p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function

Cancer Letters

Volumn 286, Issue 2, 2009, Pages 240-249

  Liu, Shicheng ^a   Yamauchi, Hitoshi ^a  

^a Nipro Corporation   (Japan)

Author keywords

G1 arrest; Hinokitiol; Human malignant melanoma cells

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; SMALL INTERFERING RNA; THREONINE; THUJAPLICIN; UBIQUITIN PROTEIN LIGASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G1 PHASE; HUMANS; IMMUNOBLOTTING; MELANOMA; MONOTERPENES; PHOSPHORYLATION; PROTEIN BINDING; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; S PHASE; S-PHASE KINASE-ASSOCIATED PROTEINS; TROPOLONE;

EID: 71549119163     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.05.038     Document Type: Article

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