Gestational exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin disrupts B-cell lymphopoiesis and exacerbates autoimmune disease in 24-week-old SNF1 mice

Toxicological Sciences

Volumn 112, Issue 1, 2009, Pages 133-143

  Mustafa, Amjad ^a   Holladay, Steven D ^b   Witonsky, Sharon ^c   Zimmerman, Kurt ^a   Reilly, Christopher M ^d   Sponenberg, D Phillip ^a   Weinstein, Danielle A ^a   Karpuzoglu, Ebru ^e   Gogal Jr , Robert M ^b  

^a CENTER FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^d EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^e BASKENT UNIVERSITY   (Turkey)

Author keywords

Autoimmunity; Lupus; Prenatal exposure; SNF1 mouse; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CARDIOLIPIN; CD1 ANTIGEN; CD23 ANTIGEN; CD24 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3D RECEPTOR; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BODY WEIGHT; BONE MARROW; CELL LINEAGE; CELL MIGRATION; DISEASE EXACERBATION; ENVIRONMENTAL EXPOSURE; FEMALE; GESTATION PERIOD; KIDNEY NECROSIS; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MALE; MOUSE; NEW ZEALAND BLACK MOUSE; NONHUMAN; OVARY FOLLICLE CELL; PHENOTYPE; PRE B LYMPHOCYTE; PROGENY; SPLEEN WEIGHT; SWISS WEBSTER MOUSE;

ANIMALS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; BODY WEIGHT; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MICE; ORGAN SIZE; SPLEEN; TETRACHLORODIBENZODIOXIN;

MUS;

EID: 71049151927     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp177     Document Type: Article

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