메뉴 건너뛰기




Volumn 50, Issue 5, 2009, Pages 385-393

Molecular mechanisms involved in adaptive responses to radiation, UV light, and Heat

Author keywords

Adaptive response; Heat; HSP; p53; Radiation; UV

Indexed keywords

ADAPTIVE RESPONSE; ENVIRONMENTAL CHANGE; ENVIRONMENTAL STRESS; HEAT; HSP; MOLECULAR MECHANISM; P53; SIGNAL TRANSDUCTION PATHWAYS; UV; UV-LIGHT;

EID: 71749097615     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.09048S     Document Type: Review
Times cited : (20)

References (55)
  • 1
    • 0022922823 scopus 로고
    • Evidence that the [3H] thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism
    • Wiencke, J. K., Afzal, V., Olivieri, G. and Wolff, S. (1986) Evidence that the [3H] thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism. Mutagenesis 1: 375-380.
    • (1986) Mutagenesis , vol.1 , pp. 375-380
    • Wiencke, J.K.1    Afzal, V.2    Olivieri, G.3    Wolff, S.4
  • 3
    • 0035131428 scopus 로고    scopus 로고
    • Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells
    • Takahashi, A. (2001) Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells. Int. J. Radiat. Biol. 77: 215-224.
    • (2001) Int. J. Radiat. Biol. , vol.77 , pp. 215-224
    • Takahashi, A.1
  • 4
    • 0027714692 scopus 로고
    • Low dose radiation-induced adaptive survival response in mouse spleen T-lymphocytes in vivo
    • Yoshida, N., Imada, H., Kunugita, N. and Norimura, T. (1993) Low dose radiation-induced adaptive survival response in mouse spleen T-lymphocytes in vivo. J. Radiat. Res. (Tokyo) 34: 269-276.
    • (1993) J. Radiat. Res. (Tokyo) , vol.34 , pp. 269-276
    • Yoshida, N.1    Imada, H.2    Kunugita, N.3    Norimura, T.4
  • 5
    • 0028879481 scopus 로고
    • On the reaction kinetics of the radioadaptive response in cultured mouse cells
    • Sasaki, M. S. (1995) On the reaction kinetics of the radioadaptive response in cultured mouse cells. Int. J. Radiat. Biol. 68: 281-291.
    • (1995) Int. J. Radiat. Biol. , vol.68 , pp. 281-291
    • Sasaki, M.S.1
  • 6
    • 33846203833 scopus 로고    scopus 로고
    • TP53 and TP53-related genes associated with protection from apoptosis in the radioadaptive response
    • Okazaki, R., Ootsuyama, A. and Norimura, T. (2007) TP53 and TP53-related genes associated with protection from apoptosis in the radioadaptive response. Radiat. Res. 167: 51-57.
    • (2007) Radiat. Res. , vol.167 , pp. 51-57
    • Okazaki, R.1    Ootsuyama, A.2    Norimura, T.3
  • 7
    • 34548714260 scopus 로고    scopus 로고
    • Nitric oxide radicals choreograph a radioadaptive response
    • Matsumoto, H., Takahashi, A. and Ohnishi, T. (2007) Nitric oxide radicals choreograph a radioadaptive response. Cancer Res. 67: 1-6.
    • (2007) Cancer Res. , vol.67 , pp. 1-6
    • Matsumoto, H.1    Takahashi, A.2    Ohnishi, T.3
  • 11
    • 0022834741 scopus 로고
    • Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation
    • Sanderson, B. J. and Morley, A. A. (1986) Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation. Mutat. Res. 164: 347-351.
    • (1986) Mutat. Res. , vol.164 , pp. 347-351
    • Sanderson, B.J.1    Morley, A.A.2
  • 12
    • 0023272666 scopus 로고
    • Characterization of the adaptive response to ionizing radiation induced by low doses of X rays to human lymphocytes
    • Shadley, J. D., Afzal, V. and Wolff, S. (1987) Characterization of the adaptive response to ionizing radiation induced by low doses of X rays to human lymphocytes. Radiat. Res. 111: 511-517.
    • (1987) Radiat. Res. , vol.111 , pp. 511-517
    • Shadley, J.D.1    Afzal, V.2    Wolff, S.3
  • 13
    • 1642499456 scopus 로고    scopus 로고
    • Increase in endogenous spleen colonies without recovery of blood cell counts in radioadaptive survival response in C57BL/6 mice
    • Yonezawa, M., Horie, K., Kondo, H. and Kubo, K. (2004) Increase in endogenous spleen colonies without recovery of blood cell counts in radioadaptive survival response in C57BL/6 mice. Radiat. Res. 161: 161-167.
    • (2004) Radiat. Res. , vol.161 , pp. 161-167
    • Yonezawa, M.1    Horie, K.2    Kondo, H.3    Kubo, K.4
  • 14
    • 0008779227 scopus 로고    scopus 로고
    • Two types of X-ray-induced radioresistance in mice: Presence of 4 dose ranges with distinct biological effects
    • Yonezawa, M., Misonoh, J. and Hosokawa, Y. (1996) Two types of X-ray-induced radioresistance in mice: presence of 4 dose ranges with distinct biological effects. Mutat. Res. 358: 237-243.
    • (1996) Mutat. Res. , vol.358 , pp. 237-243
    • Yonezawa, M.1    Misonoh, J.2    Hosokawa, Y.3
  • 15
    • 51649088216 scopus 로고    scopus 로고
    • Rapid myeloid recovery as a possible mechanism of whole-body radioadaptive response
    • Otsuka, K., Koana, T., Tomita, M., Ogata, H. and Tauchi, H.(2008) Rapid myeloid recovery as a possible mechanism of whole-body radioadaptive response. Radiat Res. 170: 307-315.
    • (2008) Radiat Res. , vol.170 , pp. 307-315
    • Otsuka, K.1    Koana, T.2    Tomita, M.3    Ogata, H.4    Tauchi, H.5
  • 16
    • 34347178672 scopus 로고
    • On the relationship between host-cell reactivation and UV-reactivation in UV-inactivated phages
    • Harm, W. (1963) On the relationship between host-cell reactivation and UV-reactivation in UV-inactivated phages. Z. Vererbungsl. 94: 67-79.
    • (1963) Z. Vererbungsl. , vol.94 , pp. 67-79
    • Harm, W.1
  • 17
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A., Lindsey-Boltz, L. A., Unsal-Kacmaz, K. and Linn, S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73:39-85.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 18
    • 0028117141 scopus 로고
    • Structure and function of DNA photolyase
    • Sancar, A. (1994) Structure and function of DNA photolyase. Biochemistry 33: 2-9.
    • (1994) Biochemistry , vol.33 , pp. 2-9
    • Sancar, A.1
  • 19
    • 0037115936 scopus 로고    scopus 로고
    • Subpathways of nucleotide excision repair and their regulation
    • Hanawalt, P. C. (2002) Subpathways of nucleotide excision repair and their regulation. Oncogene 21: 8949-8956.
    • (2002) Oncogene , vol.21 , pp. 8949-8956
    • Hanawalt, P.C.1
  • 20
    • 0034734382 scopus 로고    scopus 로고
    • DNA photolyases and cryptochromes
    • Deisenhofer, J. (2000) DNA photolyases and cryptochromes. Mutat. Res. 460: 143-149.
    • (2000) Mutat. Res. , vol.460 , pp. 143-149
    • Deisenhofer, J.1
  • 21
    • 0023227827 scopus 로고
    • Induction of phr gene expression by irradiation of ultraviolet light in Escherichia coli
    • Ihara, M., Yamamoto, K. and Ohnishi, T. (1987) Induction of phr gene expression by irradiation of ultraviolet light in Escherichia coli. Mol. Gen. Genet. 209: 200-202.
    • (1987) Mol. Gen. Genet. , vol.209 , pp. 200-202
    • Ihara, M.1    Yamamoto, K.2    Ohnishi, T.3
  • 22
    • 0023411075 scopus 로고
    • Induction of phr gene expression by pyrimidine dimers in Escherichia coli
    • Ihara, M., Yamamoto, K. and Ohnishi, T. (1987) Induction of phr gene expression by pyrimidine dimers in Escherichia coli. Photochem. Photobiol. 46: 359-361.
    • (1987) Photochem. Photobiol. , vol.46 , pp. 359-361
    • Ihara, M.1    Yamamoto, K.2    Ohnishi, T.3
  • 23
    • 0014480808 scopus 로고
    • A model for ultraviolet and photoreactivating light effects in Euglena
    • Hill, H. Z. and Alling, D. W. (1951) A model for ultraviolet and photoreactivating light effects in Euglena. Biophys. J. 9: 347-359.
    • (1951) Biophys. J. , vol.9 , pp. 347-359
    • Hill, H.Z.1    Alling, D.W.2
  • 24
    • 84981841389 scopus 로고
    • Ultraviolet inactivation and photoreactivation of chloroplast development in Euglena without cell death
    • Lyman, H., Epstein, H. T. and Schiff, J. A. (1959) Ultraviolet inactivation and photoreactivation of chloroplast development in Euglena without cell death. J. Protozool. 6: 264-265.
    • (1959) J. Protozool. , vol.6 , pp. 264-265
    • Lyman, H.1    Epstein, H.T.2    Schiff, J.A.3
  • 25
    • 0016613396 scopus 로고
    • Photoreactivating enzyme from Euglena and the control of its intracellular level
    • Diamond, J., Schiff J. A. and Kelner, A. (1975) Photoreactivating enzyme from Euglena and the control of its intracellular level. Arch. Biochem. Biophys. 167: 603-614.
    • (1975) Arch. Biochem. Biophys. , vol.167 , pp. 603-614
    • Diamond, J.1    Schiff, J.A.2    Kelner, A.3
  • 26
    • 33646577803 scopus 로고    scopus 로고
    • UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis
    • Takahashi, A., Shibata, N., Nishikawa, S., Ohnishi, K., Ishioka, N. and Ohnishi, T. (2006) UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis. Photochem. Photobiol. Sci. 5: 467-471.
    • (2006) Photochem. Photobiol. Sci. , vol.5 , pp. 467-471
    • Takahashi, A.1    Shibata, N.2    Nishikawa, S.3    Ohnishi, K.4    Ishioka, N.5    Ohnishi, T.6
  • 27
    • 24644510163 scopus 로고    scopus 로고
    • Photoreactivation in Paramecium tetraurelia under condition of various degree of ozone layer depletion
    • Takahashi, A., Kumatani, T., Usui, S., Tsujimura, R., Seki, T., Morimoto, K. and Ohnishi, T. (2005) Photoreactivation in Paramecium tetraurelia under condition of various degree of ozone layer depletion. Photochem. Photobiol. 81: 1010-1014.
    • (2005) Photochem. Photobiol. , vol.81 , pp. 1010-1014
    • Takahashi, A.1    Kumatani, T.2    Usui, S.3    Tsujimura, R.4    Seki, T.5    Morimoto, K.6    Ohnishi, T.7
  • 28
    • 0000110478 scopus 로고
    • Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture
    • Takahashi, A., Takeda, K. and Ohnishi, T. (1991) Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture. Plant Cell Phys. 32: 541-547.
    • (1991) Plant Cell Phys. , vol.32 , pp. 541-547
    • Takahashi, A.1    Takeda, K.2    Ohnishi, T.3
  • 29
    • 0027521994 scopus 로고
    • Melanin reduces ultraviolet-induced DNA damage formation and cell killing rate in cultured human melanoma cells
    • Kobayashi, N., Muramatsu, T., Yamashina, Y., Shirai, T., Ohnishi, T. and Mori, T. (1993) Melanin reduces ultraviolet-induced DNA damage formation and cell killing rate in cultured human melanoma cells. J. Invest. Dermatol. 101: 685-689.
    • (1993) J. Invest. Dermatol. , vol.101 , pp. 685-689
    • Kobayashi, N.1    Muramatsu, T.2    Yamashina, Y.3    Shirai, T.4    Ohnishi, T.5    Mori, T.6
  • 30
    • 0036759596 scopus 로고    scopus 로고
    • Evolution of UV-B regulation and protection in plants
    • Björn, L. O., Widell, S. and Wang, T. (2002) Evolution of UV-B regulation and protection in plants. Adv. Space Res. 30: 1557-1562.
    • (2002) Adv. Space Res. , vol.30 , pp. 1557-1562
    • Björn, L.O.1    Widell, S.2    Wang, T.3
  • 32
    • 51849110344 scopus 로고    scopus 로고
    • Dynamics of pigmentation induction by repeated ultraviolet exposures: Dose, dose interval and ultraviolet spectrum dependence
    • Miller, S. A., Coelho, S. G., Zmudzka, B. Z., Bushar, H. F., Yamaguchi, Y., Hearing, V. J. and Beer, J. Z. (2008) Dynamics of pigmentation induction by repeated ultraviolet exposures: dose, dose interval and ultraviolet spectrum dependence. Br. J. Dermatol. 159: 921-930.
    • (2008) Br. J. Dermatol. , vol.159 , pp. 921-930
    • Miller, S.A.1    Coelho, S.G.2    Zmudzka, B.Z.3    Bushar, H.F.4    Yamaguchi, Y.5    Hearing, V.J.6    Beer, J.Z.7
  • 34
    • 0020130877 scopus 로고
    • Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts
    • Li, G. C. and Werb, Z. (1982) Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. Proc. Natl. Acad. Sci. USA 79: 3218-3222.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3218-3222
    • Li, G.C.1    Werb, Z.2
  • 35
    • 0025210036 scopus 로고
    • Induction of H sp27 phosphorylation and thermoresistance in Chinese hamster cells by arsenite, cycloheximide, A23187, and EGTA
    • Crête, P. and Landry, J. (1990) Induction of H sp27 phosphorylation and thermoresistance in Chinese hamster cells by arsenite, cycloheximide, A23187, and EGTA. Radiat. Res. 121: 320-327.
    • (1990) Radiat. Res. , vol.121 , pp. 320-327
    • Crête, P.1    Landry, J.2
  • 36
    • 4644275791 scopus 로고    scopus 로고
    • Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status
    • Ohnishi, K., Takahashi, A., Yokota, S. and Ohnishi, T. (2004) Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status. Int. J. Radiat. Biol. 80: 607-614.
    • (2004) Int. J. Radiat. Biol. , vol.80 , pp. 607-614
    • Ohnishi, K.1    Takahashi, A.2    Yokota, S.3    Ohnishi, T.4
  • 38
    • 11244344381 scopus 로고    scopus 로고
    • p53: Traffic cop at the crossroads of DNA repair and recombination
    • Sengupta, S. and Harris, C. C. (2005) p53: Traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell Biol. 6: 44-55.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 44-55
    • Sengupta, S.1    Harris, C.C.2
  • 39
    • 34247842988 scopus 로고    scopus 로고
    • Photosensitized DNA damage and its protection via a novel mechanism
    • Hiraku, Y., Ito, K., Hirakawa, K. and Kawanishi, S. (2007) Photosensitized DNA damage and its protection via a novel mechanism. Photochem. Photobiol. 83: 205-212.
    • (2007) Photochem. Photobiol. , vol.83 , pp. 205-212
    • Hiraku, Y.1    Ito, K.2    Hirakawa, K.3    Kawanishi, S.4
  • 40
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane, D. P. (1992) Cancer. p53, guardian of the genome. Nature 358: 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 41
    • 33750803814 scopus 로고    scopus 로고
    • A new function for p53 ubiquitination
    • Hirano, Y. and Ronai, Z. (2006) A new function for p53 ubiquitination. Cell 127: 675-677.
    • (2006) Cell , vol.127 , pp. 675-677
    • Hirano, Y.1    Ronai, Z.2
  • 43
    • 0029079360 scopus 로고
    • Binding between wild-type p53 and Hsp72 accumulated after UV and γ-ray irradiation
    • Matsumoto, H., Wang, X. and Ohnishi, T. (1995) Binding between wild-type p53 and Hsp72 accumulated after UV and γ-ray irradiation. Cancer Lett. 92: 127-133.
    • (1995) Cancer Lett. , vol.92 , pp. 127-133
    • Matsumoto, H.1    Wang, X.2    Ohnishi, T.3
  • 45
    • 0030478313 scopus 로고    scopus 로고
    • Heat shock transcription factor, HSF, is activated by ultraviolet irradiation
    • Ohnishi, K., Matsumoto, H., Takahashi, A., Wang, X. and Ohnishi, T. (1996) Heat shock transcription factor, HSF, is activated by ultraviolet irradiation. Photochem. Photobiol. 64: 949-952.
    • (1996) Photochem. Photobiol. , vol.64 , pp. 949-952
    • Ohnishi, K.1    Matsumoto, H.2    Takahashi, A.3    Wang, X.4    Ohnishi, T.5
  • 46
    • 62649107111 scopus 로고    scopus 로고
    • A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning
    • Takahashi, A. and Ohnishi, T. (2009) A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning. Adv. Space Res. 43: 1185-1192.
    • (2009) Adv. Space Res. , vol.43 , pp. 1185-1192
    • Takahashi, A.1    Ohnishi, T.2
  • 47
    • 0027469281 scopus 로고
    • Regulation of the human Hsp70 promoter by p53
    • Agoff, S. N., Hou, J., Linzer, D. I. and Wu, B. (1993) Regulation of the human Hsp70 promoter by p53. Science 259: 84-87.
    • (1993) Science , vol.259 , pp. 84-87
    • Agoff, S.N.1    Hou, J.2    Linzer, D.I.3    Wu, B.4
  • 48
    • 0027273957 scopus 로고
    • Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of Hsp70 mRNA, Hsc70 and Hsp72 and with an increased capacity to proliferate
    • Nogami, M., Huang, J. T., James, S. J., Lubinski, J. M., Nakamura, L. T. and Makinodan, T. (1993) Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of Hsp70 mRNA, Hsc70 and Hsp72 and with an increased capacity to proliferate. Int. J. Radiat. Biol. 63: 775-783.
    • (1993) Int. J. Radiat. Biol. , vol.63 , pp. 775-783
    • Nogami, M.1    Huang, J.T.2    James, S.J.3    Lubinski, J.M.4    Nakamura, L.T.5    Makinodan, T.6
  • 49
    • 0028022542 scopus 로고
    • T cells are the cellular target of the proliferation-augmenting effect of chronic low-dose ionizing radiation in mice
    • Nogami, M., Huang, J. T., Nakamura, L. T. and Makinodan, T. (1994) T cells are the cellular target of the proliferation-augmenting effect of chronic low-dose ionizing radiation in mice. Radiat. Res. 139: 47-52.
    • (1994) Radiat. Res. , vol.139 , pp. 47-52
    • Nogami, M.1    Huang, J.T.2    Nakamura, L.T.3    Makinodan, T.4
  • 50
    • 0031808112 scopus 로고    scopus 로고
    • Low-dose irradiation induces expression of heat shock protein 70 mRNA and thermo- and radio-resistance in myeloid leukemia cell line
    • Ibuki, Y., Hayashi, A., Suzuki, A. and Goto, R. (1998) Low-dose irradiation induces expression of heat shock protein 70 mRNA and thermo- and radio-resistance in myeloid leukemia cell line. Biol. Pharm. Bull. 21: 434-439.
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 434-439
    • Ibuki, Y.1    Hayashi, A.2    Suzuki, A.3    Goto, R.4
  • 51
    • 0031908233 scopus 로고    scopus 로고
    • Effect of low-dose preirradiation on induction of the Hsp70B-LacZ fusion gene in human cells treated with heat shock
    • Suzuki, K., Kodama, S. and Watanabe, M. (1998) Effect of low-dose preirradiation on induction of the Hsp70B-LacZ fusion gene in human cells treated with heat shock. Radiat. Res. 149: 195-201.
    • (1998) Radiat. Res. , vol.149 , pp. 195-201
    • Suzuki, K.1    Kodama, S.2    Watanabe, M.3
  • 52
    • 33745961862 scopus 로고    scopus 로고
    • The p53-Bcl-2 connection
    • Hemann, M. T. and Lowe, S. W. (2006) The p53-Bcl-2 connection. Cell Death Differ. 13: 1256-1259.
    • (2006) Cell Death Differ , vol.13 , pp. 1256-1259
    • Hemann, M.T.1    Lowe, S.W.2
  • 53
    • 0034193202 scopus 로고    scopus 로고
    • Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma
    • Ota, I., Ohnishi, K., Takahashi, A., Yane, K., Kanata, H., Miyahara, H., Ohnishi, T. and Hosoi, H. (2000) Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 47: 495-501.
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.47 , pp. 495-501
    • Ota, I.1    Ohnishi, K.2    Takahashi, A.3    Yane, K.4    Kanata, H.5    Miyahara, H.6    Ohnishi, T.7    Hosoi, H.8
  • 54
    • 0033002710 scopus 로고    scopus 로고
    • Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone
    • Ohnishi, T., Ohnishi, K., Wang, X., Takahashi, A. and Okaichi, K. (1999) Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone. Radiat. Res. 151: 498-500.
    • (1999) Radiat. Res. , vol.151 , pp. 498-500
    • Ohnishi, T.1    Ohnishi, K.2    Wang, X.3    Takahashi, A.4    Okaichi, K.5
  • 55
    • 0036022408 scopus 로고    scopus 로고
    • Transfection of mutant p53 gene depresses X-ray- and CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck
    • Ohnishi, K., Ota, I., Takahashi, A., Yane, K., Matsumoto, H. and Ohnishi, T. (2002) Transfection of mutant p53 gene depresses X-ray- and CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck. Apoptosis 7: 367-372.
    • (2002) Apoptosis , vol.7 , pp. 367-372
    • Ohnishi, K.1    Ota, I.2    Takahashi, A.3    Yane, K.4    Matsumoto, H.5    Ohnishi, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.