Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

BJU International

Volumn 101, Issue 6, 2008, Pages 758-764

  Yildiz, Esin ^a   Ayan, Semih ^a,b   Goze, Fahrettin ^a   Gokce, Gokhan ^a   Gultekin, Emin Y ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b Cumhuriyet University Hospital Campus   (Turkey)

Author keywords

Microvascular density; Microvascular invasion; Prognosis; Renal cell carcinoma

Indexed keywords

ALPHA INTERFERON; FORMALDEHYDE;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CLINICAL EVALUATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DENSITY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROVASCULATURE METASTASIS; MICROVESSEL DENSITY; MONOTHERAPY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TUMOR VOLUME; UNIVARIATE ANALYSIS;

ADULT; AGED; CARCINOMA, RENAL CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; MICROCIRCULATION; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; NEPHRECTOMY; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 39449110749     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2007.07318.x     Document Type: Article

References (21)

1. Imao T, Egawa M, Takashima H, Koshida K, Mamiki M. Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma. Int J Urol 2004 11 : 948 53
2. Yoshino S, Kato M, Okada K. Prognostic significance of microvessel count in low stage renal cell carcinoma. Int J Urol 1995 2 : 156 60
3. Paradis V, Lagha NB, Zeimoura NL et al. Expression of vascular endothelial growth factor in renal cell carcinomas. Virchows Arch 2000 436 : 351 6
4. MacLennan MD, Bostwick MD. Microvessel density in renal cell carcinoma: lack of prognostic significance. Urology 1995 46 : 27 30
5. Suzuki K, Morita T, Hashimoto S, Tokue A. Thymidine phosphorylase/ platelet-derived cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma. Urol Res 2001 29 : 7 12
6. Slaton JW, Inoue K, Perrotte P et al. Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol 2001 158 : 735 43
7. Delahunt B, Bethwaite PB, Thornton A. Prognostic significance of microscopic vascularity for clear cell renal carcinoma. Br J Urol 1997 80 : 401 4
8. Rioux-Leclercq N, Epstein JL, Bansard JY et al. Clinical significance of cell proliferation, microvessel density, and CD44 adhesion molecule expression in renal cell carcinoma. Hum Pathol 2001 32 : 1209 15
9. Sabo E, Boltenko A, Sova Y, Stein A, Kleinhaus S, Restnick MB. Microscopic analysis and significance of vascular architectural complexity in renal cell carcinoma. Clin Cancer Res 2001 7 : 533 7
10. Kohler HH, Barth PJ, Siebel A, Gerharz EW, Bittinger A. Quantitative assessment of vascular surface density in renal cell carcinomas. Br J Urol 1996 77 : 650 4
11. Hemmerlein B, Kugler A, Ozisik R, Ringert RH, Radzun HJ, Thelen P. Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas. Virchows Arch 2001 439 : 645 52
12. Dekel Y, Koren R, Kugel V, Livne PM, Gal R. Significance of angiogenesis and microvascular invasion in renal cell carcinoma. Pathol Oncol Res 2002 8 : 129 32
13. Yildiz E, Gokce G, Kilicarslan H, Ayan S, Goze OF, Gultekin EY. Prognostic value of the expression of Ki-67, CD44 and vascular endothelial growth factor, and microvessel invasion, in renal cell carcinoma. BJU Int 2004 93 : 1087 93
14. Griffiths DF, Verghese A, Golash A et al. Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma. BJU Int 2002 90 : 26 31
15. Schlingemann RO, Rielveld FJR, Waal RMW et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microproccesses in the tumor stroma. Lab Invest 1990 62 : 690 6
16. Samma S, Yoshida K, Osono S et al. Tumor thrombus and microvascular invasion as prognostic factor in renal cell carcinoma. Jpn J Clin Oncol 1991 21 : 340 5
17. Nelson EC, Evans CP, Lara PN Jr. Renal cell carcinoma: current status and emerging therapies. Cancer Treat Rev 2007 33 : 299 13
18. Mrstik C, Salamon J, Weber R, Stogermayer F. Microscopic venous infiltration as predictor of relapse in renal cell carcinoma. J Urol 1992 148 : 271 4
19. Herbst C, Kosmehl H, Stiller KJ et al. Evaluation of microvessel density by computerized image analysis in human renal cell carcinoma. J Cancer Res Clin Oncol 1998 124 : 141 7
20. Nagy JA, Brown LF, Senger DR. Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophs Acta 1989 948 : 305 26
21. Gross JL, Moscatelli D, Jaffe EA, Rifkin DB. Plasminogen activator and collagenase production by cultured capillary endothelial cells. J Cell Biol 1982 95 : 974 81