Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

BMC Cancer

Volumn 9, Issue , 2009, Pages 383-

  Snow, Grace E ^a   Kasper, Allison C ^a   Busch, Alexander M ^a   Schwarz, Elisabeth ^a   Ewings, Katherine E ^a   Bee, Thomas ^a   Spinella, Michael J ^a,b   Dmitrovsky, Ethan ^a,b   Freemantle, Sarah J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b NORRIS COTTON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED PROTEIN; FRIZZLED PROTEIN 10; FRIZZLED PROTEIN 5; FRIZZLED PROTEIN 6; FRIZZLED PROTEIN 7; OCTAMER TRANSCRIPTION FACTOR 4; RETINOIC ACID; UNCLASSIFIED DRUG; WNT PROTEIN; WNT2 PROTEIN; WNT2B PROTEIN; WNT5A PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONAL CARCINOMA; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PLURIPOTENT STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION;

EID: 70749092046     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-383     Document Type: Article

References (50)

1. Andrews PW. Teratocarcinomas and human embryology: pluripotent human EC cell lines. Review article. APMIS 1998, 106(1):158-167. discussion 167-158., 10.1111/j.1699-0463.1998.tb01331.x, 9524574.
2. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci USA 2003, 100(23):13350-13355. 263817, 14595015, 10.1073/pnas.2235735100.
3. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810. 10.1146/annurev.cellbio.20.010403.113126, 15473860.
4. van Amerongen R, Mikels A, Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal 2008, 1(35):re9. 10.1126/scisignal.135re9, 18765832.
5. Chien AJ, Conrad WH, Moon RT. A Wnt survival guide: from flies to human disease. J Invest Dermatol 2009, 129(7):1614-1627. 10.1038/jid.2008.445, 19177135.
6. Nusse R. Wnt signaling and stem cell control. Cell Res 2008, 18(5):523-527. 10.1038/cr.2008.47, 18392048.
7. Nusse R, Fuerer C, Ching W, Harnish K, Logan C, Zeng A, ten Berge D, Kalani Y. Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol 2008, 73:59-66.
8. Freemantle SJ, Kerley JS, Olsen SL, Gross RH, Spinella MJ. Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma. Oncogene 2002, 21(18):2880-2889. 10.1038/sj.onc.1205408, 11973648.
9. Dmitrovsky E, Murty VV, Moy D, Miller WH, Nanus D, Albino AP, Samaniego F, Bosl G, Chaganti RS. Isochromosome 12p in non-seminoma cell lines: karyologic amplification of c-ki-ras2 without point-mutational activation. Oncogene 1990, 5(4):543-548.
10. Moasser MM, Khoo KS, Maerz WJ, Zelenetz A, Dmitrovsky E. Derivation and characterization of retinoid-resistant human embryonal carcinoma cells. Differentiation 1996, 60(4):251-257. 10.1046/j.1432-0436.1996.6040251.x, 8765055.
11. White KA, Yore MM, Warburton SL, Vaseva AV, Rieder E, Freemantle SJ, Spinella MJ. Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. J Biol Chem 2003, 278(45):43889-43892. 10.1074/jbc.C300374200, 14506269.
12. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E. Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism. Proc Natl Acad Sci USA 1997, 94(22):12070-12074. 23705, 9342364, 10.1073/pnas.94.22.12070.
13. Hendriksen J, Jansen M, Brown CM, Velde H, van Ham M, Galjart N, Offerhaus GJ, Fagotto F, Fornerod M. Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway. J Cell Sci 2008, 121(Pt 11):1793-1802. 10.1242/jcs.025536, 18460581.
14. Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J Biol Chem 1999, 274(31):22013-22018. 10.1074/jbc.274.31.22013, 10419526.
15. Andrews PW, Nudelman E, Hakomori S, Fenderson BA. Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR). Differentiation 1990, 43(2):131-138. 10.1111/j.1432-0436.1990.tb00439.x, 2373286.
16. Freemantle SJ, Vaseva AV, Ewings KE, Bee T, Krizan KA, Kelley MR, Hattab EM, Memoli VA, Black CC, Spinella MJ. Repression of cyclin D1 as a target for germ cell tumors. Int J Oncol 2007, 30(2):333-340.
17. Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown DT, Misteli T. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 2006, 10(1):105-116. 1868458, 16399082, 10.1016/j.devcel.2005.10.017.
18. van Noort M, Meeldijk J, Zee R, Destree O, Clevers H. Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem 2002, 277(20):17901-17905. 10.1074/jbc.M111635200, 11834740.
19. Wakeman JA, Walsh J, Andrews PW. Human Wnt-13 is developmentally regulated during the differentiation of NTERA-2 pluripotent human embryonal carcinoma cells. Oncogene 1998, 17(2):179-186. 10.1038/sj.onc.1201942, 9674702.
20. Lu MF, Pressman C, Dyer R, Johnson RL, Martin JF. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature 1999, 401(6750):276-278. 10.1038/45797, 10499585.
21. Sangster-Guity N, Yu LM, McCormick P. Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. Cancer Biol Ther 2004, 3(11):1109-1120.
22. Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 2005, 132(21):4789-4800. 10.1242/dev.02031, 16207763.
23. Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J. Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 2002, 111(5):673-685. 10.1016/S0092-8674(02)01084-X, 12464179.
24. Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003, 116(Pt 13):2627-2634. 10.1242/jcs.00623, 12775774.
25. Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene 2009, 28(8):1110-1120. 10.1038/onc.2008.467, 19137009.
26. Fogh J. Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors. Natl Cancer Inst Monogr 1978, (49):5-9.
27. Bronson DL, Andrews PW, Solter D, Cervenka J, Lange PH, Fraley EE. Cell line derived from a metastasis of a human testicular germ cell tumor. Cancer Res 1980, 40(7):2500-2506.
28. Moasser MM, Motzer RJ, Khoo KS, Lyn P, Murphy BA, Bosl GJ, Dmitrovsky E. all-trans retinoic acid for treating germ cell tumors. In vitro activity and results of a phase II trial. Cancer 1995, 76(4):680-686. 10.1002/1097-0142(19950815)76:4<680::AID-CNCR2820760423>3.0.CO;2-9, 8625166.
29. Miller WH, Moy D, Li A, Grippo JF, Dmitrovsky E. Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line. Oncogene 1990, 5(4):511-517.
30. Nusse R, Fuerer C, Ching W, Harnish K, Logan C, Zeng A, Ten Berge D, Kalani Y. Wnt Signaling and Stem Cell Control. Cold Spring Harb Symp Quant Biol 2008, 73:59-66.
31. ten Berge D, Koole W, Fuerer C, Fish M, Eroglu E, Nusse R. Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell 2008, 3(5):508-518. 2683270, 18983966, 10.1016/j.stem.2008.09.013.
32. Sumi T, Tsuneyoshi N, Nakatsuji N, Suemori H. Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling. Development 2008, 135(17):2969-2979. 10.1242/dev.021121, 18667462.
33. Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L. Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 2005, 23(10):1489-1501. 10.1634/stemcells.2005-0034, 16002782.
34. Fritsch MK, Schneider DT, Schuster AE, Murdoch FE, Perlman EJ. Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Pediatr Dev Pathol 2006, 9(2):115-131. 10.2350/08-05-0097.1, 16822086.
35. Honecker F, Kersemaekers AM, Molier M, Van Weeren PC, Stoop H, De Krijger RR, Wolffenbuttel KP, Oosterhuis W, Bokemeyer C, Looijenga LH. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol 2004, 204(2):167-174. 10.1002/path.1614, 15378486.
36. Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 2006, 4(4):e115. 1420652, 16602827, 10.1371/journal.pbio.0040115.
37. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006, 38(4):431-440. 10.1038/ng1760, 16518401.
38. Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T, Adjaye J. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 2007, 25(2):500-510. 10.1634/stemcells.2006-0426, 17068183.
39. Katoh Y, Katoh M. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Int J Oncol 2007, 30(3):751-755.
40. Walsh J, Andrews PW. Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell. APMIS 2003, 111(1):197-210. discussion 210-191., 10.1034/j.1600-0463.2003.1110124.x, 12760378.
41. Teo JL, Ma H, Nguyen C, Lam C, Kahn M. Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci USA 2005, 102(34):12171-12176. 1189325, 16093313, 10.1073/pnas.0504600102.
42. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci USA 2007, 104(13):5668-5673. 1838514, 17372190, 10.1073/pnas.0701331104.
43. Li J, Sutter C, Parker DS, Blauwkamp T, Fang M, Cadigan KM. CBP/p300 are bimodal regulators of Wnt signaling. EMBO J 2007, 26(9):2284-2294. 1864967, 17410209, 10.1038/sj.emboj.7601667.
44. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002, 1(3):279-288. 10.1016/S1535-6108(02)00045-4, 12086864.
45. Merle P, Kim M, Herrmann M, Gupte A, Lefrancois L, Califano S, Trepo C, Tanaka S, Vitvitski L, de la Monte S. Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. J Hepatol 2005, 43(5):854-862. 10.1016/j.jhep.2005.05.018, 16098625.
46. Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 2008, 10(7):697-705. 2435005, 18592008.
47. Melchior K, Weiss J, Zaehres H, Kim YM, Lutzko C, Roosta N, Hescheler J, Muschen M. The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem 2008, 389(7):897-903. 10.1515/BC.2008.108, 18681827.
48. Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG. Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 2008, 320(5874):365-369. 10.1126/science.1151250, 18420933.
49. Maltman DJ, Christie VB, Collings JC, Barnard JH, Fenyk S, Marder TB, Whiting A, Przyborski SA. Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol Biosyst 2009, 5(5):458-471. 10.1039/b817912c, 19381361.
50. Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res 2007, 67(2):573-579. 10.1158/0008-5472.CAN-06-2726, 17234765.