Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients

American Journal of Transplantation

Volumn 8, Issue 8, 2008, Pages 1593-1603

  Kwun, J ^a   Hazinedaroglu, S M ^a   Schadde, E ^a   Kayaoglu, H A ^a   Fechner, J ^a   Hu, H Z ^a   Roenneburg, D ^a   Torrealba, J ^b   Shiao, L ^c   Hong, X ^c   Peng, R ^c   Szewczyk, J W ^c   Sullivan, K A ^c   DeMartino, J ^c   Knechtle, S J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Health   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acute rejection; Cardiac allograft; Cell trafficking; Mouse; T cell graft infiltration

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CONTROLLED STUDY; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTERFERON PRODUCTION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; INTERFERON-GAMMA; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, CXCR3; TRANSPLANTATION, HOMOLOGOUS;

EID: 48349137100     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02250.x     Document Type: Article

References (41)

1. Luster AD. Chemokines - Chemotactic cytokines that mediate inflammation. N Engl J Med 1998 338 : 436 445.
2. Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol 2001 2 : 108 115.
3. Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: Present and future therapeutic targets. Nat Immunol 2005 6 : 1182 1190.
4. Hancock WW. Chemokine receptor-dependent alloresponses. Immunol Rev 2003 196 : 37 50.
5. Grone HJ, Weber C, Weber KS et al. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: Blocking monocyte arrest and recruitment. FASEB J 1999 13 : 1371 1383.
6. Panzer U, Reinking RR, Steinmetz OM et al. CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection. Transplantation 2004 78 : 1341 1350.
7. Akalin E, Hendrix RC, Polavarapu RG et al. Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology. Transplantation 2001 72 : 948 953.
8. Hoffmann U, Segerer S, Rummele P et al. Expression of the chemokine receptor CXCR3 in human renal allografts - a prospective study. Nephrol Dial Transplant 2006 21 : 1373 1381.
9. Hancock WW, Lu B, Gao W et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000 192 : 1515 1520.
10. Akashi S, Sho M, Kashizuka H et al. A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection. Transplantation 2005 80 : 378 384.
11. Fischereder M, Luckow B, Hocher B et al. CC chemokine receptor 5 and renal-transplant survival. Lancet 2001 357 : 1758 1761.
12. Luckow B, Joergensen J, Chilla S et al. Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol 2004 34 : 2568 2578.
13. Amano H, Bickerstaff A, Orosz CG, Novick AC, Toma H, Fairchild RL. Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J Immunol 2005 174 : 6499 6508.
14. Liu L, Huang D, Matsui M et al. Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR3-/- mice with experimental autoimmune encephalomyelitis. J Immunol 2006 176 : 4399 4409.
15. Wareing MD, Lyon AB, Lu B, Gerard C, Sarawar SR. Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice. J Leukoc Biol 2004 76 : 886 895.
16. Chakravarty SD, Xu J, Lu B, Gerard C, Flynn J, Chan J. The chemokine receptor CXCR3 attenuates the control of chronic mycobacterium tuberculosis infection in BALB/c mice. J Immunol 2007 178 : 1723 1735.
17. Duffner U, Lu B, Hildebrandt GC et al. Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol 2003 31 : 897 902.
18. Baker MS, Chen X, Rotramel AR et al. Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients. Surgery 2003 134 : 126 133.
19. Agostini C, Calabrese F, Rea F et al. Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection. Am J Pathol 2001 158 : 1703 1711.
20. Jiankuo M, Xingbing W, Baojun H et al. Peptide nucleic acid antisense prolongs skin allograft survival by means of blockade of CXCR3 expression directing T cells into graft. J Immunol 2003 170 : 1556 1565.
21. Hildebrandt GC, Corrion LA, Olkiewicz KM et al. Blockade of CXCR3 receptor: Ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol 2004 173 : 2050 2059.
22. Shiao LL, Cascieri MA, Trumbauer M, Chen H, Sullivan KA. Generation of mice expressing the human glucagon receptor with a direct replacement vector. Transgenic Res 1999 8 : 295 302.
23. Winters GL, Marboe CC, Billingham ME. The International Society for Heart and Lung Transplantation grading system for heart transplant biopsy specimens: Clarification and commentary. J Heart Lung Transplant 1998 17 : 754 760.
24. Kwun J, Knechtle SJ, Hu H. Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. Transplantation 2006 81 : 590 598.
25. Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR. CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J Immunol 2006 176 : 4235 4243.
26. Taub DD, Turcovski-Corrales SM, Key ML, Longo DL, Murphy WJ. Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro. J Immunol 1996 156 : 2095 2103.
27. Bromley SK, Peterson DA, Gunn MD, Dustin ML. Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. J Immunol 2000 165 : 15 19.
28. Gao W, Faia KL, Csizmadia V et al. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 2001 72 : 1199 1205.
29. Campbell JD, Gangur V, Simons FE, HayGlass KT. Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop. FASEB J 2004 18 : 329 331.
30. Dar WA, Knechtle SJ. CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. Immunology 2007 120 : 467 485.
31. Kwun J, Hu H, Schadde E et al. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. J Immunol 2007 179 : 8016 8025.
32. Gangur V, Simons FE, HayGlass KT. Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses. FASEB J 1998 12 : 705 713.
33. Gangur V, Simons FE, HayGlass KT. IP-10 mediated reinforcement of human type 1 cytokine synthesis to environmental allergens among non-atopic subjects. Int Arch Allergy Immunol 1999 118 (2-4 387 390.
34. Abdi R, Means TK, Ito T et al. Differential role of CCR2 in islet and heart allograft rejection: Tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol 2004 172 : 767 775.
35. Zhang Z, Kaptanoglu L, Tang Y et al. IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection. Gastroenterology 2004 126 : 809 818.
36. Moser B, Loetscher M, Piali L, Loetscher P. Lymphocyte responses to chemokines. Int Rev Immunol 1998 16 (3-4 323 344.
37. Loetscher M, Gerber B, Loetscher P et al. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated T-lymphocytes. J Exp Med 1996 184 : 963 969.
38. Qin S, Rottman JB, Myers P et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 1998 101 : 746 754.
39. Miura M, Morita K, Kobayashi H et al. Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection. J Immunol 2001 167 : 3494 3504.
40. Chen D, Ding Y, Schroppel B et al. Differential chemokine and chemokine receptor gene induction by ischemia, alloantigen, and gene transfer in cardiac grafts. Am J Transplant 2003 3 : 1216 1229.
41. de Lemos C, Christensen JE, Nansen A et al. Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice. J Immunol 2005 175 : 1767 1775.