Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation

Radiation Research

Volumn 168, Issue 5, 2007, Pages 545-551

  Takahashi, Kenji ^a   Monzen, Satoru ^a   Eguchi Kasai, Kiyomi ^b   Abe, Yoshinao ^c   Kashiwakura, Ikuo ^a,c  

^a HIROSAKI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CYTOKINE; DOUBLE STRANDED DNA; THROMBOPOIETIN; HEAVY ION;

ARTICLE; CELL DAMAGE; CELL EXPANSION; DOUBLE STRANDED DNA BREAK; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; ION THERAPY; MEGAKARYOPOIESIS; PRIORITY JOURNAL; THROMBOCYTOPOIESIS; UMBILICAL CORD BLOOD; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE;

CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEAVY IONS; HEMATOPOIETIC STEM CELLS; HUMANS; RADIATION DOSAGE; THROMBOPOIESIS;

EID: 38449095812     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/rr1008.1     Document Type: Article

References (41)

1. T. Kanai, M. Endo, S. Minohara, N. Miyahara, H. Koyama-Ito, H. Tomura, N. Matsufuji, Y. Futami, A. Fukumura and K. Kawachi, Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44, 201-210 (1999).
2. U. Amaldi, Future trends in cancer therapy with particle accelerators. Z. Med. Phys. 14, 7-16 (2004).
3. D. Schulz-Ertner, O. Jäkel and W. Schlegel, Radiation therapy with charged particles. Semin. Radiat. Oncol. 16, 249-259 (2006).
4. A. Wojcik, E. Gregoire, I. Hayata, L. Roy, S. Sommer, G. Stephan and P. Voisin, Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents. Cytogenet. Genome Res. 104, 200-205 (2004).
5. F. Hérodin and M. Drouet, Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 33, 1071-1080 (2005).
6. F. A. Cucinotta and M. Durante, Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol. 7, 431-435 (2006).
7. G. Wagemaker, Heterogeneity of radiation sensitivity of hemopoietic stem cell subsets. Stem Cells 13 (Suppl. 1), 257-260 (1995).
8. M. Mori and C. Desaintes, Gene expression in response to ionizing radiation: an overview of molecular features in hematopoietic cells. J. Biol. Regul. Homeost. Agents 18, 363-371 (2004).
9. + progenitor cells corresponds to increased drug sensitivity and apoptotic response. Blood 100, 845-853 (2002).
10. N. Frickhofen, M. Korbling and T. M. Fliedner, Is blood a better source of allogeneic hematopoietic stem cells for use after radiation accidents? Bone Marrow Transplant. 17, 131-135 (1996).
11. Y. Wang, B. A. Schulte and D. Zhou, Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle 5, 35-38 (2006).
12. R. Neta, S. Douches and J. J. Oppenheim, Interleukin 1 is a radioprotector. J. Immunol. 136, 2483-2485 (1986).
13. M-A. Mouthon, A. Van der Meeren, M-H. Gaugler, T. P. Visser, C. Squiban, P. Gourmelon and G. Wagemaker, Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. Int. J. Radiat. Oncol. Biol. Phys. 43, 867-875 (1999).
14. M. Drouet, F. Mourcin, N. Grenier, V. Leroux, J. Denis, J-F. Mayol, P. Thullier, J-J. Lataillade and F. Herodin, Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood 103, 878-885 (2004).
15. V. K. Singh and V. S. Yadav, Role of cytokines and growth factors in radioprotection. Exp. Mol. Pathol. 78, 156-169 (2005).
16. S. Maddens, A. Charruyer, I. PIo, P. Dubreuil, S. Berger, B. Salles, G. Laurent and J-P. Jaffrézou, Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγI: implication in stem cell factor radioprotective effect. Blood 100, 1294-1301 (2002).
17. K. Maekawa, Overview of medical care for highly exposed victims in the Tokai mura accident. In The Medical Basis for Radiation Accident Preparedness (R. C. Ricks, M. E. Berger and F. M. O'Hara, Jr., Eds.), pp. 313-318. Parthenon, London, 2002.
18. S. R. Patel, J. H. Hartwig and J. H. Italiano, Jr., The biogenesis of platelets from megakaryocyte proplatelets. J. Clin. Invest. 115, 3348-3354 (2005).
19. G. Szalai, A. C. LaRue and D. K. Watson, Molecular mechanisms of megakaryopoiesis. Cell. Mol. Life Sci. 63, 2460-2476 (2006).
20. V. R. Deutsch and A. Tomer, Megakaryocyte development and platelet production. Br. J. Haematol. 134, 453-466 (2006).
21. P. J. Smith, C. W. Jackson, M. A. Whidden and C. C. Edwards, Effect of hypertransfusion on bone marrow regeneration in sublethally irradiated mice. II. Enhanced recovery of megakaryocytes and platelets. Blood 56, 58-63 (1980).
22. S. Ebbe, E. Phalen, G. Threatte and C. Adrados, Megakaryocytopoiesis in irradiated, splenectomized mice. Exp. Hematol. 9, 1020-1027 (1981).
23. S. Ebbe, Regulation of murine megakaryocyte size and ploidy by non-platelet-dependent mechanisms in radiation-induced megakaryocytopenia. Radiat. Res. 127, 278-284 (1991).
24. I. Kashiwakura, M. Kuwabara, O. Inanami, M. Murakami, Y. Hayase, T. A. Takahashi and Y. Takagi, Radiation sensitivity of megakaryocyte colony-forming cells in human placental and umbilical cord blood. Radiat. Res. 153, 144-152 (2000).
25. W. K. Hofmann, O. G. Ottmann and D. Hoelzer, Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies? Leukemia 13, 14-18 (1999).
26. G. D. Demetri, Targeted approaches for the treatment of thrombocytopenia. Oncologist 6 (Suppl. 5), 15-23 (2001).
27. D. J. Kuter and C. G. Begley, Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100, 3457-3469 (2000).
28. J. M. Heal and N. Blumberg, Optimizing platelet transfusion therapy. Blood Rev. 18, 149-165 (2004).
29. J. Li, C. Yang, Y. Xia, A. Bertino, J. Glaspy, M. Roberts and D. J. Kuter, Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98, 3241-3248 (2001).
30. A. M. Maurer, Y. Liu, J. P. Caen and Z. C. Han, Ex vivo expansion of megakaryocyte cells. Int. J. Hematol. 71, 203-210 (2000).
31. S. J. Szilvassy, Haematopoietic stem and progenitor cell-targeted therapies for thrombocytopenia. Expert Opin. Biol. Ther. 6, 983-992 (2006).
32. + cell proliferation and differentiation. Stem Cells 17, 273-285 (1999).
33. J. M. Bertho, E. Mathieu, A. Lauby, J. Frick, C. Demarquay, P. Gourmelon, N. C. Gorin and D. Thierry, Feasibility and limits of bone marrow mononuclear cell expansion following irradiation. Int. J. Radiat. Biol. 80, 73-81 (2004).
34. I. Kashiwakura, O. Inanami, Y. Abe, K. Satoh, T. A. Takahashi and M. Kuwabara, Regeneration of megakaryocytopoiesis and thrombopoiesis in vitro from X-irradiated human hematopoietic stem cells. Radiat. Res. 166, 345-351 (2006).
35. T. Kanai, M. Endo, S, Minohara, N. Miyahara, H. Koyama-Ito, H. Tomura, N. Matsufuji, Y. Futami, A. Fukumura and K. Kawachi, Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44, 201-210 (1999).
36. 20Ne-ion beams. Radiat. Res. 154, 485-496 (2000).
37. L. Sun, P. Tan, C. Yap, W. Hwang, L. P. Koh, C. K. Lim and S. E. Aw, In vitro biological characteristics of human cord blood-derived megakaryocytes. Ann. Acad. Med. Singapore 33, 570-575 (2004).
38. + cells megakaryocytic progenitor cells from human placental and umbilical cord blood. Radiat. Res. 160, 210-216 (2003).
39. J-H. Park, E-J. Park, H-S. Lee, S. J. Kim, S-K. Hur, A. N. Imbalzano and J. Kwon, Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting 7-H2AX induction. EMBO J. 25, 3986-3997 (2006).
40. S. Monzen, T. Mori, K. Takahashi, Y. Abe, O. Inanami, M. Kuwabara and I. Kashiwakura, The effects of (-)-epigallocatechin-3-gallate on the proliferation and differentiation of human megakaryocytic progenitor cells. J. Radiat. Res. 47, 213-220 (2006).
41. + cells in the presence of SCF, FLT3 ligand, TPO and IL-3: potential application to autologous cell therapy in accidentally irradiated victims. Radiat. Res. 164, 1-9 (2005).