Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin I. Effects on the fetus and the neonate

Toxicology

Volumn 122, Issue 3, 1997, Pages 219-228

  Gehrs, Bradley C ^a   Riddle, Marie M ^b   Williams, Wanda C ^b   Smialowicz, Ralph J ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; F344 rat; Fetus; Neonate

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FETOTOXICITY; FETUS; IMMUNE DEFICIENCY; IMMUNOTOXICITY; NEWBORN; NONHUMAN; ORGAN WEIGHT; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; THYMUS ATROPHY;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETUS; FLOW CYTOMETRY; IMMUNE SYSTEM; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, INBRED F344; T-LYMPHOCYTE SUBSETS; TETRACHLORODIBENZODIOXIN; THYMUS GLAND;

ANIMALIA; RODENTIA;

EID: 0030815088     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00098-X     Document Type: Article

References (29)

1. Blaylock, B.L., Holladay, S.D., Comment, C.E., Heindel, J.J., Luster, M.I., 1992. Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112, 207-213.
2. Boyd, R.L., Hugo, P., 1991. Towards an integrated view of thymopoiesis. Immunol. Today 12, 71-79.
3. Boyd, R.L., Tucek, C.L., Godfrey, D.I., Izon, D.J., Wilson, T.J., Davidson, N.J., Bean, A.G.D., Ladyman, H.M., Ritter, M.A., Hugo, P., 1993. The thymic environment. Immunol. Today 14, 445-459.
4. Clarke, A.G., Kendall, M.D., 1994. The thymus in pregnancy: the interplay of neural, endocrine and immune influences. Immunol. Today 15, 545-551.
5. DeVito, M.J., Maier, W.E., Diliberto, J.J., Birnbaum, L.S., 1993. Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment. Fundam. Appl. Toxicol. 20, 125-130.
6. DeWaal, E.J., Schuurman, H.-J., Loeber, J.G., Van Loveren, H., Vos, J.G., 1992. Alterations in cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): An (immuno)histological study. Toxicol. Appl. Pharmacol. 115, 80-88.
7. Faith, R.E., Moore, J.A., 1977. Impairment of thymus-dependent immune function by exposure of the developing immune system to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J. Toxicol. Environ. Health 3, 451-464.
8. Fine, J.S., Gasiewicz, T.A., Silverstone, A.E., 1989. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol. 35, 18-25.
9. Fine, J.S., Gasiewicz, T.A., Fiore, N.C., Silverstone, A.E., 1990. Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. J. Pharmacol. Exp. Ther. 255, 128-132.
10. Gehrs, B.C., Riddle, M.M., Williams, W.C., Smialowicz, R.J., 1997. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. II. Effects on the pup and the adult. Toxicology 122, 229-240.
11. Greenlee, W.F., Dold, K.M., Irons, R.D., Osborne, R., 1985. Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium. Toxicol. Appl. Pharmacol. 79, 112-120.
12. Gupta, B.N., Vos, J.G., Moore, J.A., Zinkl, J.G., Bullock, B.C., 1973. Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals. Environ. Health Perspect. 5, 125-140.
13. Holladay, S.D., Lindstrom, P., Blaylock, B.L., Comment, C.E., Germolec, D.R., Heindell, J.J., Luster, M.I., 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin. Teratology 44, 385-393.
14. Jotereau, F., Heuze, F., Salomon-Vie, V., Gascan, H., 1987. Cell kinetics in the fetal mouse thymus: Precursor cell input, proliferation, and emigration. J. Immunol. 138, 1026-1030.
15. Kampinga, J., Aspinall, R., 1990. Thymocyte differentiation and thymic microenvironment development in the fetal rat thymus: an immunohistological approach. In: M.D. Kendall, M.A. Ritter, (Eds.), Thymus Update, vol. 3. Harwood Academic Publishers, London, pp. 149-186.
16. Kimura, M., Hanawa, H., Watanabe, H., Ogawa, M., Abo, T., 1995. Synchronous expansion of intermediate TCR cells in the liver and uterus during pregnancy. Cell. Immunol. 162, 16-25.
17. Korte, M., Stahlmann, R., Thiel, R., Nagao, T., Chahoud, I., van Loveren, H., Vos, J.G., Neubert, D., 1991. Resistance to Trichinella spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23, 1845-1854.
18. Kremer, J., Gleichman, E., Esser, C., 1994. Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation. J. Immunol. 153, 2778-2786.
19. Kremer, J., Lai, Z.-W., Esser, C., 1995. Evidence for the promotion of positive selection of thymocytes by Ah recptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Eur. J. Pharmacol. 293, 413-427.
20. Lundberg, K., Grönvik, K.-O., Goldschmidt, T.J., Klareskog, L., Dencker, L., 1990. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T-cell development in mice. Chem.-Biol. Interactions 74, 179-193.
21. 2+-mediated endonuclease activation. Science 242, 256-259.
22. Nau, H., Bass, R., 1981. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the mouse embryo and fetus. Toxicology 20, 299-308.
23. Poland, A., Knutson, J.C., 1982. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554.
24. RS/1, 1988. RS/1 Release 4. BBN Software Products Corp., Cambridge, MA.
25. Safe, S.H., 1986. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399.
26. Smialowicz, R.J., Riddle, M.M., Williams, W.C., Diliberto, J.J., 1994. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: Differences between mice and rats. Toxicol. Appl. Pharmacol. 124, 248-256.
27. Van den Berg, M., Heeremans, C., Veenhoven, E., Olie, K., 1987. Transfer of polychlorinated dibenzo-p -dioxins and dibenzofurans to fetal and neonatal rats. Fundam. Appl. Toxicol. 9, 635-644.
28. Vos, J.G., Moore, J.A., Zinkl, J.G., 1973. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ. Health Perspect. 5, 149-162.
29. Vos, J.G., Moore, J.A., 1974. Suppression of cellular immunity in rats and mice by maternal treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Int. Arch. Allergy 47, 777-794.