메뉴 건너뛰기




Volumn 11, Issue 7, 2009, Pages 923-935

Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program

Author keywords

Cell separation; Elutriation; Immunotherapy; Leukapheresis; Monocytes; T cells

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CELL SEPARATION; CELL SIZE; COMPUTER PROGRAM; COULTER COUNTER; COUNTER FLOW CENTRIFUGAL ELUTRIATION TECHNIQUE; DONOR; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKAPHERESIS; LYMPHOCYTE; LYMPHOCYTE DEPLETION; MONOCYTE; NEOPLASM; PRIORITY JOURNAL; SEPARATION TECHNIQUE;

EID: 70450180829     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653240903188921     Document Type: Article
Times cited : (45)

References (63)
  • 2
    • 34248149835 scopus 로고    scopus 로고
    • Principles of adoptive T cell cancer therapy
    • June CH. Principles of adoptive T cell cancer therapy. J Clin Invest 2007;117:1204-1212
    • (2007) J Clin Invest , vol.117 , pp. 1204-1212
    • June, C.H.1
  • 3
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T cell therapy for cancer in the clinic
    • June CH. Adoptive T cell therapy for cancer in the clinic. J Clin Invest 2007; 117:1466-1476
    • (2007) J Clin Invest , vol.117 , pp. 1466-1476
    • June, C.H.1
  • 4
    • 42149096101 scopus 로고    scopus 로고
    • T lymphocyte engineering ex vivo for cancer and infectious disease
    • Levine BL. T lymphocyte engineering ex vivo for cancer and infectious disease. Expert Opin Biol Ther 2008;8:475-489
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 475-489
    • Levine, B.L.1
  • 7
    • 10744233830 scopus 로고    scopus 로고
    • Molecular remission of CML after autotrans-plantation followed by adoptive transfer of costimulated autologous T cells
    • Rapoport AP, Levine BL,Badros A,Meisenberg B,Ruehle K, Nandi A, et al. Molecular remission of CML after autotrans-plantation followed by adoptive transfer of costimulated autologous T cells. Bone Marrow Transplant 2004;33:53-60.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 53-60
    • Rapoport, A.P.1    Levine, B.L.2    Badros, A.3    Meisenberg, B.4    Ruehle, K.5    Nandi, A.6
  • 8
    • 30744454570 scopus 로고    scopus 로고
    • Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
    • Rapoport AP, Stadtmauer EA, Aqui N, Badros A, Cotte J, Chrisley L, et al. Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med 2005;11:1230-1237
    • (2005) Nat Med , vol.11 , pp. 1230-1237
    • Rapoport, A.P.1    Stadtmauer, E.A.2    Aqui, N.3    Badros, A.4    Cotte, J.5    Chrisley, L.6
  • 9
    • 32644448488 scopus 로고    scopus 로고
    • A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
    • Porter DL, Levine BL, Bunin N, Stadtmauer EA, Luger SM, Goldstein S, et al. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood 2006;107:1325-1331
    • (2006) Blood , vol.107 , pp. 1325-1331
    • Porter, D.L.1    Levine, B.L.2    Bunin, N.3    Stadtmauer, E.A.4    Luger, S.M.5    Goldstein, S.6
  • 10
    • 34247559064 scopus 로고    scopus 로고
    • Inability to mediate prolonged reduction of regulatory T cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy
    • Powell DJ Jr, de Vries CR, Allen T, Ahmadzadeh M, Rosenberg SA. Inability to mediate prolonged reduction of regulatory T cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy. J Immunother 2007;30:438-447
    • (2007) J Immunother , vol.30 , pp. 438-447
    • Powell Jr., D.J.1    De Vries, C.R.2    Allen, T.3    Ahmadzadeh, M.4    Rosenberg, S.A.5
  • 14
    • 33750343038 scopus 로고    scopus 로고
    • Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion
    • Powell DJ Jr, Dudley ME, Hogan KA, Wunderlich JR, Rosenberg SA. Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion. J Immunol 2006;177:6527-6539
    • (2006) J Immunol , vol.177 , pp. 6527-6539
    • Powell Jr., D.J.1    Dudley, M.E.2    Hogan, K.A.3    Wunderlich, J.R.4    Rosenberg, S.A.5
  • 17
    • 18344406935 scopus 로고    scopus 로고
    • Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
    • Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, et al. Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 2000;96:467-474
    • (2000) Blood , vol.96 , pp. 467-474
    • Walker, R.E.1    Bechtel, C.M.2    Natarajan, V.3    Baseler, M.4    Hege, K.M.5    Metcalf, J.A.6
  • 18
    • 0035005380 scopus 로고    scopus 로고
    • Activation-induced T cell apoptosis by monocytes from stem cell products
    • Ino K,Ageitos AG, Singh RK,TalmadgeJE. Activation-induced T cell apoptosis by monocytes from stem cell products, hit Immunopharmacol 2001;1:1307-1319
    • (2001) Hit Immunopharmacol , vol.1 , pp. 1307-1319
    • Ino, K.1    Ageitos, A.G.2    Singh, R.K.3    Talmadge, J.E.4
  • 22
    • 34547809295 scopus 로고    scopus 로고
    • Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection
    • Erdmann M, Dorrie J, Schaft N, Strasser E, Hendelmeier M, Kampgen E, etal. Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection. J Immunother 2007;30:663-674
    • (2007) J Immunother , vol.30 , pp. 663-674
    • Erdmann, M.1    Dorrie, J.2    Schaft, N.3    Strasser, E.4    Hendelmeier, M.5    Kampgen, E.6
  • 23
    • 55249087908 scopus 로고    scopus 로고
    • Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors
    • Gulen D, Abe F, Maas S, Reed E, Cowan K, Pirruccello S, Wisecarver J, et al. Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors. Int Immunopharmacol 2008;8:1728-1736
    • (2008) Int Immunopharmacol , vol.8 , pp. 1728-1736
    • Gulen, D.1    Abe, F.2    Maas, S.3    Reed, E.4    Cowan, K.5    Pirruccello, S.6    Wisecarver, J.7
  • 24
    • 34547449658 scopus 로고    scopus 로고
    • A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines
    • Jarnjak-Jankovic S, Hammerstad H, Saeboe-Larssen S, Kvalheim G, Gaudernack G. A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines. BMC Cancer 2007;7:119.
    • (2007) BMC Cancer , vol.7 , pp. 119
    • Jarnjak-Jankovic, S.1    Hammerstad, H.2    Saeboe-Larssen, S.3    Kvalheim, G.4    Gaudernack, G.5
  • 25
    • 36349015333 scopus 로고    scopus 로고
    • Monocyte enrichment from leukapheresis products by using the Elutra cell separator
    • Kim S, Kim HO, Baek EJ, Choi Y, Kim HS, Lee MG. Monocyte enrichment from leukapheresis products by using the Elutra cell separator. Transfusion 2007;47:2290-2296
    • (2007) Transfusion , vol.47 , pp. 2290-2296
    • Kim, S.1    Kim, H.O.2    Baek, E.J.3    Choi, Y.4    Kim, H.S.5    Lee, M.G.6
  • 26
    • 33845888230 scopus 로고    scopus 로고
    • Purification of monocytes from cryopreserved mobilized apheresis products by elutriation with the Elutra device
    • Lemarie C, Sugaye R, Kaur I, Taga T, Chabannon C, Schuyler R, McMannis J. Purification of monocytes from cryopreserved mobilized apheresis products by elutriation with the Elutra device. J Immunol Methods 2007;318:30-36
    • (2007) J Immunol Methods , vol.318 , pp. 30-36
    • Lemarie, C.1    Sugaye, R.2    Kaur, I.3    Taga, T.4    Chabannon, C.5    Schuyler, R.6    McMannis, J.7
  • 27
    • 48249125852 scopus 로고    scopus 로고
    • Isolation of monocytes from leukapheretic products for large-scale GMP-grade generation of cytomegalovirus-specific T-cell lines by means of an automated elutriation device
    • Perseghin P, D'Amico G, Dander E, Gaipa G, Dassi M, Biagi E, Biondi A. Isolation of monocytes from leukapheretic products for large-scale GMP-grade generation of cytomegalovirus-specific T-cell lines by means of an automated elutriation device. Transfusion 2008;48:1644-1649
    • (2008) Transfusion , vol.48 , pp. 1644-1649
    • Perseghin, P.1    D'Amico, G.2    Dander, E.3    Gaipa, G.4    Dassi, M.5    Biagi, E.6    Biondi, A.7
  • 28
    • 0037106006 scopus 로고    scopus 로고
    • Large-scale monocyte enrichment coupled with a closed culture system for the generation of human dendritic cells
    • Pullarkat V, Lau R, Lee SM, Bender JG, Weber JS. Large-scale monocyte enrichment coupled with a closed culture system for the generation of human dendritic cells. J Immunol Methods 2002;267:173-183
    • (2002) J Immunol Methods , vol.267 , pp. 173-183
    • Pullarkat, V.1    Lau, R.2    Lee, S.M.3    Bender, J.G.4    Weber, J.S.5
  • 29
    • 0037390116 scopus 로고    scopus 로고
    • A closed and single-use system for monocyte enrichment: Potential for dendritic cell generation for clinical applications
    • Rouard H, Leon A, De Reys S, Taylor L, Logan J, Marquet J, et al. A closed and single-use system for monocyte enrichment: Potential for dendritic cell generation for clinical applications. Transfusion 2003;43:481-487
    • (2003) Transfusion , vol.43 , pp. 481-487
    • Rouard, H.1    Leon, A.2    De Reys, S.3    Taylor, L.4    Logan, J.5    Marquet, J.6
  • 31
    • 17744371122 scopus 로고    scopus 로고
    • Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy
    • Wong EC, Maher VE, Hines K, Lee J, Carter CS, Goletz T, et al. Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy. Cytotherapy 2001;3:19-29.
    • (2001) Cytotherapy , vol.3 , pp. 19-29
    • Wong, E.C.1    Maher, V.E.2    Hines, K.3    Lee, J.4    Carter, C.S.5    Goletz, T.6
  • 33
    • 58749089475 scopus 로고    scopus 로고
    • Combination of Cobe AutoPBSC and Gambro Elutra as a platform for monocyte enrichment in dendritic cell (DC) therapy: Clinical study
    • Chen Y, Hoecker P, Zeng J, Dettke M. Combination of Cobe AutoPBSC and Gambro Elutra as a platform for monocyte enrichment in dendritic cell (DC) therapy: Clinical study. J ClinApher 2008;23:157-162
    • (2008) J ClinApher , vol.23 , pp. 157-162
    • Chen, Y.1    Hoecker, P.2    Zeng, J.3    Dettke, M.4
  • 34
    • 0025863999 scopus 로고
    • Apheresis-elutriation program for adoptive immunotherapy with autologous activated monocytes in cancer patients
    • Faradji A, Bohbot A, Schmitt-Goguel M, Dumont S, Eischen A, Wiesel ML, et al. Apheresis-elutriation program for adoptive immunotherapy with autologous activated monocytes in cancer patients. Int J Artif Organs 1991;14:304-312
    • (1991) Int J Artif Organs , vol.14 , pp. 304-312
    • Faradji, A.1    Bohbot, A.2    Schmitt-Goguel, M.3    Dumont, S.4    Eischen, A.5    Wiesel, M.L.6
  • 36
    • 0018636075 scopus 로고
    • Comparison of lymphocyte function after isolation by ficoll-hypaque flotation or elutriation
    • Berger CL, Edelson RL. Comparison of lymphocyte function after isolation by ficoll-hypaque flotation or elutriation. J Invest Dermatol 1979;73:23 1-5.
    • (1979) J Invest Dermatol , vol.73 , Issue.23 , pp. 1-5
    • Berger, C.L.1    Edelson, R.L.2
  • 38
    • 0032954544 scopus 로고    scopus 로고
    • The role of autologous hematopoietic progenitor and cell reinfusion for intensive chemotherapy in women with poor-prognosis breast cancer. Clinical studies with ex-vivo expanded cells produced with the Aastrom Rep-licell technology
    • Chabannon C, Novakovitch G, Blache JL, Olivero S, Camerlo J, Genre D, et al. The role of autologous hematopoietic progenitor and cell reinfusion for intensive chemotherapy in women with poor-prognosis breast cancer. Clinical studies with ex-vivo expanded cells produced with the Aastrom Rep-licell technology. Hematol Cell Ther 1999;41:78-81.
    • (1999) Hematol Cell Ther , vol.41 , pp. 78-81
    • Chabannon, C.1    Novakovitch, G.2    Blache, J.L.3    Olivero, S.4    Camerlo, J.5    Genre, D.6
  • 39
    • 10744222172 scopus 로고    scopus 로고
    • Augmentation of umbilical cord blood (UCB) transplantation with ex two-expanded UCB cells: Results of a phase 1 trial using the AastromReplicell system
    • Jaroscak J, Goltry K, Smith A, Waters-Pick B, Martin PL, Driscoll TA, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex two-expanded UCB cells: Results of a phase 1 trial using the AastromReplicell system. Blood 2003;101:5061-5067
    • (2003) Blood , vol.101 , pp. 5061-5067
    • Jaroscak, J.1    Goltry, K.2    Smith, A.3    Waters-Pick, B.4    Martin, P.L.5    Driscoll, T.A.6
  • 40
    • 0141456489 scopus 로고    scopus 로고
    • A phase i trial of CD3/CD28-activated T cells (Xcellerated T cells) and interleukin-2 in patients with metastatic renal cell carcinoma
    • Thompson JA, Figlin RA, Sifri-Steele C, Berenson RJ, Frohlich MW A phase I trial of CD3/CD28-activated T cells (Xcellerated T cells) and interleukin-2 in patients with metastatic renal cell carcinoma. Clin Cancer Res 2003;9:3562-3570
    • (2003) Clin Cancer Res , vol.9 , pp. 3562-3570
    • Thompson, J.A.1    Figlin, R.A.2    Sifri-Steele, C.3    Berenson, R.J.4    Frohlich, M.W.5
  • 41
    • 0037880380 scopus 로고    scopus 로고
    • + monocytes positively selected by immunomagnetic adsorption for multiple myeloma patients enrolled in a clinical trial of anti-idiotype vaccination
    • + monocytes positively selected by immunomagnetic adsorption for multiple myeloma patients enrolled in a clinical trial of anti-idiotype vaccination. Br J Haematol 2003; 121:240-250
    • (2003) Br J Haematol , vol.121 , pp. 240-250
    • Motta, M.R.1    Castellani, S.2    Rizzi, S.3    Curti, A.4    Gubinelli, F.5    Fogli, M.6
  • 43
    • 12144287162 scopus 로고    scopus 로고
    • A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation
    • Barfield RC, Otto M, Houston J, Holladay M, Geiger T, Martin J, et al. A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy 2004;6:1-6.
    • (2004) Cytotherapy , vol.6 , pp. 1-6
    • Barfield, R.C.1    Otto, M.2    Houston, J.3    Holladay, M.4    Geiger, T.5    Martin, J.6
  • 44
    • 85031343514 scopus 로고    scopus 로고
    • Design and implementation of VRX496 phase II cell processing for cGMP production of multiple doses of lentivirally transduced autologous HIV infected CD4 + T lymphocytes
    • Humeau L, Cohen R, Encinas T, Skripchenko Y, Lemiale F, Andre K, et al. Design and implementation of VRX496 phase II cell processing for cGMP production of multiple doses of lentivirally transduced autologous HIV infected CD4 + T lymphocytes. Molecular Therapy 2006;S427.
    • (2006) Molecular Therapy
    • Humeau, L.1    Cohen, R.2    Encinas, T.3    Skripchenko, Y.4    Lemiale, F.5    Andre, K.6
  • 45
    • 52049118092 scopus 로고    scopus 로고
    • Clinical grade Treg: GMP isolation, improvement of purity by CD 127 depletion, Treg expansion, and Treg cryopreservation
    • Peters JH, Preijers FW, Woestenenk R, Hilbrands LB, Koenen HJ, Joosten I. Clinical grade Treg: GMP isolation, improvement of purity by CD 127 depletion, Treg expansion, and Treg cryopreservation. PLoS ONE 2008;3:e3161.
    • (2008) PLoS ONE , vol.3
    • Peters, J.H.1    Preijers, F.W.2    Woestenenk, R.3    Hilbrands, L.B.4    Koenen, H.J.5    Joosten, I.6
  • 46
    • 21844471006 scopus 로고    scopus 로고
    • Large-scale depletion of CD25+ regulatory T cells from patient leuka-pheresis samples
    • Powell DJ Jr, Parker LL, Rosenberg SA. Large-scale depletion of CD25+ regulatory T cells from patient leuka-pheresis samples. JImmunother 2005;28:403-411
    • (2005) J Immunother , vol.28 , pp. 403-411
    • Powell Jr., D.J.1    Parker, L.L.2    Rosenberg, S.A.3
  • 47
    • 56049112370 scopus 로고    scopus 로고
    • high reguiatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell transfer therapy
    • high reguiatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell transfer therapy. Cytotherapy 2008;10:698-710.
    • (2008) Cytotherapy , vol.10 , pp. 698-710
    • Sumida, Y.1    Nakamura, K.2    Kanayama, K.3    Akiho, H.4    Teshima, T.5    Takayanagi, R.6
  • 49
    • 0022352684 scopus 로고
    • Perturbation of the T4 molecule transmits a negative signal to T cells
    • Bank I, Chess L. Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med 1985;162:1294-1303
    • (1985) J Exp Med , vol.162 , pp. 1294-1303
    • Bank, I.1    Chess, L.2
  • 52
    • 0036644272 scopus 로고    scopus 로고
    • A therapeutic CD4 monoclonal antibody inhibits TCR-zeta chain phosphorylation, zeta-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells
    • Harding S, Lipp P, Alexander DR. A therapeutic CD4 monoclonal antibody inhibits TCR-zeta chain phosphorylation, zeta-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells. J Immunol 2002;169:230-238
    • (2002) J Immunol , vol.169 , pp. 230-238
    • Harding, S.1    Lipp, P.2    Alexander, D.R.3
  • 53
    • 0026647524 scopus 로고
    • Association of tyrosine kinase p561ck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor
    • Haughn L, Gratton S, Caron L, Sekaly RP, Veillette A, Julius M. Association of tyrosine kinase p561ck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor. Nature 1992;358:328-331
    • (1992) Nature , vol.358 , pp. 328-331
    • Haughn, L.1    Gratton, S.2    Caron, L.3    Sekaly, R.P.4    Veillette, A.5    Julius, M.6
  • 54
    • 0030636724 scopus 로고    scopus 로고
    • CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation
    • Jabado N, Pallier A, Le Deist F, Bernard F, Fischer A, Hivroz C. CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J Immunol 1997;158:94-103.
    • (1997) J Immunol , vol.158 , pp. 94-103
    • Jabado, N.1    Pallier, A.2    Le Deist, F.3    Bernard, F.4    Fischer, A.5    Hivroz, C.6
  • 55
    • 0025085508 scopus 로고
    • Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen
    • Newell MK, Haughn LJ, Maroun CR, Julius MH. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 1990;347:286-289
    • (1990) Nature , vol.347 , pp. 286-289
    • Newell, M.K.1    Haughn, L.J.2    Maroun, C.R.3    Julius, M.H.4
  • 56
    • 0030030971 scopus 로고    scopus 로고
    • IL-2-resistant hyporesponsiveness induced by CD4 mAbs in OKT3-activated human T cells is reversed by CD45RA triggering
    • Robinet E, Fournel S, Fatmi A, Revillard JR IL-2-resistant hyporesponsiveness induced by CD4 mAbs in OKT3-activated human T cells is reversed by CD45RA triggering. Cell Immunol 1996;167:1-7.
    • (1996) Cell Immunol , vol.167 , pp. 1-7
    • Robinet, E.1    Fournel, S.2    Fatmi, A.3    Revillard, J.R.4
  • 57
    • 0032077566 scopus 로고    scopus 로고
    • A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69
    • Woods M, Guy R, Waldmann H, Glennie M, Alexander DR. A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69. Celllmmunol 1998;185:101-113
    • (1998) Celllmmunol , vol.185 , pp. 101-113
    • Woods, M.1    Guy, R.2    Waldmann, H.3    Glennie, M.4    Alexander, D.R.5
  • 59
    • 11144241310 scopus 로고    scopus 로고
    • + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
    • + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy. Blood 2005;105:241-250
    • (2005) Blood , vol.105 , pp. 241-250
    • Powell Jr., D.J.1    Dudley, M.E.2    Robbins, P.F.3    Rosenberg, S.A.4
  • 61
    • 11344251911 scopus 로고    scopus 로고
    • Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy
    • Zhou J, Dudley ME, Rosenberg SA, Robbins PF. Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy. J Immunother 2005;28:53-62.
    • (2005) J Immunother , vol.28 , pp. 53-62
    • Zhou, J.1    Dudley, M.E.2    Rosenberg, S.A.3    Robbins, P.F.4
  • 62
    • 27744450650 scopus 로고    scopus 로고
    • Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy
    • Zhou J, Shen X, Huang J, Hodes RJ, Rosenberg SA, Robbins PF. Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J Immunol 2005; 175:7046-7052
    • (2005) J Immunol , vol.175 , pp. 7046-7052
    • Zhou, J.1    Shen, X.2    Huang, J.3    Hodes, R.J.4    Rosenberg, S.A.5    Robbins, P.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.