Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy

Cytotherapy

Volumn 3, Issue 1, 2001, Pages 19-29

  Wong, E C C ^a   Maher, V E ^b   Hines, K ^a   Lee, J ^a   Carter, C S ^a   Goletz, T ^b   Kopp, W ^c   Mackall, C L ^b   Berzofsky, J A ^b   Read, E J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Dendritic cells (DCs); Immunotherapy; Peripheral blood monocytes

Indexed keywords

B7 ANTIGEN; CARBON DIOXIDE; CD1 ANTIGEN; CD14 ANTIGEN; CD83 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; TETANUS TOXOID; GLUCOSE; LACTIC ACID;

ARTICLE; BIOMEDICAL ENGINEERING; BLOOD GROUP TYPING; CANCER IMMUNOTHERAPY; CANCER PATIENT; CELL FUNCTION; CELL ISOLATION; CELL STRUCTURE; CELL VIABILITY; CELLULAR PARAMETERS; CENTRIFUGATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUNTERCURRENT FLOW; CULTURE MEDIUM; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLUENZA VIRUS; LEUKAPHERESIS; LEUKOCYTE CULTURE; MONOCYTE; PEDIATRICS; PHENOTYPE; PLASMA; PURIFICATION; SARCOMA; TIME; AUTOTRANSPLANTATION; BIOLOGICAL THERAPY; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL SIZE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; METHODOLOGY; PH; TRANSPLANTATION;

CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL SIZE; CELL SURVIVAL; CLINICAL TRIALS; CULTURE MEDIA; DENDRITIC CELLS; FLOW CYTOMETRY; GLUCOSE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMAN; HYDROGEN-ION CONCENTRATION; IMMUNOTHERAPY; INTERLEUKIN-4; LACTIC ACID; LEUKAPHERESIS; MONOCYTES; SARCOMA; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TISSUE THERAPY; TRANSPLANTATION, AUTOLOGOUS;

EID: 17744371122     PISSN: 14653249     EISSN: None     Source Type: Journal    
DOI: 10.1080/146532401753156377     Document Type: Article

References (19)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
2. Dubois B, Barthelemy C, Durand I. Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching. J Immunol 1999;162: 3428-36.
3. Tang HL, Cyster JG. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science 1999;284:819-22.
4. Timmerman JM, Levy R. Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med 1999;50:507-29.
5. Romani N, Reider D, Heuer M et al. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 1996;196:137-51.
6. Bender A, Sapp G, Shuler G et al. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996;196:121-35.
7. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994;179:1109-18.
8. Czerniecki BJ, Carter C, Rivoltini L et al. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells. J Immunol 1997;159:3823-37.
9. Bernard J, Ittelet D, Christoph A et al. Adherent-free generation of functional dendritic cells from purified blood monocytes in view of potential use. Hematol Cell Ther 1998;40:17-26.
10. + hematopoietic progenitor cells. Immunobiology 1998;198:501-13.
11. Thurner B, Roder C, Dieckmann D et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods 1999;223:1-15.
12. Macy E, Bulpitt K, Champlin RE et al. Anaphylaxis to infusion of autologous bone marrow: an apparent reaction to self, mediated by IgE antibody to bovine serum albumin. J Allergy Clin Immunol 1989;83:871-5.
13. Selvaggi TA, Walker RE, Fleisher TA. Development of antibodies to fetal calf serum with Arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions. Blood 1997;89:776-9.
14. Eljaafari A, Duperrier K, Mazet S et al. Generation of stable monocyte-derived dendritic cells in the presence of high concentrations of homologous or autologous serum: influence of extra-cellular pH. Human Immunol 1998;59:625-34.
15. + T cells resulting in a failure to lyse tumor cells. Blood 1999;93:1634-42.
16. Gabrilovich DI, Chen HL, Girgis KR et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nature Med 1996;10:1096-103.
17. Morse, MA, Lyerly HK, Gilboa E et al. Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. Cancer Res 1998;58: 2965-8.
18. + dendritic cells. Proc Natl Acad Sci USA 1996;93:2588-92.
19. + cells in gas-permeable containers under serum-free conditions. J Hematother 1998;7:403-11.