Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4- one derivatives as CXCR3 chemokine receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2910-2913

  Storelli, Stefania ^a   Verdijk, Pauline ^b   Verzijl, Dennis ^a   Timmerman, Henk ^a   Van De Stolpe, Andrea C ^a   Tensen, Cornelis P ^b   Smit, Martine J ^a   De Esch, Iwan J P ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chemokine; CXCR3; SAR; Synthesis

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR3; DECANOIC ACID; QUINAZOLINONE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; RADIOASSAY; STRUCTURE ACTIVITY RELATION;

HUMANS; QUINAZOLINES; RECEPTORS, CHEMOKINE; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19544362723     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.070     Document Type: Article

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