Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats

Neuropsychopharmacology

Volumn 33, Issue 11, 2008, Pages 2772-2782

  Tsai, Ru Yin ^a   Jang, Fong Lin ^b   Tai, Yueh Hua ^a   Lin, Shinn Long ^a,c   Shen, Ching Hui ^a,d   Wong, Chih Shung ^c  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Excitatory amino acid; IL 1 ; IL 6; Opioid receptor; Pro inflammatory cytokine; TNF

Indexed keywords

EXCITATORY AMINO ACID; GLUTAMATE TRANSPORTER; MORPHINE; NALOXONE; PERTUSSIS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; GENE SEQUENCE; HYPERALGESIA; LOW DRUG DOSE; MALE; MICROGLIA; MYELITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANALGESICS, OPIOID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; MALE; MORPHINE; NALOXONE; PAIN; PAIN MEASUREMENT; PERTUSSIS TOXIN; RATS; RATS, WISTAR; SPINAL CORD;

EID: 51749085166     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301672     Document Type: Article

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