Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10

Molecular Endocrinology

Volumn 22, Issue 6, 2008, Pages 1357-1369

  Friesema, Edith C H ^a   Jansen, Jurgen ^a   Jachtenberg, Jan Willem ^a   Visser, W Edward ^a   Kester, Monique H A ^a   Visser, Theo J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CRYSTALLIN; IODIDE PEROXIDASE; IODOTHYRONINE; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 10; MONOCARBOXYLATE TRANSPORTER 8; MU CRYSTALLIN; PHENYLALANINE; THYROXINE; TRYPTOPHAN; TYPE 1 DEIODINASE; TYROSINE;

AFFINITY LABELING; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CELL STRAIN COS1; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEIODINATION; GENETIC TRANSFECTION; HORMONE TRANSPORT; IMMUNOBLOTTING; INCUBATION TIME; ISOTOPE LABELING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; EFFICIENCY; HUMANS; MOLECULAR SEQUENCE DATA; MONOCARBOXYLIC ACID TRANSPORTERS; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; THYROID HORMONES; TIME FACTORS; TRANSFECTION;

EID: 44649089035     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2007-0112     Document Type: Article

References (47)

1. Yen PM 2001 Physiological and molecular basis of thyroid hormone action. Physiol Rev 81:1097-1142
2. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
3. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ 2001 Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 22:451-476
4. Friesema EC, Jansen J, Milici C, Visser TJ 2005 Thyroid hormone transporters. Vitam Horm 70:137-167
5. Jansen J, Friesema EC, Milici C, Visser TJ 2005 Thyroid hormone transporters in health and disease. Thyroid 15:757-768
6. Zhou Y, Samson M, Francon J, Blondeau JP 1992 Thyroid hormone concentrative uptake in rat erythrocytes. Involvement of the tryptophan transport system T in countertransport of tri-iodothyronine and aromatic amino acids. Biochem J 281:81-86
7. Zhou Y, Samson M, Osty J, Francon J, Blondeau JP 1990 Evidence for a close link between the thyroid hormone transport system and the aromatic amino acid transport system T in erythrocytes. J Biol Chem 265:17000-17004
8. Kemp HF, Taylor PM 1997 Interactions between thyroid hormone and tryptophan transport in rat liver are modulated by thyroid status. Am J Physiol 272:E809-E816
9. 4) in the human choriocarcinoma cell line, JAR. J Endocrinol 167:487-492
10. Ritchie JW, Collingwood CJ, Taylor PM 2001 Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes. Am J Physiol Endocrinol Metab 280:E254-E259
11. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H 2001 Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 276:17221-17228
12. Kim do K, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H 2002 The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics 79:95-103
13. Blondeau JP, Beslin A, Chantoux F, Francon J 1993 Triiodothyronine is a high-affinity inhibitor of amino acid transport system L1 in cultured astrocytes. J Neurochem 60:1407-1413
14. Halestrap AP, Meredith D 2004 The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619-628
15. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128-40135
16. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH 2006 Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20:2761-2772
17. Allan W, Herndon CN, Dudley FC 1944 Some examples of the inheritance of mental deficiency: apparently sex-linked idiocy and microcephaly. Am J Mental Defic 48:325-334
18. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168-175
19. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437
20. Jansen J, Friesema EC, Kester MH, Milici C, Reeser M, Gruters A, Barrett TG, Mancilla EE, Svensson J, Wemeau ME, Hopper N, Arts WF, Visser TJ 2007 Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine. J Clin Endocrinol Metab 92:2378-2381
21. Maranduba CM, Friesema EC, Kok F, Kester MH, Jansen J, Sertie AL, Passos-Bueno MR, Visser TJ 2006 Decreased cellular uptake and metabolism in Allan-Herndon-Dudley syndrome (AHDS) due to a novel mutation in the MCT8 thyroid hormone transporter. J Med Genet 43:457-460
22. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE 2005 Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77:41-53
23. Kakinuma H, Itoh M, Takahashi H 2005 A novel mutation in the monocarboxylate transporter 8 gene in a boy with putamen lesions and low free T4 levels in cerebrospinal fluid. J Pediatr 147:552-554
24. Holden KR, Zuniga OF, May MM, Su H, Molinero MR, Rogers RC, Schwartz CE 2005 X-linked MCT8 gene mutations: characterization of the pediatric neurologic phenotype. J Child Neurol 20:852-857
25. Herzovich V, Vaiani E, Marino R, Dratler G, Lazzati JM, Tilitzky S, Ramirez P, Iorcansky S, Rivarola MA, Belgorosky A 2006 Unexpected peripheral markers of thyroid function in a patient with a novel mutation of the MCT8 thyroid hormone transporter gene. Horm Res 67:1-6
26. Namba N, Etani Y, Kitaoka T, Nakamoto Y, Nakacho M, Bessho K, Miyoshi Y, Mushiake S, Mohri I, Arai H, Taniike M, Ozono K 25 September 2007 Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter. Eur J Pediatr 10.1007/s00431-007-0589-6
27. Papadimitriou A, Dumitrescu AM, Papavasiliou A, Fretzayas A, Nicolaidou P, Refetoff S 2008 A novel monocarboxylate transporter 8 gene mutation as a cause of severe neonatal hypotonia and developmental delay. Pediatrics 121:e199-e202
28. Lafreniere RG, Carrel L, Willard HF 1994 A novel transmembrane transporter encoded by the XPCT gene in Xq13.2. Hum Mol Genet 3:1133-1139
29. Halestrap AP, Price NT 1999 The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343:281-299
30. Rechsteiner M, Rogers SW 1996 PEST sequences and regulation by proteolysis. Trends Biochem Sci 21:267-271
31. Vie MP, Evrard C, Osty J, Breton-Gilet A, Blanchet P, Pomerance M, Rouget P, Francon J, Blondeau JP 1997 Purification, molecular cloning, and functional expression of the human nicodinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein. Mol Endocrinol 11:1728-1736
32. 3-mediated transactivation. Endocrinology 143:1538-1544
33. Suzuki S, Mori J, Kobayashi M, Inagaki T, Inaba H, Komatsu A, Yamashita K, Takeda T, Miyamoto T, Ichikawa K, Hashizume K 2003 Cell-specific expression of NADPH-dependent cytosolic 3,5,3′-triiodo-L-thyronine-binding protein (p38CTBP). Eur J Endocrinol 148:259-268
34. Mol JA, Docter R, Kaptein E, Jansen G, Hennemann G, Visser TJ 1984 Inactivation and affinity-labeling of rat liver iodothyronine deiodinase with N-bromoacetyl-3,3′,5-triiodothyronine. Biochem Biophys Res Commun 124:475-483
35. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y 2004 CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch 447:532-542
36. Ramadan T, Camargo SM, Summa V, Hunziker P, Chesnov S, Pos KM, Verrey F 2006 Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway. J Cell Physiol 206:771-779
37. Ritchie JW, Shi YB, Hayashi Y, Baird FE, Muchekehu RW, Christie GR, Taylor PM 2003 A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors. Mol Endocrinol 17:653-661
38. Bernal J 2005 The significance of thyroid hormone transporters in the brain. Endocrinology 146:1698-1700
39. Bernal J 2005 Thyroid hormones and brain development. Vitam Horm 71:95-122
40. Heuer H, Maier MK, Iden S, Mittag J, Friesema EC, Visser TJ, Bauer K 2005 The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146:1701-1706
41. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ 2002 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 16:2283-2296
42. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, Sugiyama Y 2003 Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J Biol Chem 278:43489-43495
43. Tohyama K, Kusuhara H, Sugiyama Y 2004 Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology 145:4384-4391
44. Morreale de Escobar G, Obregon MJ, Escobar del Rey F 2000 Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 85:3975-3987
45. Huang SA, Dorfman DM, Genest DR, Salvatore D, Larsen PR 2003 Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab 88:1384-1388
46. Koopdonk-Kool JM, de Vijlder JJ, Veenboer GJ, Ris-Stalpers C, Kok JH, Vulsma T, Boer K, Visser TJ 1996 Type II and type III deiodinase activity in human placenta as a function of gestational age. J Clin Endocrinol Metab 81:2154-2158
47. Kuiper GG, Klootwijk W, Visser TJ 2003 Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference. Endocrinology 144:2505-2513