In vivo MRI reveals the dynamics of pathological changes in the brains of cathepsin D-deficient mice and correlates changes in manganese-enhanced MRI with microglial activation

Magnetic Resonance Imaging

Volumn 25, Issue 7, 2007, Pages 1024-1031

  Haapanen, Aleksi ^a   Ramadan, Usama Abo ^b   Autti, Taina ^b   Joensuu, Raimo ^c   Tyynelä, Jaana ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Batten disease; Brain; Cathepsin D; Magnetic resonance imaging; Mouse

Indexed keywords

CATHEPSIN D; MANGANESE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN DEGENERATION; CATHEPSIN D DEFICIENCY; CELL ACTIVATION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; DISEASE COURSE; ENZYME DEFICIENCY; HISTOLOGY; IN VIVO STUDY; MICROGLIA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; THALAMUS;

MUS; OVIS ARIES;

ANIMALS; BRAIN; CATHEPSINS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; MAGNETIC RESONANCE IMAGING; MANGANESE; MICE; MICROGLIA;

EID: 34547842027     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2007.03.012     Document Type: Article

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