Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation

Molecular and Cellular Biology

Volumn 24, Issue 4, 2004, Pages 1560-1569

  Nilsson, Jonas A ^a   Maclean, Kirsteen H ^a   Keller, Ulrich B ^a   Pendeville, Helene ^a   Baudino, Troy A ^a   Cleveland, John L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAX PROTEIN; MESSENGER RNA; MNT PROTEIN; MYC PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; ONCOPROTEIN MNT; ORNITHINE DECARBOXYLASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIVISION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DIMERIZATION; E BOX ELEMENT; FIBROBLAST; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; MOUSE STRAIN; NONHUMAN; NUTRITIONAL DEFICIENCY; ONCOGENE C MYC; ONCOGENE MYC; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, SUPPRESSOR; MICE; MICE, INBRED BALB C; NUCLEAR PROTEINS; ORNITHINE DECARBOXYLASE; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0842282553     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.4.1560-1569.2004     Document Type: Article

References (40)

1. Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915-1922.
2. Ayer, D. E., and R. N. Eisenman. 1993. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:2110-2119.
3. Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767-776.
4. Baudino, T. A., and J. L. Cleveland. 2001. The Max network gone Mad. Mol. Cell. Biol. 21:691-702.
5. Baudino, T. A., K. H. Maclean, J. Brennan, E. Parganas, C. Yang, A. Aslanian, J. A. Lees, C. J. Sherr, M. F. Roussel, and J. Cleveland. 2003. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compomised by E2f1 loss. Mol. Cell 11:1-20.
6. Baudino, T. A., C. McKay, H. Pendeville-Samain, J. A. Nilsson, K. H. Maclean, E. L. White, A. C. Davis, J. N. Ihle, and J. L. Cleveland. 2002. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 16:2530-2543.
7. Bello-Fernandez, C., G. Packham, and J. L. Cleveland. 1993. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA 90:7804-7808.
8. Blackwell, T. K., L. Kretzner, E. M. Blackwood, R. N. Eisenman, and H. Weintraub. 1990. Sequence-specific DNA binding by the c-Myc protein. Science 250:1149-1151.
9. Blackwood, E. M., B. Luscher, and R. N. Eisenman. 1992. Myc and Max associate in vivo. Genes Dev. 6:71-80.
10. Bouchard, C., O. Dittrich, A. Kiermaier, K. Dohmann, A. Menkel, M. Eilers, and B. Luscher. 2001. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev. 15:2042-2047.
11. Bush, A., M. Mateyak, K. Dugan, A. Obaya, S. Adachi, J. Sedivy, and M. Cole. 1998. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev. 12:3797-3802.
12. Davis, R. H., D. R. Morris, and P. Coffino. 1992. Sequestered end products and enzyme regulation: the case of ornithine decarboxylase. Microbiol. Rev. 56:280-290.
13. Eischen, C. M., D. Woo, M. F. Roussel, and J. L. Cleveland. 2001. Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol. Cell. Biol. 21:5063-5070.
14. Evan, G. I., A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128.
15. Foley, K. P., G. A. McArthur, C. Queva, P. J. Hurlin, P. Soriano, and R. N. Eisenman. 1998. Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J. 17:774-785.
16. Frank, S. R., M. Schroeder, P. Fernandez, S. Taubert, and B. Amati. 2001. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15:2069-2082.
17. Gomez-Roman, N., C. Grandori, R. N. Eisenman, and R. J. White. 2003. Direct activation of RNA polymerase III transcription by c-Myc. Nature 421:290-294.
18. Harrington, E. A., M. R. Bennett, A. Fanidi, and G. I. Evan. 1994. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13:3286-3295.
19. Hemann, M. T., J. S. Fridman, J. T. Zilfou, E. Hernando, P. J. Paddison, C. Cordon-Cardo, G. J. Hannon, and S. W. Lowe. 2003. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet. 33:396-400.
20. Hurlin, P. J., C. Queva, and R. N. Eisenman. 1997. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes. Dev. 11:44-58.
21. Hurlin, P. J., Z. Q. Zhou, K. Toyo-oka, S. Ota, H. L. Walker, S. Hirotsune, and A. Wynshaw-Boris. 2003. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 22:4584-4596.
22. Land, H., L.-F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304:596-602.
23. Lindstrom, M. S., and K. G. Wiman. 2003. Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts. Oncogene 22:4993-5005.
24. Littlewood, T. D., B. Amati, H. Land, and G. I. Evan. 1992. Max and c-Myc/Max DNA-binding activities in cell extracts. Oncogene 7:1783-1792.
25. Littlewood, T. D., D. C. Hancock, P. S. Danielian, M. G. Parker, and G. I. Evan. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
26. Maclean, K. H., U. Keller, C. Rodriguez-Galindo, J. A. Nilsson, and J. L. Cleveland. 2003. c-Myc augments gamma-irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23:7256-7270.
27. Mateyak, M. K., A. J. Obaya, S. Adachi, and J. M. Sedivy. 1997. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ. 8:1039-1048.
28. McMahon, S. B., H. A. Van Buskirk, K. A. Dugan, T. D. Copeland, and M. D. Cole. 1998. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94:363-374.
29. Meroni, G., A. Reymond, M. Alcalay, G. Borsani, A. Tanigami, R. Tonlorenzi, C. L. Nigro, S. Messali, M. Zollo, D. H. Ledbetter, R. Brent, A. Ballabio, and R. Carrozzo. 1997. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J. 16:2892-2906.
30. Momand, J., and G. P. Zambetti. 1996. Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics. Oncogene 12:2279-2289.
31. Nilsson, J., S. Koskiniemi, K. Persson, B. Grahn, and I. Holm. 1997. Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse. Eur. J. Biochem. 250:223-231.
32. Packham, G., and J. L. Cleveland. 1997. Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways. Oncogene 15:1219-1232.
33. Pelengaris, S., M. Khan, and G. Evan. 2002. c-myc: more than just a matter of life and death. Nat. Rev. Cancer 2:764-776.
34. Pelengaris, S., T. Littlewood, M. Khan, G. Elia, and G. Evan. 1999. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3:565-577.
35. Queva, C., G. A. McArthur, B. M. Iritani, and R. N. Eisenman. 2001. Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol. Cell. Biol. 21:703-712.
36. Schreiber-Agus, N., Y. Meng, T. Hoang, H. Hou, Jr., K. Chen, R. Greenberg, C. Cordon-Cardo, H. W. Lee, and R. A. DePinho. 1998. Role of Mxil in ageing organ systems and the regulation of normal and neoplastic growth. Nature 393:483-487.
37. Sommer, A., A. Waha, J. Tonn, N. Sorensen, P. J. Hurlin, R. N. Eisenman, B. Luscher, and T. Pietsch. 1999. Analysis of the Max-binding protein MNT in human medulloblastomas. Int. J. Cancer 82:810-816.
38. Takahashi, T., H. Konishi, K. Kozaki, H. Osada, and S. Saji. 1998. Molecular analysis of a Myc antagonist, ROX/Mnt, at 17p13.3 in human lung cancers. Jpn. J. Cancer Res. 89:347-351.
39. Vlach, J., S. Hennecke, K. Alevizopoulos, D. Conti, and B. Amati. 1996. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 15:6595-6604.
40. Zindy, F., C. M. Eischen, D. H. Randle, T. Kamijo, J. L. Cleveland, C. J. Sherr, and M. F. Roussel. 1998. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12: 2424-2433.