Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells

Journal of Radiation Research

Volumn 50, Issue 5, 2009, Pages 477-486

  Monzen, Satoru ^a   Takahashi, Kenji ^a   Yoshino, Hironori ^a   Kasai Eguchi, Kiyomi ^b   Abe, Yoshinao ^a   Maruyama, Atsushi ^a   Itoh, Ken ^a   Kashiwakura, Ikuo ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Heavy ion beam; Hematopoiesis; Megakaryocytopoiesis; mRNA

Indexed keywords

BLOOD; GENE EXPRESSION; ION BEAMS; ION BOMBARDMENT; STEM CELLS; VIRUSES;

BIOLOGICAL EFFECTS; CYTOKINE RECEPTOR; HAEMATOPOIESIS; HEAVY-ION BEAMS; HEMATOPOIETIC STEM/PROGENITOR CELLS; ION BEAM IRRADIATION; LET RADIATION; MEGAKARYOCYTOPOIESIS; MRNA; MRNA EXPRESSION;

HEAVY IONS;

FRIEND MURINE LEUKEMIA VIRUS;

HEAVY ION; MESSENGER RNA;

ARTICLE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; PHYSIOLOGY; RADIATION EXPOSURE; THROMBOCYTOPOIESIS;

CELLS, CULTURED; GENE EXPRESSION REGULATION; HEAVY IONS; HEMATOPOIETIC STEM CELLS; HUMANS; RNA, MESSENGER; THROMBOPOIESIS;

EID: 71749103659     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.09058     Document Type: Article

References (44)

1. Kanai, T., Endo, M., Minohara, S., Miyahara, N., Koyama-Ito, H., Tomura, H., Matsufuji, N., Futami, Y., Fukumura, A. and Kawachi, K. (1999) Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44: 201-210.
2. Amaldi, U. (2004) Future trends in cancer therapy with particle accelerators. Z. Med. Phys. 14: 7-16.
3. Schulz-Ertner, D., Jäkel, O. and Schlegel, W. (2006) Radiation therapy with charged particles. Semin. Radiat. Oncol. 16: 249-259.
4. Jäkel, O., Karger, C. P. and Debus, J. (2008) The future of heavy ion radiotherapy. Med. Phys. 35: 5653-5663.
5. Wojcik, A., Gregoire, E., Hayata, I., Roy, L., Sommer, S., Stephan, G. and Voisin, P. (2004) Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents. Cytogenet. Genome. Res. 104: 200-205.
6. Hérodin, F. and Drouet, M. (2005) Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 33: 1071-1080.
7. Cucinotta, F. A. and Durante, M. (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet. Oncol. 7: 431-435.
8. Wagemaker, G. (1995) Heterogeneity of radiation sensitivity of hemopoietic stem cell subsets. Stem Cells 13(Suppl. 1): 257-260.
9. Mori, M. and Desaintes, C. (2004) Gene expression in response to ionizing radiation: an overview of molecular features in hematopoietic cells. J. Biol. Regul. Homeost. Agents. 18: 363-371.
10. Buschfort-Papewalis, C., Moritz, T., Liedert, B. and Thomale, J. (2002) Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response. Blood 100: 845-853.
11. Kashiwakura, I., Kuwabara, M., Inanami, O., Murakami, M., Hayase, Y., Takahashi, T. A. and Takagi, Y. (2000) Radiation sensitivity of megakaryocyte colony-forming cells in human placental and umbilical cord blood. Radiat. Res. 153: 144-152.
12. Hofmann, W. K., Ottmann, O. G. and Hoelzer, D. (1999) Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies? Leukemia 13: 14-18.
13. Demetri, G. D. (2001) Targeted approaches for the treatment of thrombocytopenia. Oncologist 6(Suppl 5): 15-23.
14. Kuter, D. J. and Begley, C. G. (2002) Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100: 3457-3469.
15. Heal, J. M. and Blumberg, N. (2004) Optimizing platelet transfusion therapy. Blood. Rev. 18: 149-165.
16. Kojima, Y., Itoh, H. and Fukushima, T. (2003) Perioperative management of patients with idiopathic thrombocytopenic purpura. Nippon. Rinsho. 61: 632-637.
17. Takahashi, K., Monzen, S., Eguchi-Kasai, K., Abe, Y. and Kashiwakura, I. (2007) Severe damage of human megakaryo-cytopoiesis and thrombopoiesis by heavy-ion beam radiation. Radiat. Res. 168: 545-551.
18. Takahashi, K., Monzen, S., Yoshino, H., Abe, Y., Eguchi-Kasai K. and Kashiwakura, I. (2008) Effects of a 2-step culture with cytokine combinations on megakaryocytopoiesis and thrombopoiesis from carbon-ion beam-irradiated human hematopoietic stem/progenitor cells. J. Radiat. Res. (Tokyo) 49: 417-424.
19. Zhang, D. E., Hohaus, S., Voso, M. T., Chen, H. M., Smith, L. T., Hetherington, C. J. and Tenen, D. G. (1996) Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr. Top. Microbiol. Immunol. 211: 137-147.
20. Kyba, M., Perlingeiro, R. C. R. and Daley, G. Q. (2002) HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 109: 29-37.
21. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y. and Suda, T. (2004) Tie2/Angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-161.
22. Kaushansky, K. (2008) Historical review: megakaryopoiesis and thrombopoiesis. Blood 111: 981-986.
23. + cells from human placental and umbilical cord blood. Bioelectromagnetics. 30: 280-285.
24. Furusawa, Y., Fukutsu, K., Aoki, M., Itsukaichi, H., Eguchi-Kasai, K., Ohara, H., Yatagai, F., Kanai, T. and Ando, K. (2000) Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Neion beams. Radiat. Res. 154: 485-496.
25. Petzer, A. L., Hogge, D. E., Landsdorp, P. M., Reid, D. S. and Eaves, C. J. (1996) Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc. Natl. Acad. Sci. U.S.A. 93: 1470-1474.
26. van den Oudenrijn, S., de Haas, M., Calafat, J., van der Schoot, C. E. and von dem Borne, A. E. (1999) A combination of megakaryocyte growth and development factor and inter-leukin-1 is sufficient to culture large numbers of megakaryo-cytic progenitors and megakaryocytes for transfusion purposes. Br. J. Haematol. 106: 553-563.
27. Gratama, J. W., Sutherland, D. R., Keeney, M. and Papa, S. Flow cytometric enumeration and immunophenotyping of hematopoietic stem and progenitor cells. (2001) J. Biol.Regul. Homeost. Agents. 15: 14-22.
28. + human mast cells from hematopoietic progenitor cells. Exp. Hematol. 33: 413-421.
29. Kremer, E., Baker, E., D'Andrea, R. J., Slim, R., Phillips, H., Moretti, P. A. B., Lopez, A. F., Petit, C., Vadas, M. A., Sutherland, G. R. and Goodall, G. J. (1993) A cytokine receptor gene cluster in the X-Y pseudoautosomal region? Blood 82: 22-28.
30. Arai, F. and Suda, T. (2007) Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci. 1106: 41-53.
31. Pimanda, J. E., Ottersbach, K., Knezevic, K., Kinston, S., Chan, W. Y. I., Wilson, N. K., Landry, J.-R., Wood, A. D., Kolb-Kokocinski, A., Green, A. R., Tannahill, D., Lacaud, G., Kouskoff, V. and Gottgens, B. (2007) Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc. Nat. Acad. Sci. U.S.A. 104: 17692-17697.
32. Donaldson, I. J., Chapman, M., Kinston, S., Landry, J. R., Knezevic, K., Piltz, S., Buckley, N., Green, A. R. and Gottgens, B. (2005) Genome-wide identification of cisregulatory sequences controlling blood and endothelial development. Hum. Molec. Genet. 14: 595-601.
33. Göttgens, B., Nastos, A., Kinston, S., Piltz, S., Delabesse, E. C., Stanley, M., Sanchez, M. J., Ciau-Uitz, A., Patient, R. and Green, A. R. (2002) Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO. J. 21: 3039-3050.
34. Guillon, N., Tirode, F., Boeva, V., Zynovyev, A., Barillot, E. and Delattre, O. (2009) The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. PLoS. ONE. 4: e4932.
35. Surh, Y. J., Kundu, J. K., Na, H. K. and Lee, J. S. (2005) Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J. Nutr. 135: 2993S-3001S.
36. Fiorentini, D., Prata, C., Maraldi, T., Zambonin, L., Bonsi, L., Hakim, G. and Landi, L. (2004) Contribution of reactive oxygen species to the regulation of Glut1 in two hemopoietic cell lines differing in cytokine sensitivity. Free. Radic. Biol. Med. 37: 1402-1411.
37. Katavetin, P., Inagi, R., Miyata, T., Shao, J., Sassa, R., Adler, S., Eto, N., Kato, H., Fujita, T. and Nangaku, M. (2007) Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress. Biochem. Biophys. Res. Commun. 359: 928-934.
38. Long, D. J. 2nd., Gaikwad, A., Multani, A., Pathak, S., Montgomery, C. A., Gonzalez, F. J. and Jaiswal, A. K. (2002) Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. Cancer. Res. 62: 3030-3036.
39. Chen, C. and Kong, A. N. (2004) Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic. Biol. Med. 36:1505-1516.
40. Lee, J.-S., Surh, Y.-J., Nrf2 as a novel molecular target for chemoprevention. Cancer. Lett. 224: 171-184.
41. Marrot, L., Jones, C., Perez, P. and Meunier, J. R. (2008) The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis. Pigment. Cell. Melanoma. Res. 21: 79-88.
42. Kagiya, G., Ogawa, R., Ito, S., Fukuda, S., Hatashita, M., Tanaka, Y., Yamamoto, K. and Kondo, T. (2009) Identification of a cis-acting element responsive to ultrasound in the 5'-flanking region of the human heme oxygenase-1 gene. Ultra-sound. Med. Biol. 35: 155-164.
43. O'Brien, J. J., Baglole, C. J., Garcia-Bates, T. M., Blumberg, N., Francis, C. W. and Phipps, R. P. (2009) 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J. Thromb. Haemost. 7: 182-189.
44. Hirayama, R., Ito, A., Tomita, M., Tsukada, T., Yatagai, F., Noguchi, M., Matsumoto, Y., Kase, Y., Ando, K., Okayasu, R. and Furusawa, Y. (2009) Contributions of direct and indirect actions in cell killing by high-LET radiations. Radiat. Res. 171: 212-218.