Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin

Journal of Biomedical Science

Volumn 15, Issue 4, 2008, Pages 519-528

  Lee, An Sheng ^a   Chen, Wen Pin ^a   Su, Ming Jai ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Alpha blockers; Arrhythmia; Electrophysiology; Langendorff perfused heart

Indexed keywords

BUNAZOSIN; DOXAZOSIN; SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR JUNCTION ARRHYTHMIA; CALCIUM CURRENT; CONTROLLED STUDY; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; HEART MUSCLE; HEART PERFUSION; HEART RATE; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SINUS RHYTHM; SODIUM CURRENT;

ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIAC ELECTROPHYSIOLOGY; DOXAZOSIN; DRUG TOXICITY; HEART; ION CHANNELS; QUINAZOLINES; RATS;

RATTUS;

EID: 44949212700     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/s11373-008-9249-8     Document Type: Article

References (33)

1. Kaplan NM (1988) Effects of antihypertensive therapy on cardiac function. Am Heart J 116(1 Pt 1):260-264
2. Furuya S, Kumamoto Y, Yokoyama E, Tsukamoto T, Izumi T, Abiko Y (1982) Alpha-adrenergic activity and urethral pressure in prostatic zone in benign prostatic hypertrophy. J Urol 128(4):836-839
3. Courtney CH, McCance DR, Atkinson AB, Bassett J, Ennis CN, Sheridan B, Bell PM (2003) Effect of the alpha-adrenergic blocker, doxazosin, on endothelial function and insulin action. Metabolism 52(9):1147-1152
4. Wilson TA, Foxall TL, Nicolosi RJ (2003) Doxazosin, an alpha-1 antagonist, prevents further progression of the advanced atherosclerotic lesion in hypercholesterolemic hamsters. Metabolism 52(10):1240-1245
5. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group (2000) JAMA 283(15):1967-1975
6. Lee AS, Su MJ (2007) Comparison of the cardiac effects between quinazoline-based alpha(1)-adrenoceptor antagonists on occlusion-reperfusion injury. J Biomed Sci 15(2):239-249
7. Marban E (2002) Cardiac channelopathies. Nature 415(6868):213-218
8. Schram G, Pourrier M, Melnyk P, Nattel S (2002) Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 90(9):939-950
9. Priori SG, Napolitano C, Schwartz PJ (1993) Cardiac receptor activation and arrhythmogenesis. Eur Heart J 14 Suppl E:20-26
10. Shannon R, Chaudhry M (2006) Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Am Heart J 152(5):842-850
11. Hamlin RL, Cruze CA, Mittelstadt SW, Kijtawornrat A, Keene BW, Roche BM, Nakayama T, Nakayama H, Hamlin DM, Arnold T (2004) Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc. J Pharmacol Toxicol Methods 49(1):15-23
12. Mitchell GF, Jeron A, Koren G (1998) Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol 274(3 Pt 2):H747-H751
13. Chen WP, Su MJ, Hung LM (2007) In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. Eur J Pharmacol 554(2-3):196-204
14. Lee AS, Wu TS, Su MJ (2008) Pharmacological profile of the new inotropic agent AT-11. Eur J Pharmacol 580(1-2):224-230
15. Josephson IR, Sanchez-Chapula J, Brown AM (1984) Early outward current in rat single ventricular cells. Circ Res 54(2):157-162
16. Salama G, London B (2007) Mouse models of long QT syndrome. J Physiol 578(Pt 1):43-53
17. James TN (2002) Structure and function of the sinus node, AV node and His bundle of the human heart: part I-structure. Prog Cardiovasc Dis 45(3):235-267
18. James TN (2003) Structure and function of the sinus node, AV node and his bundle of the human heart: part II-function. Prog Cardiovasc Dis 45(4):327-360
19. Akhtar M, Jazayeri MR, Sra J, Blanck Z, Deshpande S, Dhala A (1993) Atrioventricular nodal reentry. Clinical, electrophysiological, and therapeutic considerations. Circulation 88(1):282-295
20. McGuire MA, Janse MJ (1995) New insights on anatomical location of components of the reentrant circuit and ablation therapy for atrioventricular junctional reentrant tachycardia. Curr Opin Cardiol 10(1):3-8
21. Sung RJ, Lauer MR, Chun H (1994) Atrioventricular node reentry: current concepts and new perspectives. Pacing Clin Electrophysiol 17(8):1413-1430
22. Wit AL, Cranefield PF (1974) Effect of verapamil on the sinoatrial and atrioventricular nodes of the rabbit and the mechanism by which it arrests reentrant atrioventricular nodal tachycardia. Circ Res 35(3):413-425
23. Whalley DW, Wendt DJ, Grant AO (1995) Basic concepts in cellular cardiac electrophysiology: part I: ion channels, membrane currents, and the action potential. Pacing Clin Electrophysiol 18(8):1556-1574
24. Medkour D, Becker AE, Khalife K, Billette J (1998) Anatomic and functional characteristics of a slow posterior AV nodal pathway: role in dual-pathway physiology and reentry. Circulation 98(2):164-174
25. Denes P, Wu D, Dhingra RC, Chuquimia R, Rosen KM (1973) Demonstration of dual A-V nodal pathways in patients with paroxysmal supraventricular tachycardia. Circulation 48(3):549-555
26. Irisawa H, Brown HF, Giles W (1993) Cardiac pacemaking in the sinoatrial node. Physiol Rev 73(1):197-227
27. Guo J, Mitsuiye T, Noma A (1997) The sustained inward current in sino-atrial node cells of guinea-pig heart. Pflugers Arch 433(4):390-396
28. + currents in pacemaker activity in the sinoatrial node. Am J Physiol 272(6 Pt 2):H2793-H2806
29. Hondeghem LM, Katzung BG (1977) Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472(3-4):373-398
30. Brown AM, Lee KS, Powell T (1981) Sodium current in single rat heart muscle cells. J Physiol 318:479-500
31. Follmer CH, Aomine M, Yeh JZ, Singer DH (1987) Amiodarone-induced block of sodium current in isolated cardiac cells. J Pharmacol Exp Ther 243(1):187-194
32. + currents in isolated adult rat ventricular myocytes. J Gen Physiol 97(5):973-1011
33. Frick MH, Halttunen P, Himanen P, Huttunen M, Porsti P, Pitkajarvi T, Poyhonen L, Pyykonen ML, Reinikainen P, Salmela P et al (1986) A long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate essential hypertension. Br J Clin Pharmacol 21 Suppl 1:55S-S62