-
1
-
-
18244405359
-
In silico modelling of ADMET - A minireview of work from 2000 to 2004
-
Norinder U. In silico modelling of ADMET - a minireview of work from 2000 to 2004. SAR QSAR Environ Res 2005; 16: 1-11.
-
(2005)
SAR QSAR Environ Res
, vol.16
, pp. 1-11
-
-
Norinder, U.1
-
2
-
-
0037364162
-
ADMET in silico modelling: Towards prediction paradise?
-
van deWaterbeemd H, Gifford E. ADMET in silico modelling: towards prediction paradise? Nat Rev Drug Discov 2003; 2: 192-204.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 192-204
-
-
Van Dewaterbeemd, H.1
Gifford, E.2
-
5
-
-
0346728708
-
Intestinal membrane transport of drugs and nutrients: Genomics of membrane transporters using expression microarrays
-
DOI 10.1016/S0928-0987(03)00169-6
-
Anderle P, Huang Y, Sadee W. Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays. Eur J Pharm Sci 2004; 21: 17-24. (Pubitemid 38050201)
-
(2004)
European Journal of Pharmaceutical Sciences
, vol.21
, Issue.1
, pp. 17-24
-
-
Anderle, P.1
Huang, Y.2
Sadee, W.3
-
6
-
-
27644577325
-
Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling
-
DOI 10.1186/1471-2105-6-S2-S6
-
Fang H, Tong W, Perkins R, et al. Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling. BMC Bioinformatics 2005; 6(Suppl 2): S6. (Pubitemid 41574321)
-
(2005)
BMC Bioinformatics
, vol.6
, Issue.SUPPL. 2
-
-
Fang, H.1
Tong, W.2
Perkins, R.3
Shi, L.4
Hong, H.5
Cao, X.6
Xie, Q.7
Yim, S.H.8
Ward, J.M.9
Pitot, H.C.10
Dragan, Y.P.11
-
7
-
-
0038637117
-
Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters
-
DOI 10.1124/jpet.103.051011
-
Landowski CP, Sun D, Foster DR, et al. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. J Pharmacol Exp Ther 2003; 306: 778-786. (Pubitemid 36886180)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.306
, Issue.2
, pp. 778-786
-
-
Landowski, C.P.1
Sun, D.2
Foster, D.R.3
Menon, S.S.4
Barnett, J.L.5
Welage, L.S.6
Ramachandran, C.7
Amidon, G.L.8
-
8
-
-
0141569628
-
Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAs in rat small intestine
-
DOI 10.1124/dmd.31.10.1235
-
Takara K, Ohnishi N, Horibe S, Yokoyama T. Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAS in small intestine. Drug Metab Dispos 2003; 31: 1235-1239. (Pubitemid 37152974)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, Issue.10
, pp. 1235-1239
-
-
Takara, K.1
Ohnishi, N.2
Horibe, S.3
Yokoyama, T.4
-
9
-
-
0036783335
-
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
-
DOI 10.2174/1389200023337171
-
Rushmore TH, Kong AN. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 2002; 3: 481-490. (Pubitemid 34987481)
-
(2002)
Current Drug Metabolism
, vol.3
, Issue.5
, pp. 481-490
-
-
Rushmore, T.H.1
Kong, A.-N.T.2
-
10
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
DOI 10.1124/pr.55.3.1
-
Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 2003; 55: 425-461. (Pubitemid 37013212)
-
(2003)
Pharmacological Reviews
, vol.55
, Issue.3
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
11
-
-
70549108401
-
The importance of gut wall metabolism in determining drug bioavailability
-
Waterbeemd HV-d, Lennernas H, Artursson P (eds).Weinheim: Wiley-VCH
-
Beaumont K. The importance of gut wall metabolism in determining drug bioavailability. In Drug Bioavailability/Estimation of Solubility, Permeability and Absorption. Volume 18, Methods and Principles in Medicinal Chemistry, Waterbeemd HV-d, Lennernas H, Artursson P (eds).Weinheim: Wiley-VCH, 2003; 311-328.
-
(2003)
Drug Bioavailability/Estimation of Solubility, Permeability and Absorption. Volume 18, Methods and Principles in Medicinal Chemistry
, pp. 311-328
-
-
Beaumont, K.1
-
12
-
-
0042391834
-
Transporter-mediated drug interactions
-
Tsuji A. Transporter-mediated drug interactions. Drug Metab Pharmacokinet 2002; 17: 253-274.
-
(2002)
Drug Metab Pharmacokinet
, vol.17
, pp. 253-274
-
-
Tsuji, A.1
-
13
-
-
33746903600
-
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model
-
DOI 10.1007/s11095-006-9041-2
-
Cao X, Gibbs ST, Fang L, et al. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm Res 2006; 23: 1675-1686. (Pubitemid 44200529)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.8
, pp. 1675-1686
-
-
Cao, X.1
Gibbs, S.T.2
Fang, L.3
Miller, H.A.4
Landowski, C.P.5
Shin, H.-C.6
Lennernas, H.7
Zhong, Y.8
Amidon, G.L.9
Yu, L.X.10
Sun, D.11
-
14
-
-
33645990311
-
A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: Structure-kinetics relationship assessment
-
Bu HZ. A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: structure-kinetics relationship assessment. Curr Drug Metab 2006; 7: 231-249.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 231-249
-
-
Bu, H.Z.1
-
15
-
-
3442875587
-
The role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions
-
DOI 10.2174/1389450043345263
-
Berecz R, Dorado P, De La Rubia A, et al. The role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions. Curr Drug Targets 2004; 5: 573-579. (Pubitemid 39004432)
-
(2004)
Current Drug Targets
, vol.5
, Issue.6
, pp. 573-579
-
-
Berecz, R.1
Dorado, P.2
De La Rubia, A.3
Caceres, M.C.4
Degrell, I.5
Llerena, A.6
-
16
-
-
0036805724
-
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs
-
DOI 10.1023/A:1020483911355
-
Sun D, Lennernas H, Welage LS, et al. Comparison of human duodenum and Caco-2 gene expression profiles for 12000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res 2002; 19: 1400-1416. (Pubitemid 35266543)
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.10
, pp. 1400-1416
-
-
Sun, D.1
Lennernas, H.2
Welage, L.S.3
Barnett, J.L.4
Landowski, C.P.5
Foster, D.6
Fleisher, D.7
Lee, K.-D.8
Amidon, G.L.9
-
17
-
-
0029131555
-
Clinical importance of hepatic cytochrome P450 in drug metabolism
-
Spatzenegger M, Jaeger W. Clinical importance of hepatic cytochrome P450 in drug metabolism. Drug Metab Rev 1995; 27: 397-417.
-
(1995)
Drug Metab Rev
, vol.27
, pp. 397-417
-
-
Spatzenegger, M.1
Jaeger, W.2
-
18
-
-
0026644535
-
Drug metabolism by cytochromes P450 in the liver and small bowel
-
Watkins PB. Drug metabolism by cytochromes P450 in the liver and small bowel. Gastroenterol Clin North Am 1992; 21: 511-526.
-
(1992)
Gastroenterol Clin North Am
, vol.21
, pp. 511-526
-
-
Watkins, P.B.1
-
19
-
-
33644866971
-
Cytochrome P450 and anticancer drugs
-
Fujita K. Cytochrome P450 and anticancer drugs. Curr Drug Metab 2006; 7: 23-37.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 23-37
-
-
Fujita, K.1
-
21
-
-
0034973607
-
Cytochromes P450 and metabolism of xenobiotics
-
Anzenbacher P, Anzenbacherova E. Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 2001; 58: 737-747.
-
(2001)
Cell Mol Life Sci
, vol.58
, pp. 737-747
-
-
Anzenbacher, P.1
Anzenbacherova, E.2
-
22
-
-
0031975185
-
Update: Clinically significant cytochrome P-450 drug interactions
-
Michalets EL. Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 1998; 18: 84-112. (Pubitemid 28059007)
-
(1998)
Pharmacotherapy
, vol.18
, Issue.1
, pp. 84-112
-
-
Michalets, E.L.1
-
23
-
-
0034264199
-
Mechanisms of drug metabolism - Implications for drug interaction
-
Sitkiewicz D. Mechanisms of drug metabolism - implications for drug interaction. Pol Merkuriusz Lek 2000; 9: 595-597.
-
(2000)
Pol Merkuriusz Lek
, vol.9
, pp. 595-597
-
-
Sitkiewicz, D.1
-
24
-
-
33646799507
-
Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine
-
DOI 10.1124/dmd.105.009035
-
Martignoni M, Groothuis G, de Kanter R. Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine. Drug Metab Dispos 2006; 34: 1047-1054. (Pubitemid 43763764)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.6
, pp. 1047-1054
-
-
Martignoni, M.1
Groothuis, G.2
De Kanter, R.3
-
25
-
-
0142212150
-
Characterization of mouse small intestinal cytochrome P450 expression
-
DOI 10.1124/dmd.31.11.1346
-
Zhang QY, Dunbar D, Kaminsky LS. Characterization of mouse small intestinal cytochrome P450 expression. Drug Metab Dispos 2003; 31: 1346-1351. (Pubitemid 37310323)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, Issue.11
, pp. 1346-1351
-
-
Zhang, Q.-Y.1
Dunbar, D.2
Kaminsky, L.S.3
-
26
-
-
43749104916
-
Intestinal first-pass metabolism of CYP3A4 substrates
-
Kato M. Intestinal first-pass metabolism of CYP3A4 substrates. Drug Metab Pharmacokinet 2008; 23: 87-94.
-
(2008)
Drug Metab Pharmacokinet
, vol.23
, pp. 87-94
-
-
Kato, M.1
-
27
-
-
29944442940
-
Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: The contribution of cytochrome P450 3A isoforms
-
DOI 10.1124/dmd.105.006742
-
Shayeganpour A, El-Kadi AO, Brocks DR. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos 2006; 34: 43-50. (Pubitemid 43042645)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.1
, pp. 43-50
-
-
Shayeganpour, A.1
El-Kadi, A.O.S.2
Brocks, D.R.3
-
28
-
-
0031765907
-
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
-
DOI 10.1021/js980082d
-
Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 1998; 87: 1322-1330. (Pubitemid 28514135)
-
(1998)
Journal of Pharmaceutical Sciences
, vol.87
, Issue.11
, pp. 1322-1330
-
-
Wacher, V.J.1
Silverman, J.A.2
Zhang, Y.3
Benet, L.Z.4
-
29
-
-
33645800790
-
19nor-1,25-Dihydroxyvitamin D2 specifically induces CYP3A9 in rat intestine more strongly than 1,25-dihydroxyvitamin D3 in vivo and in vitro
-
Zierold C, Mings JA, Deluca HF. 19nor-1,25-Dihydroxyvitamin D2 specifically induces CYP3A9 in rat intestine more strongly than 1,25-dihydroxyvitamin D3 in vivo and in vitro. Mol Pharmacol 2006; 69: 1740-1747.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1740-1747
-
-
Zierold, C.1
Mings, J.A.2
Deluca, H.F.3
-
30
-
-
0037229516
-
Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: Site-directed active site mutagenesis to a progesterone dihydroxylase
-
DOI 10.1016/S0003-9861(02)00582-9, PII S0003986102005829
-
Xue L, Zgoda VG, Arison B, Almira Correia M. Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase. Arch Biochem Biophys 2003; 409: 113-126. (Pubitemid 36042907)
-
(2003)
Archives of Biochemistry and Biophysics
, vol.409
, Issue.1
, pp. 113-126
-
-
Xue, L.1
Zgoda, V.G.2
Arison, B.3
Correia, M.A.4
-
31
-
-
0032955185
-
Glutathione S-transferases - a review
-
Salinas AE, Wong MG. Glutathione S-transferases - a review. Curr Med Chem 1999; 6: 279-309.
-
(1999)
Curr Med Chem
, vol.6
, pp. 279-309
-
-
Salinas, A.E.1
Wong, M.G.2
-
32
-
-
0032437130
-
Human glutathione S-transferases
-
Whalen R, Boyer TD. Human glutathione S-transferases. Semin Liver Dis 1998; 18: 345-358.
-
(1998)
Semin Liver Dis
, vol.18
, pp. 345-358
-
-
Whalen, R.1
Boyer, T.D.2
-
33
-
-
0018368359
-
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents
-
Chasseaud LF. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv Cancer Res 1979; 29: 175-274.
-
(1979)
Adv Cancer Res
, vol.29
, pp. 175-274
-
-
Chasseaud, L.F.1
-
34
-
-
9644254340
-
Sulfotransferase structural biology and inhibitor discovery
-
DOI 10.1016/S1359-6446(04)03273-8, PII S1359644604032738
-
Rath VL, Verdugo D, Hemmerich S. Sulfotransferase structural biology and inhibitor discovery. Drug Discov Today 2004; 9: 1003-1011. (Pubitemid 39574556)
-
(2004)
Drug Discovery Today
, vol.9
, Issue.23
, pp. 1003-1011
-
-
Rath, V.L.1
Verdugo, D.2
Hemmerich, S.3
-
35
-
-
0020415697
-
Conjugation reactions in foreign-compound metabolism: Definition, consequences, and species variations
-
Caldwell J. Conjugation reactions in foreign-compound metabolism: definition, consequences, and species variations. Drug Metab Rev 1982; 13: 745-777. (Pubitemid 13242525)
-
(1982)
Drug Metabolism Reviews
, vol.13
, Issue.5
, pp. 745-777
-
-
Caldwell, J.1
-
36
-
-
13844299232
-
Integrating gene and protein expression data: Pattern analysis and profile mining
-
DOI 10.1016/j.ymeth.2004.08.021
-
Cox B, Kislinger T, Emili A. Integrating gene and protein expression data: pattern analysis and profile mining. Methods 2005; 35: 303-314. (Pubitemid 40255595)
-
(2005)
Methods
, vol.35
, Issue.3 SPEC.ISS
, pp. 303-314
-
-
Cox, B.1
Kislinger, T.2
Emili, A.3
-
37
-
-
0035999672
-
Analysis of mRNA expression and protein abundance data: An approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts
-
Greenbaum D, Jansen R, Gerstein M. Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts. Bioinformatics 2002; 18: 585-596. (Pubitemid 34525064)
-
(2002)
Bioinformatics
, vol.18
, Issue.4
, pp. 585-596
-
-
Greenbaum, D.1
Jansen, R.2
Gerstein, M.3
-
38
-
-
33845632906
-
Gene expression and regulation of drug transporters in the intestine and kidney
-
DOI 10.1016/j.bcp.2006.10.010, PII S0006295206006575
-
Terada T, Inui K. Gene expression and regulation of drug transporters in the intestine and kidney. Biochem Pharmacol 2007; 73: 440-449. (Pubitemid 44958370)
-
(2007)
Biochemical Pharmacology
, vol.73
, Issue.3
, pp. 440-449
-
-
Terada, T.1
Inui, K.-I.2
-
39
-
-
34247352929
-
Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine
-
DOI 10.1021/mp0600687
-
Berggren S, Gall C, Wollnitz N, et al. Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine. Mol Pharm 2007; 4: 252-257. (Pubitemid 46640601)
-
(2007)
Molecular Pharmaceutics
, vol.4
, Issue.2
, pp. 252-257
-
-
Berggren, S.1
Gall, C.2
Wollnitz, N.3
Ekelund, M.4
Karibom, U.5
Hoogstraate, J.6
Schrenk, D.7
Lennernas, H.8
-
40
-
-
10744230449
-
Correlation of Protein Expression and Gene Expression in Acute Leukemia
-
Kern W, Kohlmann A, Wuchter C, et al. Correlation of protein expression and gene expression in acute leukemia. Cytometry B Clin Cytom 2003; 55: 29-36. (Pubitemid 38295406)
-
(2003)
Cytometry Part B - Clinical Cytometry
, vol.55
, Issue.1
, pp. 29-36
-
-
Kern, W.1
Kohlmann, A.2
Wuchter, C.3
Schnittger, S.4
Schoch, C.5
Mergenthaler, S.6
Ratei, R.7
Ludwig, W.-D.8
Hiddemann, W.9
Haferlach, T.10
|