Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex

International Journal of Pharmaceutics

Volumn 350, Issue 1-2, 2008, Pages 205-211

  Piao, Zong Zhu ^a   Lee, Mi Kyung ^b   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Woosuk University   (South Korea)

Author keywords

Colonic release; Different coated structures; Inclusion complex; Naproxen; Reduced intestinal tissue damage

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALUMINUM HYDROXIDE; CROSCARMELLOSE SODIUM; CROSPOVIDONE; EUDRAGIT; EUDRAGIT RS; MICROCRYSTALLINE CELLULOSE; NAPROXEN; SEBACIC ACID DIBUTYL ESTER; STARCH GLYCOLATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; HISTOLOGY; IN VITRO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STOMACH JUICE; TABLET COMPRESSION; TABLET FORMULATION; TISSUE INJURY;

ACRYLIC RESINS; ANIMALS; BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; COLON; HYDROGEN-ION CONCENTRATION; INTESTINES; MALE; NAPROXEN; POLYMETHACRYLIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 38349118267     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.08.044     Document Type: Article

References (13)

1. Ashford M., Fell J.T., Attwood D., and Woodhead P.J. An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting. Int. J. Pharm. 91 (1993) 241-245
2. Chourasia M.K., and Jain S.K. Design and development of multiparticulate system for targeted drug delivery to colon. Drug Deliv. 11 (2004) 201-207
3. Espinar F.J., Anguiano-Igea S., Blanco-Méndez J., and Vila-Jato J.L. Reduction in the ulcerogenicity of naproxen by complexation with β-cyclodextrin. Int. J. Pharm. 70 (1991) 35-41
4. Kim T.-W., Ji C.-W., Shim S.-Y., and Lee B.-J. Modified release of coated sugar spheres using drug-containing polymeric suspensions. Arch. Pharm. Res. 30 (2007) 124-130
5. Kim T.-W., Sah H.K., and Lee B.-J. Characterization of dual layered pellets for sustained release of poorly water-soluble drug. Chem. Pharm. Bull. 55 (2007) 975-979
6. Larsen C., Harboe E., Johansen M., and Olesen H.P. Macromolecular prodrugs. XVI. colon-targeted delivery-comparison of the rate of release of naproxen from dextran ester prodrugs in homogenates of various segments of the pig gastrointestinal (GI) tract. Pharm. Res. 6 (1989) 995-999
7. Lee B.-J., and Lee J.-R. Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-β-cyclodextrin. Arch. Pharm. Res. 18 (1995) 22-26
8. Lee B.-J., Ryu S.-G., and Cui J.-H. Controlled release of dual drug-loaded hydroxypropyl methylcellulose matrix tablet using drug-containing polymeric coatings. Int. J. Pharm. 188 (1999) 71-80
9. Mura P., Maestrelli F., and Cirri M. Ternary systems of naproxen with hydroxypropyl-β-cyclodextrin and aminoacids. Int. J. Pharm. 260 (2003) 293-302
10. Rao K.P., Prabhashankar B., Kumar A., Khan A., Biradar S.S., Srishail S.P., and Satyanath B. Formulation and roentgenographic studies of naproxen-pectin-based matrix tablets for colon drug delivery. Yale J. Biol. Med. 76 (2003) 149-154
11. Rodríguez L.A.G. Nonsteroidal anti-inflammatory drugs, ulcers and risk: a collaborative meta-analysis. Semin. Arthritis Rheum. 26 (1997) 16-20
12. Rubinstein A. Colonic drug delivery. Drug Discov. Today: Technol. 2 (2005) 33-36
13. Wilder-Smith C.H., Jonzon B., Fornstedt-Wallin B., Hedman A., and Karlsson C. Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. Scand. J. Gastroenterol. 41 (2006) 264-273