Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords

Behavioural Brain Research

Volumn 207, Issue 1, 2010, Pages 30-36

  Lin, Shinn Long ^a,b   Tsai, Ru Yin ^a   Tai, Yueh Hua ^b   Cherng, Chen Hwen ^b   Wu, Ching Tang ^b   Yeh, Chun Chang ^b   Wong, Chih Shung ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Anti inflammatory cytokine; Interleukin 10; Morphine tolerance; Neuroinflammation; Pro inflammatory cytokine; Ultra low dose naloxone

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MORPHINE; NALOXONE; RECOMBINANT INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; DRUG TOLERANCE; LOW DRUG DOSE; MALE; MYELITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; SPINAL CORD; UPREGULATION; WISTAR RAT;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, NEUTRALIZING; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG TOLERANCE; INFLAMMATION; INJECTIONS, SPINAL; INTERLEUKIN-10; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; UP-REGULATION;

EID: 70649112194     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.09.034     Document Type: Article

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