Chapter 5 Drosophila Myc

Advances in Cancer Research

Volumn 103, Issue C, 2009, Pages 111-144

  Gallant, Peter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

basic region helix loop helix leucine zipper; BHLHZ; central nervous system; CNS; Decapentaplegic (a Drosophila melanogaster TGF homolog); diminutive (=Drosophila melanogaster Myc gene); dm; Dpp; FLP recombinase target; FRT; ganglion mother cell; germline stem cell; GMC; GSC; H3K4me3; Hedgehog; Hh; histone H3, trimethylated on lysine 4; Inr; Insulin receptor; MB1 2 3; Myc box 1 2 3; SID; Sin3 interaction domain; target of rapamycin; TOR; UAS; upstream activating sequence; Wg; Wingless (a Drosophila melanogaster Wnt homolog); ZNC; zone of nonproliferating cells

Indexed keywords

HELICASE; MAX PROTEIN; MYC PROTEIN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; DROSOPHILA PROTEIN; MAX PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; DNA REPLICATION; DNA SYNTHESIS; DROSOPHILA; EMBRYO DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; STEM CELL; VERTEBRATE; ANIMAL; DROSOPHILA MELANOGASTER; FLY; GENE REGULATORY NETWORK; GENETICS; METABOLISM; ONCOGENE MYC; PHYSIOLOGY;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; DIPTERA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE REGULATORY NETWORKS; GENES, MYC; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTORS;

EID: 71149115489     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-230X(09)03005-X     Document Type: Review

References (129)

1. Adhikary S., and Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6 (2005) 635-645
2. Amati B., Dalton S., Brooks M.W., Littlewood T.D., Evan G.I., and Land H. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359 (1992) 423-426
3. Amati B., Brooks M.W., Levy N., Littlewood T.D., Evan G.I., and Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72 (1993) 233-245
4. Amati B., Littlewood T.D., Evan G.I., and Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 12 (1993) 5083-5087
5. Arabi A., Wu S., Ridderstrale K., Bierhoff H., Shiue C., Fatyol K., Fahlen S., Hydbring P., Soderberg O., Grummt I., Larsson L.G., and Wright A.P. c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat. Cell Biol. 7 (2005) 303-310
6. Ashburner M., Golic K.G., and Hawley R.S. Drosophila: A Laboratory Handbook (2005), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
7. Austen M., Cerni C., Luscherfirzlaff J.M., and Luscher B. Yy1 can inhibit c-myc function through a mechanism requiring DNA binding of yy1 but neither its transactivation domain nor direct interaction with c-myc. Oncogene 17 (1998) 511-520
8. Bastock R., and St Johnston D. Drosophila oogenesis. Curr. Biol. 18 (2008) R1082-R1087
9. Bellosta P., Hulf T., Diop S.B., Usseglio F., Pradel J., Aragnol D., and Gallant P. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proc. Natl. Acad. Sci. USA 102 (2005) 11799-11804
10. Benassayag C., Montero L., Colombie N., Gallant P., Cribbs D., and Morello D. Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 25 (2005) 9897-9909
11. Berry D.L., and Baehrecke E.H. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 131 (2007) 1137-1148
12. Betschinger J., Mechtler K., and Knoblich J.A. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124 (2006) 1241
13. Blanco E., Pignatelli M., Beltran S., Punset A., Perez-Lluch S., Serras F., Guigo R., and Corominas M. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biol. 9 (2008) R134
14. Boutros M., Kiger A.A., Armknecht S., Kerr K., Hild M., Koch B., Haas S.A., Consortium H.F.A., Paro R., and Perrimon N. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303 (2004) 832-835
15. Brand A.H., Manoukian A.S., and Perrimon N. Ectopic expression in Drosophila. (Review). Methods Cell Biol. 44 (1994) 635-654
16. Bridges C.B. Drosophila melanogaster: legend for symbols, mutants, valuations. Drosoph. Inf. Serv. 3 (1935) 5-19
17. Britton J.S., Lockwood W.K., Li L., Cohen S.M., and Edgar B.A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2 (2002) 239-249
18. Byrd K.N., and Shearn A. ASH1, a Drosophila Trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Proc. Natl. Acad. Sci. USA 100 (2003) 11535-11540
19. Cheng S.W., Davies K.P., Yung E., Beltran R.J., Yu J., and Kalpana G.V. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nat. Genet. 22 (1999) 102-105
20. Cole M.D., and Cowling V.H. Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat. Rev. Mol. Cell Biol. 9 (2008) 810-815
21. Cowling V.H., and Cole M.D. Mechanism of transcriptional activation by the Myc oncoproteins. Semin. Cancer Biol. 16 (2006) 242
22. In: Dahmann C. (Ed). Drosophila: Methods and Protocols (2008), Humana Press, Totowa
23. Dang C.V., O'Donnell K.A., Zeller K.I., Nguyen T., Osthus R.C., and Li F. The c-Myc target gene network. Semin. Cancer Biol. 16 (2006) 253
24. de la Cova C., Abril M., Bellosta P., Gallant P., and Johnston L.A. Drosophila myc regulates organ size by inducing cell competition. Cell 117 (2004) 107-116
25. Demontis F., and Perrimon N. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development 136 (2009) 983-993
26. Dominguez-Sola D., Ying C.Y., Grandori C., Ruggiero L., Chen B., Li M., Galloway D.A., Gu W., Gautier J., and Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature 448 (2007) 445-451
27. Duman-Scheel M., Johnston L.A., and Du W. Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc. Natl. Acad. Sci. USA 101 (2004) 3857-3862
28. Eilers M., and Eisenman R.N. Myc's broad reach. Genes Dev. 22 (2008) 2755-2766
29. Etard C., Gradl D., Kunz M., Eilers M., and Wedlich D. Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1. Mech. Dev. 122 (2005) 545-556
30. Facchini L.M., Chen S.J., Marhin W.W., Lear J.N., and Penn L.Z. The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-Myc P2 minimal promoter. Mol. Cell. Biol. 17 (1997) 100-114
31. Fan Y., and Bergmann A. Apoptosis-induced compensatory proliferation. The cell is dead. Long live the cell!. Trends Cell Biol. 18 (2008) 467-473
32. Frei C., Galloni M., Hafen E., and Edgar B.A. The Drosophila mitochondrial ribosomal protein mRpL12 is required for cyclin D/Cdk4-driven growth. EMBO J. 24 (2005) 623-634
33. Fuller M.T., and Spradling A.C. Male and female Drosophila germline stem cells: two versions of immortality. Science 316 (2007) 402-404
34. Gallant P. Myc/Max/Mad in invertebrates-the evolution of the Max network. Curr. Top. Microbiol. Immunol. 302 (2006) 237-254
35. Gallant P. Control of transcription by Pontin and Reptin. Trends Cell Biol. 17 (2007) 187
36. Gallant P., Shiio Y., Cheng P.F., Parkhurst S.M., and Eisenman R.N. Myc and Max homologs in Drosophila. Science 274 (1996) 1523-1527
37. Galletti M., Riccardo S., Parisi F., Lora C., Saqcena M.K., Rivas L., Wong B., Serra A., Serras F., Grifoni D., Pelicci P., Jiang J., et al. Identification of domains responsible for ubiquitin-dependent degradation of dmyc by glycogen synthase kinase 3β and casein kinase 1 kinases. Mol. Cell. Biol. 29 (2009) 3424-3434
38. Garoia F., Grifoni D., Trotta V., Guerra D., Pezzoli M.C., and Cavicchi S. The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster. Mech. Dev. 122 (2005) 175-187
39. Gomez-Roman N., Grandori C., Eisenman R.N., and White R.J. Direct activation of RNA polymerase III transcription by c-Myc. Nature 421 (2003) 290-294
40. Goodliffe J.M., Wieschaus E., and Cole M.D. Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila. Genes Dev. 19 (2005) 2941-2946
41. Goodliffe J.M., Cole M.D., and Wieschaus E. Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. BMC Mol. Biol. 8 (2007) 40
42. Grandori C., Mac J., Siebelt F., Ayer D.E., and Eisenman R.N. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. EMBO J. 15 (1996) 4344-4357
43. Grandori C., Gomez-Roman N., Felton-Edkins Z.A., Ngouenet C., Galloway D.A., Eisenman R.N., and White R.J. c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat. Cell Biol. 7 (2005) 311-318
44. Greasley P.J., Bonnard C., and Amati B. Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis. Nucleic Acids Res. 28 (2000) 446-453
45. Greenspan R.J. Fly pushing-the theory and practice of Drosophila genetics (2004), Cold Spring Harbor Laboratory Press, Cold Spring Harbor
46. Grewal S.S., Li L., Orian A., Eisenman R.N., and Edgar B.A. Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat. Cell Biol. 7 (2005) 295-302
47. Guccione E., Martinato F., Finocchiaro G., Luzi L., Tizzoni L., Dall'Olio V., Zardo G., Nervi C., Bernard L., and Amati B. Myc-binding-site recognition in the human genome is determined by chromatin context. Nat. Cell Biol. 8 (2006) 764-770
48. Hennig K.M., and Neufeld T.P. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis 34 (2002) 107-110
49. Herranz H., Perez L., Martin F.A., and Milan M. A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing. EMBO J. 27 (2008) 1633-1645
50. Huang H., and He X. Wnt/β-catenin signaling: new (and old) players and new insights. Curr. Opin. Cell Biol. 20 (2008) 119-125
51. Hulf T., Bellosta P., Furrer M., Steiger D., Svensson D., Barbour A., and Gallant P. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Mol. Cell. Biol. 25 (2005) 3401-3410
52. Hurlin P.J., Zhou Z.Q., Toyo-oka K., Ota S., Walker W.L., Hirotsune S., and Wynshaw-Boris A. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 22 (2003) 4584-4596
53. Iritani B.M., and Eisenman R.N. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc. Natl. Acad. Sci. USA 96 (1999) 13180-13185
54. Jacobs J.J.L., Scheijen B., Voncken J.-W., Kieboom K., Berns A., and van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13 (1999) 2678-2690
55. Jaklevic B., Uyetake L., Lemstra W., Chang J., Leary W., Edwards A., Vidwans S., Sibon O., and Tin Su T. Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila. Genetics 174 (2006) 1963-1972
56. Jiao R., Daube M., Duan H., Zou Y., Frei E., and Noll M. Headless flies generated by developmental pathway interference. Development 128 (2001) 3307-3319
57. Jin Z., Kirilly D., Weng C., Kawase E., Song X., Smith S., Schwartz J., and Xie T. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell 2 (2008) 39-49
58. Johnston L.A., Prober D.A., Edgar B.A., Eisenman R.N., and Gallant P. Drosophila Myc regulates cellular growth during development. Cell 98 (1999) 779-790
59. King R.C. Ovarian development in Drosophila melanogaster (1970), Academic Press, New York and London
60. King R.C., and Vanoucek E.G. Oogenesis in adult Drosophila melanogaster X. Studies on the behaviour of the follicle cells. Growth 24 (1960) 333-338
61. Kretzner L., Blackwood E.M., and Eisenman R.N. Myc and Max proteins possess distinct transcriptional activities. Nature 359 (1992) 426-429
62. Lambertsson A. The minute genes in Drosophila and their molecular functions. Adv. Genet. 38 (1998) 69-134
63. Lee N., Erdjument-Bromage H., Tempst P., Jones R.S., and Zhang Y. The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol. Cell. Biol. 29 (2009) 1401-1410
64. Li W., and Baker N.E. Engulfment is required for cell competition. Cell 129 (2007) 1215
65. Liu J., and Levens D. Making myc. Curr. Top. Microbiol. Immunol. 302 (2006) 1-32
66. Liu J., He L., Collins I., Ge H., Libutti D., Li J., Egly J.-M., and Levens D. The FBP interacting repressor targets TFIIH to inhibit activated transcription. Mol. Cell 5 (2000) 331-341
67. Loo L.W., Secombe J., Little J.T., Carlos L.S., Yost C., Cheng P.F., Flynn E.M., Edgar B.A., and Eisenman R.N. The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol. Cell. Biol. 25 (2005) 7078-7091
68. Luscher-Firzlaff J., Gawlista I., Vervoorts J., Kapelle K., Braunschweig T., Walsemann G., Rodgarkia-Schamberger C., Schuchlautz H., Dreschers S., Kremmer E., Lilischkis R., Cerni C., et al. The human Trithorax protein hASH2 functions as an oncoprotein. Cancer Res. 68 (2008) 749-758
69. Maines J.Z., Stevens L.M., Tong X., and Stein D. Drosophila dMyc is required for ovary cell growth and endoreplication. Development 131 (2004) 775-786
70. Mao D.Y., Watson J.D., Yan P.S., Barsyte-Lovejoy D., Khosravi F., Wong W.W., Farnham P.J., Huang T.H., and Penn L.Z. Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr. Biol. 13 (2003) 882-886
71. Meyer N., and Penn L.Z. Reflecting on 25 years with MYC. Nat. Rev. Cancer 8 (2008) 976-990
72. Mitchell N., Cranna N., Richardson H., and Quinn L. The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila. Development 135 (2008) 2707-2716
73. Moberg K.H., Mukherjee A., Veraksa A., Artavanis-Tsakonas S., and Hariharan I.K. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr. Biol. 14 (2004) 965-974
74. Montero L., Müller N., and Gallant P. Induction of apoptosis by Drosophila Myc. Genesis 46 (2008) 104-111
75. Morata G., and Ripoll P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42 (1975) 211-221
76. Moreno E. Is cell competition relevant to cancer?. Nat. Rev. Cancer 8 (2008) 141
77. Moreno E., and Basler K. dMyc transforms cells into super-competitors. Cell 117 (2004) 117-129
78. Moreno E., Basler K., and Morata G. Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416 (2002) 755-759
79. Muller D., Kugler S.J., Preiss A., Maier D., and Nagel A.C. Genetic modifier screens on hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. Genetics 171 (2005) 1137-1152
80. Neumuller R.A., Betschinger J., Fischer A., Bushati N., Poernbacher I., Mechtler K., Cohen S.M., and Knoblich J.A. Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature 454 (2008) 241-245
81. Nilsson J.A., Maclean K.H., Keller U.B., Pendeville H., Baudino T.A., and Cleveland J.L. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Mol. Cell. Biol. 24 (2004) 1560-1569
82. Norga K.K., Gurganus M.C., Dilda C.L., Yamamoto A., Lyman R.F., Patel P.H., Rubin G.M., Hoskins R.A., Mackay T.F., and Bellen H.J. Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr. Biol. 13 (2003) 1388-1397
83. Orian A., Van Steensel B., Delrow J., Bussemaker H.J., Li L., Sawado T., Williams E., Loo L.W., Cowley S.M., Yost C., Pierce S., Edgar B.A., et al. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev. 17 (2003) 1101-1114
84. Orian A., Delrow J.J., Rosales Nieves A.E., Abed M., Metzger D., Paroush Z.e., Eisenman R.N., and Parkhurst S.M. A Myc Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc. Natl. Acad. Sci. USA 104 (2007) 15771-15776
85. Parker J. Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16 (2006) 2058-2065
86. Perrin L., Benassayag C., Morello D., Pradel J., and Montagne J. Modulo is a target of Myc selectively required for growth of proliferative cells in Drosophila. Mech. Dev. 120 (2003) 645
87. Peyrefitte S., Kahn D., and Haenlin M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Mech. Dev. 104 (2001) 99-104
88. Pierce S.B., Yost C., Britton J.S., Loo L.W., Flynn E.M., Edgar B.A., and Eisenman R.N. dMyc is required for larval growth and endoreplication in Drosophila. Development 131 (2004) 2317-2327
89. Pierce S.B., Yost C., Anderson S.A.R., Flynn E.M., Delrow J., and Eisenman R.N. Drosophila growth and development in the absence of dMyc and dMnt. Dev. Biol. 315 (2008) 303
90. Pignoni F., and Zipursky S.L. Induction of Drosophila eye development by decapentaplegic. Development 124 (1997) 271-278
91. Pirity M., Blanck J.K., and Schreiber-Agus N. Lessons learned from Myc/Max/Mad knockout mice. Curr. Top. Microbiol. Immunol. 302 (2006) 205-234
92. Prober D.A., and Edgar B.A. Ras1 promotes cellular growth in the Drosophila wing. Cell 100 (2000) 435-446
93. Prober D.A., and Edgar B.A. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 16 (2002) 2286-2299
94. Quinn L.M., Dickins R.A., Coombe M., Hime G.R., Bowtell D.D., and Richardson H. Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation. Development 131 (2004) 1411-1423
95. Reddy B.V.V.G., and Irvine K.D. The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development 135 (2008) 2827-2838
96. Rhiner C., Diaz B., Portela M., Poyatos J.F., Fernandez-Ruiz I., Lopez-Gay J.M., Gerlitz O., and Moreno E. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development 136 (2009) 995-1006
97. Sandmann T., Girardot C., Brehme M., Tongprasit W., Stolc V., and Furlong E.E.M. A core transcriptional network for early mesoderm development in Drosophila melanogaster. Genes Dev. 21 (2007) 436-449
98. Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex. Science 307 (2005) 1098-1101
99. Schreiber-Agus N., Stein D., Chen K., Goltz J.S., Stevens L., and DePinho R.A. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc. Natl. Acad. Sci. USA 94 (1997) 1235-1240
100. Schuettengruber B., Chourrout D., Vervoort M., Leblanc B., and Cavalli G. Genome regulation by Polycomb and Trithorax proteins. Cell 128 (2007) 735-745
101. Schuhmacher M., Staege M.S., Pajic A., Polack A., Weidle U.H., Bornkamm G.W., Eick D., and Kohlhuber F. Control of cell growth by c-Myc in the absence of cell division. Curr. Biol. 9 (1999) 1255-1258
102. Schulein C., and Eilers M. An unsteady scaffold for Myc. EMBO J. 28 (2009) 453-454
103. Schwamborn J.C., Berezikov E., and Knoblich J.A. The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell 136 (2009) 913-925
104. Schwinkendorf D., and Gallant P. The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo. Gene 436 (2009) 90-100
105. Scott R.C., Schuldiner O., and Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004) 167-178
106. Sears R.C. The life cycle of C-myc: from synthesis to degradation. Cell Cycle 3 (2004) 1133-1137
107. Secombe J., Li L., Carlos L., and Eisenman R.N. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 21 (2007) 537-551
108. Senoo-Matsuda N., and Johnston L.A. Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc. Proc. Natl. Acad. Sci. USA 104 (2007) 18543-18548
109. Shcherbata H.R., Althauser C., Findley S.D., and Ruohola-Baker H. The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development 131 (2004) 3169-3181
110. Shrivastava A., Saleque S., Kalpana G.V., Artandi S., Goff S.P., and Calame K. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262 (1993) 1889-1892
111. Simpson P., and Morata G. Differential mitotic rates and patterns of growth in compartments in the Drosophila wing. Dev. Biol. 85 (1981) 299-308
112. Spencer C.A., and Groudine M. Control of c-myc regulation in normal and neoplastic cells. (Review). Adv. Cancer Res. 56 (1991) 1-48
113. Steiger D., Furrer M., Schwinkendorf D., and Gallant P. Max-independent functions of Myc in Drosophila. Nat. Genet. 40 (2008) 1084-1091
114. Steller H. Regulation of apoptosis in Drosophila. Cell Death Differ. 15 (2008) 1132-1138
115. Tadros W., Goldman A.L., Babak T., Menzies F., Vardy L., Orr-Weaver T., Hughes T.R., Westwood J.T., Smibert C.A., and Lipshitz H.D. SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev. Cell 12 (2007) 143-155
116. Tapon N., Ito N., Dickson B.J., Treisman J.E., and Hariharan I.K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105 (2001) 345-355
117. Teleman A.A., Hietakangas V., Sayadian A.C., and Cohen S.M. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 7 (2008) 21
118. Thao D.T., Seto H., and Yamaguchi M. Drosophila Myc is required for normal DREF gene expression. Exp. Cell Res. 314 (2008) 184-192
119. Trumpp A., Refaeli Y., Oskarsson T., Gasser S., Murphy M., Martin G.R., and Bishop J.M. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414 (2001) 768-773
120. Tyler D.M., Li W., Zhuo N., Pellock B., and Baker N.E. Genes affecting cell competition in Drosophila. Genetics 175 (2007) 643-657
121. Vita M., and Henriksson M. The Myc oncoprotein as a therapeutic target for human cancer. Semin. Cancer Biol. 16 (2006) 318
122. Wang H., Somers G.W., Bashirullah A., Heberlein U., Yu F., and Chia W. Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 20 (2006) 3453-3463
123. Wood M.A., McMahon S.B., and Cole M.D. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol. Cell 5 (2000) 321-330
124. Xu T., and Harrison S.D. Mosaic analysis using FLP recombinase. (Review). Methods Cell Biol. 44 (1994) 655-681
125. Xue L., and Noll M. Dual role of the Pax gene paired in accessory gland development of Drosophila. Development 129 (2002) 339-346
126. Yuan J., Tirabassi R.S., Bush A.B., and Cole M.D. The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX. Oncogene 17 (1998) 1109-1118
127. Zaffran S., Chartier A., Gallant P., Astier M., Arquier N., Doherty D., Gratecos D., and Semeriva M. A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Development 125 (1998) 3571-3584
128. Zhang H.H., Lipovsky A.I., Dibble C.C., Sahin M., and Manning B.D. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol. Cell 24 (2006) 185-197
129. Ziv O., Suissa Y., Neuman H., Dinur T., Geuking P., Rhiner C., Portela M., Lolo F., Moreno E., and Gerlitz O. The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling. Development 136 (2009) 1137-1145