Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells

Biochemical Society Transactions

Volumn 37, Issue 6, 2009, Pages 1179-1183

  Wheeler Jones, Caroline P D ^a   Farrar, Charlotte ^a   Garonna, Elena ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Angiogenesis; Arachidonic acid; Cyclo oxygenase (COX); Endothelial cell; Prostanoid; Protease activated receptor (PAR)

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN SYNTHASE; PROSTANOID; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN;

ANGIOGENESIS; ARTICLE; AUTOCRINE EFFECT; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; INFLAMMATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; EPOPROSTENOL; HUMANS; INFLAMMATION; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PROSTAGLANDINS; PROTEIN ISOFORMS; RECEPTORS, PROTEINASE-ACTIVATED; SIGNAL TRANSDUCTION;

EID: 70450160138     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0371179     Document Type: Article

References (40)

1. Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I. and Murakami, M. (2005) Coupling between cyclooxygenases and terminal prostanoid synthases. Biochem. Biophys. Res. Commun. 338, 70-76
2. Houliston, R.A., Keogh, R.J., Sugden, D., Dudhia, J., Carter, T.D. and Wheeler-Jones, C.P.D. (2002) Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells. Thromb. Haemostasis 88, 321-328
3. Syeda, F., Grosjean, J., Houliston, R.A., Carter, T., Paleolog, E. and Wheeler-Jones, C.P.D. (2006) Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells requires co-operation between mitogen-activated protein kinase and NF-κB pathways. J. Biol. Chem. 281, 11792-11804
4. Wheeler-Jones, C.P.D., Abu-Ghazaleh, R., Cospedal, R., Houliston, R.A., Martin, J. and Zachary, I. (1997) Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett. 420, 28-32
5. 2 synthesis in endothelium. Am. J. Physiol. Cell Physiol. 281, C1266-C1276
6. 2-biosynthetic pathway. Prog. Lipid Res. 43, 3-35
7. Grosser, T., Fries, S. and Fitzgerald, G.A. (2006) Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J. Clin. Invest. 116, 4-15
8. Rudic, R.D., Brinste, D., Cheng, Y., Fries, S., Song, W.L., Austin, S., Coffman, T.M. and Fitzgerald, G.A. (2005) COX-2-derived prostacyclin modulates vascular remodeling. Circ. Res. 96, 1240-1247
9. Lovgren, A.K., Jania, L.A., Hartney, J.M., Parsons, K.K., Audoly, L.P., Fitzgerald, G.A., Tilley, S.L. and Koller, B.H. (2006) COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L144-L156
10. Liou, J.Y., Matijevic-Aleksic, N., Lee, S. and Wu, K.K. (2007) Prostacyclin inhibits endothelial cell XIAP ubiquitination and degradation. J. Cell. Physiol. 212, 840-848
11. Bundey, R.A. and Insel, P.A. (2006) Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Mol. Pharmacol. 70, 1700-1707
12. Ng, Y.V., Huang, Y., Reddy, L.M., Falck, J.R., Lin, E.T. and Kroetz, D.L. (2007) Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor α. Drug Metab. Dispos. 35, 1126-1134
13. Macfarlane, S.R., Seatter, M.J., Kanke, T., Hunter, G.D. and Plevin, R. (2001) Proteinase-activated receptors. Pharmacol. Rev. 53, 245-282
14. Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G.S., Bunnett, N.W. et al. (2006) Proteinase-activated receptors: targets for kallikrein signaling. J. Biol. Chem. 281, 32095-32112
15. Blackburn, J.S. and Brinckerhoff, C.E. (2008) Matrix metalloproteinase- 1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. Am. J. Pathol. 173, 1736-1746
16. Ritchie, E., Saka, M., MacKenzie, C., Drummond, R., Wheeler-Jones, C.P.D., Kanke, T. and Plevin, R. (2007) Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory κB kinase β in human endothelial cells. Br. J. Pharmacol. 150, 1044-1054
17. Gudmundsdottir, I.J., Megson, I.L., Kell, J.S., Ludlam, C.A., Fox, K.A.A., Webb, D.J. and Newby, D.E. (2006) Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation 114, 1625-1632
18. Robin, J., Kharbanda, R., Mclean, P., Campbell, R. and Vallance, P. (2003) Protease-activated receptor-2-mediated vasodilatation in humans in vivo: role of nitric oxide and prostanoids. Circulation 107, 954-959
19. Ahamed, J. and Ruf, W. (2004) Protease-activated receptor-2-dependent phosphorylation of the tissue factor cytoplasmic domain. J. Biol. Chem. 279, 23038-23044
20. Klarenbach, S.W., Chipiuk, A., Nelson, R.C., Hollenberg, M,D. and Murray, A.G. (2003) Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. Circ. Res. 92, 272-278
21. Matsumoto, H., Ma, W.G., Daikoku, T., Zhao, X., Paria, B.C., Das, S.K., Trzaskos, J.M. and Dey, S.K. (2002) Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice. J. Biol. Chem. 277, 29260-29267
22. Ohashi, K., Ouchi, N., Sato, K., Higuchi, A., Ishikawa, T.O., Herschman, H.R., Kihara, S. and Walsh, K. (2009) Adiponectin promotes revascularization of ischemic muscle a through a cyclooxygenase 2-dependent mechanism. Mol. Cell. Biol. 29, 3487-3499
23. Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M. and DuBois, R.N. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. 93, 705-716
24. Caunt, M., Huang, Y., Brooks, P. and Karpatkin, S. (2003) Thrombin induces neoagiogenesis in the chick chorioallantoic membrane. J. Thromb. Haemostasis 1, 2097-2102
25. Milia, A.F., Salis, M.B., Stacca, T., Pinna, A., Madeddu, P., Trevisani, M., Geppetti, P. and Emanueli, C. (2002) Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischaemia. Circ. Res. 91, 346-352
26. Zhu, T., Sennlaub, F., Beauchamp, M.H., Fan, L., Joyal, J.S., Checcin, D., Nim, S., Lachapelle, P., Sirinyan, M., Hou, X. et al. (2006) Pro-angiogenic effects of protease-activated receptor 2 are tumor necrosis factor-α and consecutively Tie2 dependent. Arterioscler. Thromb. Vasc. Biol. 26, 744-750
27. Simeone, A.M., Nieves-Alicea, R., McMurtry, V.C., Colella, S., Krahe, R. and Tar, A.M. (2007) Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. Int. J. Oncol. 30, 785-792
28. 2α as a novel mechanism regulating endothelial cell cycle progression and angiogenesis. J. Biol. Chem. 284, 5784-5796
29. Clarkin, C.E., Emery, R.J., Pitsillides, A.A. and Wheeler-Jones, C.P.D. (2008) Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. J. Cell. Physiol. 214, 537-544
30. Clarkin, C.E., Garonna, E., Pitsillides, A.A. and Wheeler-Jones, C.P.D. (2008) Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: a negative modulatory role for prostanoids in VEGF-mediated cell:cell communication? Exp. Cell Res. 314, 3152-3161
31. Zhu, T., Sennlaub, F., Beauchamp, M.H., Fan, L., Joyal, J.S., Checchin, D., Nim, S., Lachapelle, P., Sirinyan, M., Hou, X. et al. (2006) Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-α and consecutively Tie2 dependent. Arterioscler. Thromb. Vasc. Biol. 26, 744-750
32. Numaguchi, Y., Naruse, K., Harada, M., Osanai, H., Mokuno, S., Murase, K., Matsui, H., Toki, Y., Ito, T., Okumura, K. and Hayakawa, T. (1999) Prostacyclin synthase gene transfer accelerates reendothelialisation and inhibits neointimal formation in rat carotid arteries after balloon injury. Arterioscler. Thromb. Vasc. Biol. 19, 727-733
33. Hiraoka, K., Koike, H., Yamamoto, S., Tomita, N., Yokoyama, C., Tanabe, T., Aikou, T., Ogihara, T., Kaneda, Y. and Morishita, R. (2003) Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Circulation 108, 2689-2696
34. Liou, J.Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N. and Wu, K.K. (2007) Protection of endothelial cell survival by peroxisome proliferatoractivated receptor (δ) mediated 14-3-3 upregulation. Arterioscler. Thromb. Vasc. Biol. 26, 1481-1487
35. Wise, H. (2003) Multiple signaling options for prostacyclin. Acta Pharmacol. Sin. 24, 625-630
36. Wheeler-Jones, C.P.D. (2008) Regulation of endothelial prostacyclin synthesis by protease-activated receptors: mechanisms and significance. Pharmacol. Rep. 60, 109-118
37. George, R.J., Sturmoski, M.A., Anant, S. and Houcvhen, C.W. (2007) EP4 mediates PGE2-dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat. 83, 112-120
38. Wheeler-Jones, C.P.D. (2005) Signalling in the cardiovascular system: an overview. Heart 91, 1366-1374
39. Darmoul, D., Gratso, V., Devand, H. and Laburthe, M. (2004) Protease-activated receptor-2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J. Biol. Chem. 279, 20927-20934
40. Cao, H., Dronadula, N. and Rao, G.N. (2007) Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 290, C172-C182