritis and its sequelae. Scand J Gastroenterol 1987;22:1-12.
22. + Helicobacter pylori. Scand J Gastroenterol 2001;36:928-33.
23. Borody T, Andrews P, Jankiewicz E, Ferch N, Carroll M. Apparent reversal of early gastric mucosal atrophy after triple therapy for Helicobacter pylori. Am J Gastroenterol 1993;88: 1266-8.
24. Kokkola A, Sipponen P, Rautelin H, Härkönen M, Kosunen TU, Haapiainen R, et al. The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 2002;16:515-20.
25. Sipponen P, Ranta P, Helske T, Kääriäinen I, Mäki T, Linnala A, et al. Serum levels of amidated gastrin-17 and pepsinogen 1 in atrophic gastritis. An observational case-control study. Scand J Gastroenterol 2002;37:785-91.
26. Price AB. The Sydney System: histological division. Gastroenterol Hepatol 1991;6:209-22.
27. Baik HW, Russell RM. Vitamin B12 in the elderly. Annu Rev Nutr 1999;19:357-77.
28. Morris MS, Jacques PF, Rosenberg IH, Selbub J. Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr 2002;132:2799-803.
29. Nilsson-Ehle H, Landahl S, Lindstedt G, Netterblad L, Stockbruegger R, Westin J, et al. Low serum cobolamin levels in a population of 70- and 75-year-old subjects. Gastrointestinal causes and hematological effects. Dig Dis Sci 1989;34:716-23.
30. Nilsson-Ehle H, Jagenburg R, Landahl S, Lindstedt S, Svanborg A, Westin J. Serum cobolamins in the elderly: a longitudinal study of a representative population sample from age 70 to 81. Eur J Haematol 1991;47:10-16.
31. Kekki M, Samloff IM, Varis K, Ihamäki T. Serum pepsinogen 1 and gastrin in screening of severe atrophic corpus gastritis. Scand J Gastroenterol 1991;186:109-16.
32. Miki K, Ichinose M, Shimizu A, Huang SC, Oka H, Furihata C, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterology 1987;22:133-41.
33. Kekki M, Samloff IM, Varis K, Ihamäki T. Serum pepsinogen I and gastrin in screening of severe atrophic corpus gastritis. Scand J Gastroenterol 1991;186:109-16.
34. Borch K, Axelsson CK, Halgreen H, Damkjaer Nielsen MD, Ledin T, Szesci PB. The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. Scand J Gastroenterol 1989; 24:870-6.
35. Varis K, Sipponen P, Laxén F, Samloff IM, Huttunen J, Taylor PR, et al. and the Helsinki Gastritis Study Group. Implications of serum pepsinogen I in early endoscopie diagnosis of gastric cancer and dysplasia. Scand J Gastroenterol 2000;35:950-6.
36. Kokkola A, Rautelin H, Puolakkainen P, Sipponen P, Färkkilä M, Haapiainen R, et al. Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea, breath test, and serology. Scand J Gastroenterol 2000;35: 138-41.
37. Malfertheiner P, Megraud F, O'Morain C, Hungin AP, Jones R, Axon A, et al. Current concept in the management of Helicobacter pylori: The Maastricht 2 Consensus Report. Aliment Pharmacol Ther 2002;16:167-80.