15-deoxy-Δ12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis

Journal of Thrombosis and Haemostasis

Volumn 7, Issue 1, 2009, Pages 182-189

  O'Brien, J J ^a   Baglole, C J ^a   Garcia Bates, T M ^a   Blumberg, N ^a   Francis, C W ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Heme oxygenase; Megakaryocyte; Platelet; Thrombopoiesis

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; HEME OXYGENASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; DRUG DERIVATIVE; PROSTAGLANDIN D2; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MEGAKARYOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTOPOIESIS; UMBILICAL CORD BLOOD; UPREGULATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; PHYSIOLOGY; THROMBOCYTE;

BLOOD PLATELETS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HUMANS; MEGAKARYOCYTES; PROSTAGLANDIN D2; REACTIVE OXYGEN SPECIES; THROMBOPOIESIS;

EID: 57749190574     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2008.03191.x     Document Type: Article

References (30)

1. O'Brien JJ, Spinelli SL, Joanna T, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. 15-deoxy-delta 12,14 -PGJ2 enhances platelet production from megakaryocytes. Blood 2008; 112: 4051-60.
2. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995; 83: 803-12.
3. Fukushima M. Biological activities and mechanisms of action of PGJ2 and related compounds: An update. Prostaglandins Leukot Essent Fatty Acids 1992; 47: 1-12.
4. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992; 358: 771-4.
5. Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood 2004; 104: 1361-8.
6. Colville-Nash PR, Qureshi SS, Willis D, Willoughby DA. Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: Correlation with induction of heme oxygenase 1. J Immunol 1998; 161: 978-84.
7. Koizumi T, Negishi M, Ichikawa A. Induction of heme oxygenase by delta 12-prostaglandin J2 in porcine aortic endothelial cells. Prostaglandins 1992; 43: 121-31.
8. Abraham NG, Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008; 60: 79-127.
9. Kawashima A, Oda Y, Yachie A, Koizumi S, Nakanishi I. Heme oxygenase-1 deficiency: The first autopsy case. Hum Pathol 2002; 33: 125-30.
10. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999; 103: 129-35.
11. Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost 2008; 99: 86-95.
12. Garcia-Bates TM, Bernstein SH, Phipps RP. Peroxisome proliferator-activated receptor gamma (PPARg) overexpression suppresses growth and induces apoptosis in human multiple myeloma cells. Clin Cancer Res 2008; 14: 6414-25.
13. Goh BJ, Tan BT, Hon WM, Lee KH, Khoo HE. Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis. World J Gastroenterol 2006; 12: 588-94.
14. Jozkowicz A, Huk I, Nigisch A, Weigel G, Weidinger F, Dulak J. Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxid Redox Signal 2002; 4: 577-85.
15. Motterlini R, Foresti R, Vandegriff K, Intaglietta M, Winslow RM. Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. Am J Physiol 1995; 269(2 Pt 2): H648-55.
16. Zeuner A, Signore M, Martinetti D, Bartucci M, Peschle C, De Maria R. Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor. Cancer Res 2007; 67: 4767-73.
17. Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, Uchida K. A15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. J Biol Chem 2002; 277: 10459-66.
18. Ray DM, Akbiyik F, Phipps RP. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. J Immunol 2006; 177: 5068-76.
19. Tsutsui K. Affinity chromatography of heme-binding proteins: Synthesis of hemin-agarose. Methods Enzymol 1986; 123: 331-8.
20. Drummond GS, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci U S A 1981; 78: 6466-70.
21. Drummond GS, Kappas A. Chemoprevention of neonatal jaundice: Potency of tin-protoporphyrin in an animal model. Science 1982; 217: 1250-2.
22. Kitamura Y, Kakimura J, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neurosci Lett 1999; 262: 129-32.
23. Lee TS, Tsai HL, Chau LY. Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. J Biol Chem 2003; 278: 19325-30.
24. Li L, Julien B, Grenard P, Teixeira-Clerc F, Mallat A, Lotersztajn S. Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. J Hepatol 2004; 41: 407-13.
25. Patel SR, Hartwig JH, Italiano JE Jr. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 2005; 115: 3348-54.
26. Maxey KM, Hessler E, MacDonald J, Hitchingham L. The nature and composition of 15-deoxy-Delta(12,14)PGJ(2). Prostaglandins Other Lipid Mediat 2000; 62: 15-21.
27. Farkas I, Maroti Z, Katona M, Endreffy E, Monostori P, Mader K, Túri S. Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome. Eur J Pediatr 2008; 167: 1379-83.
28. Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, Pisano B, Chatterjee PK, Thiemermann C. Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J 2002; 16: 1027-40.
29. Peng L, Mundada L, Stomel JM, Liu JJ, Sun J, Yet SF, Fay WP. Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. Antioxid Redox Signal 2004; 6: 729-35.
30. True AL, Olive M, Boehm M, San H, Westrick RJ, Raghavachari N, Xu X, Lynn EG, Sack MN, Munson PJ, Gladwin MT, Nabel EG. Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide. Circ Res 2007; 101: 893-901.