Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: Discovery, characterization and preliminary SAR of a promising lead

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6185-6188

  Thoma, Gebhard ^a   Baenteli, Rolf ^a   Lewis, Ian ^a   Wagner, Trixie ^a   Oberer, Lukas ^a   Blum, Wolfgang ^a   Glickman, Fraser ^a   Streiff, Markus B ^a   Zerwes, Hans Guenter ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CXCL10; CXCL11; CXCL9; CXCR3; Ergoline; LSD

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; ERGOLINE DERIVATIVE; UREA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIVER MICROSOME; MOLECULE; MOUSE; NONHUMAN; RAT; STEREOSPECIFICITY;

ANIMALS; DOGS; DRUG DISCOVERY; ERGOLINES; HUMANS; MICE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; RATS; RECEPTORS, CXCR3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749109221     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.002     Document Type: Article

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