Transforming growth factor-β type I receptor/ALK5 contributes to doxazosin-induced apoptosis in H9C2 cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 6, 2009, Pages 561-567

  Yang, Yi Fan ^a,b   Wu, Chau Chung ^a,b   Chen, Wen Pin ^a   Su, Ming Jai ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

ALK5; Apoptosis; Doxazosin; P38 MAPK; T RI; TGF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CASPASE 3; DOXAZOSIN; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEART MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXAZOSIN; MYOBLASTS, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 71349088555     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0449-1     Document Type: Article

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