Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2252-2257

  Wijtmans, Maikel ^a   Verzijl, Dennis ^a   van Dam, Cindy M E ^a   Bosch, Leontien ^a   Smit, Martine J ^a   Leurs, Rob ^a   de Esch, Iwan J P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

CXCR3; GPCR; Polycycloaliphatic; Reductive amination

Indexed keywords

ADAMANTANE DERIVATIVE; ALIPHATIC COMPOUND; BICYCLIC (ISO)BORNYL DERIVATIVE; CHEMOKINE RECEPTOR CXCR3; TRICYCLIC 2 ADAMANTANE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS;

ADAMANTANE; AMINATION; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BORNANES; CELL LINE; HUMANS; POLYCYCLIC COMPOUNDS; RECEPTORS, CXCR3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 63149166891     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.093     Document Type: Article

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