B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity

Journal of Dermatological Science

Volumn 46, Issue 1, 2007, Pages 1-9

  Fujimoto, Manabu ^a   Sato, Shinichi ^b  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Autoimmunity; CD19; CD22; Systemic sclerosis; Tight skin mouse

Indexed keywords

CD19 ANTIGEN; CD22 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE LYN; PROTEIN TYROSINE PHOSPHATASE SHP 1;

ANTIGENIC MODULATION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CELL SPECIFICITY; CELL SURFACE; ENZYME ACTIVITY; HUMAN; LYMPHOCYTE FUNCTION; MICROENVIRONMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SKIN; STATISTICAL ANALYSIS;

ANIMALS; ANTIGENS, CD19; ANTIGENS, CD22; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; HUMANS; SIGNAL TRANSDUCTION;

EID: 33847636073     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2006.12.004     Document Type: Review

References (55)

1. Martin F., and Chan A.C. B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol 24 (2006) 467-496
2. Tedder T.F. Response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction. Semin Immunol 10 (1998) 259-265
3. Tsubata T. Co-receptors on B lymphocytes. Curr Opin Immunol 11 (1999) 249-255
4. Fujimoto M., Poe J.C., Hasegawa M., and Tedder T.F. CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. Immunol Res 22 (2001) 281-298
5. Cyster J.G., and Goodnow C.C. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity 6 5 (1997) 509-517
6. Nitschke L., and Tsubata T. Molecular interactions regulate BCR signal inhibition by CD22 and CD72. Trends Immunol 25 (2004) 543-550
7. Korganow A.S., Ji H., Mangialaio S., Duchatelle V., Pelanda R., Martin T., et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 10 (1999) 451-461
8. Matsumoto I., Staub A., Benoist C., and Mathis D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286 (1999) 1732-1735
9. Matsumoto I., Maccioni M., Lee D.M., Maurice M., Simmons B., Brenner M., et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 3 (2002) 360-365
10. Matsumoto I., Lee D.M., Goldbach-Mansky R., Sumida T., Hitchon C.A., Schur P.H., et al. Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum 48 (2003) 944-954
11. Lipsky P.E. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2 (2001) 764-766
12. Chan O., and Shlomchik M.J. A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J Immunol 160 (1998) 51-59
13. Chan O.T., Hannum L.G., Haberman A.M., Madaio M.P., and Shlomchik M.J. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189 (1999) 1639-1648
14. Shlomchik M.J., Craft J.E., and Mamula M.J. From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol 1 (2001) 147-153
15. Browning J.L. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nat Rev Drug Discov 5 (2006) 564-576
16. Tedder T.F., Inaoki M., and Sato S. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 6 (1997) 107-118
17. Cherukuri A., Shoham T., Sohn H.W., Levy S., Brooks S., Carter R., et al. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol 172 (2004) 370-380
18. Tsitsikov E.N., Gutierrez-Ramos J.C., and Geha R.S. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci USA 94 (1997) 10844-10849
19. Fujimoto M., Poe J.C., Jansen P.J., Sato S., and Tedder T.F. CD19 amplifies B lymphocyte signal transduction by regulating Src- family protein tyrosine kinase activation. J Immunol 162 (1999) 7088-7094
20. Fujimoto M., Fujimoto Y., Poe J.C., Jansen P.J., Lowell C.A., DeFranco A.L., et al. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 13 (2000) 47-57
21. Yazawa N., Fujimoto M., Sato S., Miyake K., Asano N., Nagai Y., et al. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102 (2003) 1374-1380
22. Weng W.K., Jarvis L., and LeBien T.W. Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3- kinase complex in human B cell precursors. J Biol Chem 269 (1994) 32514-32521
23. Tuveson D.A., Carter R.H., Soltoff S.P., and Fearon D.T. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260 (1993) 986-989
24. Buhl A.M., and Cambier J.C. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor- mediated activation of Bruton's tyrosine kinase. J Immunol 162 (1999) 4438-4446
25. Fujimoto M., Poe J.C., Satterthwaite A.B., Wahl M.I., Witte O.N., and Tedder T.F. Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. J Immunol 168 (2002) 5465-5476
26. Engel P., Zhou L.J., Ord D.C., Sato S., Koller B., and Tedder T.F. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3 (1995) 39-50
27. Rickert R.C., Rajewsky K., and Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376 (1995) 352-355
28. Sato S., Steeber D.A., Jansen P.J., and Tedder T.F. CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. J Immunol 158 (1997) 4662-4669
29. Inaoki M., Sato S., Weintraub B.C., Goodnow C.C., and Tedder T.F. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med 186 (1997) 1923-1931
30. Tedder T.F., Poe J.C., and Haas K.M. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol 88 (2005) 1-50
31. Fujimoto M., Kuwano Y., Watanabe R., Asashima N., Nakashima H., Yoshitake S., et al. B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. J Immunol 176 (2006) 873-879
32. Poe J.C., Fujimoto M., Jansen P.J., Miller A.S., and Tedder T.F. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem 275 (2000) 17420-17427
33. Fujimoto M., Bradney A.P., Poe J.C., Steeber D.A., and Tedder T.F. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity 11 (1999) 191-200
34. Sato S., Miller A.S., Inaoki M., Bock C.B., Jansen P.J., Tang M.L., et al. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5 (1996) 551-562
35. O'Keefe T.L., Williams G.T., Davies S.L., and Neuberger M.S. Hyperresponsive B cells in CD22-deficient mice. Science 274 (1996) 798-801
36. Cherukuri A., Cheng P.C., Sohn H.W., and Pierce S.K. The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. Immunity 14 (2001) 169-179
37. Fujimoto M., Poe J.C., Hasegawa M., and Tedder T.F. CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. J Biol Chem 276 48 (2001) 44820-44827
38. Lyubchenko T., dal Porto J., Cambier J.C., and Holers V.M. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway. J Immunol 174 (2005) 3264-3272
39. Fujimoto M., and Sato S. B lymphocytes and systemic sclerosis. Curr Opin Rheumatol 17 (2005) 746-751
40. Tedder T.F., Poe J.C., Fujimoto M., Haas K.M., and Sato S. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Curr Dir Autoimmun 8 (2005) 55-90
41. Xu Y., Harder K.W., Huntington N.D., Hibbs M.L., and Tarlinton D.M. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22 (2005) 9-18
42. O'Keefe T.L., Williams G.T., Batista F.D., and Neuberger M.S. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 189 (1999) 1307-1313
43. Painter C.J., Monestier M., Chew A., Bona-Dimitriu A., Kasturi K., Bailey C., et al. Specificities and V genes encoding monoclonal autoantibodies from viable motheaten mice. J Exp Med 167 (1988) 1137-1153
44. Hasegawa M., Fujimoto M., Takehara K., and Sato S. Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis. J Dermatol Sci 39 (2005) 1-7
45. Siracusa L.D., McGrath R., Ma Q., Moskow J.J., Manne J., Christner P.J., et al. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res. 6 (1996) 300-313
46. Saito S., Nishimura H., Phelps R.G., Wolf I., Suzuki M., Honjo T., et al. Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene. Mol Med 6 10 (2000) 825-836
47. Wallace V.A., Kondo S., Kono T., Xing Z., Timms E., Furlonger C., et al. A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol 24 (1994) 1463-1466
48. Kodera T., McGaha T.L., Phelps R., Paul W.E., and Bona C.A. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc Natl Acad Sci USA 99 (2002) 3800-3805
49. Zhu H., Bona C., and McGaha T.L. Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice. Autoimmunity 37 (2004) 51-55
50. Saito E., Fujimoto M., Hasegawa M., Komura K., Hamaguchi Y., Kaburagi Y., et al. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the Tight Skin mice. J Clin Invest 109 (2002) 1453-1462
51. Asano N., Fujimoto M., Yazawa N., Shirasawa S., Hasegawa M., Okochi H., et al. B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol 165 (2004) 641-650
52. Sato S., Hasegawa M., Fujimoto M., Tedder T.F., and Takehara K. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 165 (2000) 6635-6643
53. Sato S., Fujimoto M., Hasegawa M., and Takehara K. Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum 50 6 (2004) 1918-1927
54. Sato S., Fujimoto M., Hasegawa M., Takehara K., and Tedder T.F. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Mol Immunol 41 (2004) 1123-1133
55. Matsushita T., Fujimoto M., Hasegawa M., Komura K., Takehara K., Tedder T.F., et al. Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. Am J Pathol 168 (2006) 812-821