Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2414-2419

  Hayes, Martin E ^a   Breinlinger, Eric C ^a   Wallace, Grier A ^a   Grongsaard, Pintipa ^a   Miao, Wenyan ^a   McPherson, Michael J ^a   Stoffel, Robert H ^a   Green, David W ^a   Roth, Gregory P ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

2 Iminobenzimidazole; Benzimidazole; Chemokine; Chemokine antagonist; CXCL10; CXCR3; IP 10; Multiple sclerosis

Indexed keywords

2 IMINOBENZIMIDAZOLE DERIVATIVE; AMIDE; BENZIMIDAZOLE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR3; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG POTENCY; DRUG SCREENING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZIMIDAZOLES; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MODELS, CHEMICAL; QUINOLINES; RADIOLIGAND ASSAY; RECEPTORS, CXCR3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41149099605     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.049     Document Type: Article

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