메뉴 건너뛰기




Volumn 57, Issue 11, 2009, Pages 1087-1097

Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation

Author keywords

Angiogenesis; NSCLC; Proliferation; Thymidine kinase 1; Thymidine phosphorylase

Indexed keywords

CD31 ANTIGEN; KI 67 ANTIGEN; THYMIDINE; THYMIDINE KINASE 1; THYMIDINE PHOSPHORYLASE; THYMIDINE KINASE;

EID: 70449732675     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.2009.952804     Document Type: Article
Times cited : (26)

References (91)
  • 2
    • 0032529047 scopus 로고    scopus 로고
    • Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis
    • Brown NS, Bicknell R (1998) Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis. Biochem J 334:1-8
    • (1998) Biochem J , vol.334 , pp. 1-8
    • Brown, N.S.1    Bicknell, R.2
  • 3
    • 84959829882 scopus 로고
    • Method for the quantitative morphological analysis of tissues
    • Chalkley H (1943) Method for the quantitative morphological analysis of tissues. J Natl Cancer Inst 4:47-53
    • (1943) J Natl Cancer Inst , vol.4 , pp. 47-53
    • Chalkley, H.1
  • 4
    • 37349005979 scopus 로고    scopus 로고
    • Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues
    • Chujo M, Miura T, Kawano Y, Miyawaki M, Imakiire T, Hayashita Y, Kawahara K (2006) Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues. Oncol Rep 16:777-780
    • (2006) Oncol Rep , vol.16 , pp. 777-780
    • Chujo, M.1    Miura, T.2    Kawano, Y.3    Miyawaki, M.4    Imakiire, T.5    Hayashita, Y.6    Kawahara, K.7
  • 5
    • 0025012042 scopus 로고
    • Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells
    • Cotter TG, Lennon SV, Glynn JG, Martin SJ (1990) Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells. Anticancer Res 10:1153-1159
    • (1990) Anticancer Res , vol.10 , pp. 1153-1159
    • Cotter, T.G.1    Lennon, S.V.2    Glynn, J.G.3    Martin, S.J.4
  • 6
    • 4544363241 scopus 로고    scopus 로고
    • The changes of gene expression profiles in hydatidiform mole and choriocarcinoma with hyperplasia of trophoblasts
    • Cui JQ, Shi YF, Zhou HJ, Li JQ (2004) The changes of gene expression profiles in hydatidiform mole and choriocarcinoma with hyperplasia of trophoblasts. Int J Gynecol Cancer 14:984-997
    • (2004) Int J Gynecol Cancer , vol.14 , pp. 984-997
    • Cui, J.Q.1    Shi, Y.F.2    Zhou, H.J.3    Li, J.Q.4
  • 7
    • 0037436280 scopus 로고    scopus 로고
    • Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells
    • de Bruin M, Smid K, Laan AC, Noordhuis P, Fukushima M, Hoekman K, Pinedo HM, et al. (2003) Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells. Biochem Biophys Res Commun 301:675-679
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 675-679
    • de Bruin, M.1    Smid, K.2    Laan, A.C.3    Noordhuis, P.4    Fukushima, M.5    Hoekman, K.6    Pinedo, H.M.7
  • 8
    • 0022507166 scopus 로고
    • Cellular heterogeneity in lung cancer
    • Dunnill MS, Gatter KC (1986) Cellular heterogeneity in lung cancer. Histopathology 10:461-475
    • (1986) Histopathology , vol.10 , pp. 461-475
    • Dunnill, M.S.1    Gatter, K.C.2
  • 9
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies
    • Eberhard A, Kahlert S, Goede V, Hemmerlein B, Plate KH, Augustin HG (2000) Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res 60:1388-1393
    • (2000) Cancer Res , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 10
    • 0141988568 scopus 로고    scopus 로고
    • Fundamental concepts of the angiogenic process
    • Folkman J (2003) Fundamental concepts of the angiogenic process. Curr Mol Med 3:643-651
    • (2003) Curr Mol Med , vol.3 , pp. 643-651
    • Folkman, J.1
  • 11
    • 0028281416 scopus 로고
    • Tumor angiogenesis in node-negative breast carcinomas: Relationship with epidermal growth factor receptor, estrogen receptor, and survival
    • Fox SB, Leek RD, Smith K, Hollyer J, Greenall M, Harris AL (1994) Tumor angiogenesis in node-negative breast carcinomas: relationship with epidermal growth factor receptor, estrogen receptor, and survival. Breast Cancer Res Treat 29:109-116
    • (1994) Breast Cancer Res Treat , vol.29 , pp. 109-116
    • Fox, S.B.1    Leek, R.D.2    Smith, K.3    Hollyer, J.4    Greenall, M.5    Harris, A.L.6
  • 12
    • 0028822945 scopus 로고
    • Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count, and computer image analysis
    • Fox SB, Leek RD, Smith K, Hollyer J, Greenall M, Harris AL (1995a) Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 177:275-283
    • (1995) J Pathol , vol.177 , pp. 275-283
    • Fox, S.B.1    Leek, R.D.2    Smith, K.3    Hollyer, J.4    Greenall, M.5    Harris, A.L.6
  • 13
    • 0029006332 scopus 로고
    • Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: An immunohistochemical study
    • Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL (1995b) Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 176:183-190
    • (1995) J Pathol , vol.176 , pp. 183-190
    • Fox, S.B.1    Moghaddam, A.2    Westwood, M.3    Turley, H.4    Bicknell, R.5    Gatter, K.C.6    Harris, A.L.7
  • 19
    • 0034128022 scopus 로고    scopus 로고
    • Radiosynthesis of 3′-deoxy-3′- [(18) F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo
    • Grierson JR, Shields AF (2000) Radiosynthesis of 3′-deoxy-3′- [(18) F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo. Nucl Med Biol 27:143-156
    • (2000) Nucl Med Biol , vol.27 , pp. 143-156
    • Grierson, J.R.1    Shields, A.F.2
  • 21
    • 0028318194 scopus 로고
    • Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells
    • Hengstschlager M, Knofler M, Mullner EW, Ogris E, Wintersberger E, Wawra E (1994a) Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells. J Biol Chem 269:13836-13842
    • (1994) J Biol Chem , vol.269 , pp. 13836-13842
    • Hengstschlager, M.1    Knofler, M.2    Mullner, E.W.3    Ogris, E.4    Wintersberger, E.5    Wawra, E.6
  • 22
    • 0028080421 scopus 로고
    • A common regulation of genes encoding enzymes of the deoxy-nucleotide metabolism is lost after neoplastic transformation
    • Hengstschlager M, Mudrak I, Wintersberger E, Wawra E (1994b) A common regulation of genes encoding enzymes of the deoxy-nucleotide metabolism is lost after neoplastic transformation. Cell Growth Differ 5:1389-1394
    • (1994) Cell Growth Differ , vol.5 , pp. 1389-1394
    • Hengstschlager, M.1    Mudrak, I.2    Wintersberger, E.3    Wawra, E.4
  • 23
    • 0037246688 scopus 로고    scopus 로고
    • Thymidine phosphorylase and dihydropyrimidine dehydrogenase in renal cell carcinoma: Relationship between histological parameters and chemosensitivity to 5-fluorouracil
    • Hirano Y, Takayama T, Kageyama S, Ushiyama T, Suzuki K, Fujita K (2003) Thymidine phosphorylase and dihydropyrimidine dehydrogenase in renal cell carcinoma: relationship between histological parameters and chemosensitivity to 5-fluorouracil. Eur Urol 43:45-51
    • (2003) Eur Urol , vol.43 , pp. 45-51
    • Hirano, Y.1    Takayama, T.2    Kageyama, S.3    Ushiyama, T.4    Suzuki, K.5    Fujita, K.6
  • 24
    • 0021040204 scopus 로고
    • Tumor heterogeneity in lung cancer based on light microscopic features. A retrospective study of a consecutive series of 200 patients, treated surgically
    • Hirsch FR, Ottesen G, Pødenphant J, Olsen J (1983) Tumor heterogeneity in lung cancer based on light microscopic features. A retrospective study of a consecutive series of 200 patients, treated surgically. Virchows Arch A Pathol Anat Histopathol 402:147-153
    • (1983) Virchows Arch A Pathol Anat Histopathol , vol.402 , pp. 147-153
    • Hirsch, F.R.1    Ottesen, G.2    Pødenphant, J.3    Olsen, J.4
  • 25
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us
    • Hlatky L, Hahnfeldt P, Folkman J (2002) Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 94:883-893
    • (2002) J Natl Cancer Inst , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 26
    • 0037439694 scopus 로고    scopus 로고
    • Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration
    • Hotchkiss KA, Ashton AW, Klein RS, Lenzi ML, Zhu GH, Schwartz EL (2003) Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration. Cancer Res 63:527-533
    • (2003) Cancer Res , vol.63 , pp. 527-533
    • Hotchkiss, K.A.1    Ashton, A.W.2    Klein, R.S.3    Lenzi, M.L.4    Zhu, G.H.5    Schwartz, E.L.6
  • 27
    • 34447341482 scopus 로고    scopus 로고
    • Mitotic control of dTTP pool: A necessity or coincidence?
    • Hu CM, Chang ZF (2007) Mitotic control of dTTP pool: a necessity or coincidence? J Biomed Sci 14:491-497
    • (2007) J Biomed Sci , vol.14 , pp. 491-497
    • Hu, C.M.1    Chang, Z.F.2
  • 30
    • 0032789998 scopus 로고    scopus 로고
    • Clinical significance of the detection of thymidine phosphorylase activity in esophageal squamous cell carcinomas
    • Ikeguchi M, Oka S, Saito H, Kondo A, Tsujitani S, Maeta M, Kaibara N (1999) Clinical significance of the detection of thymidine phosphorylase activity in esophageal squamous cell carcinomas. Eur Surg Res 31:357-363
    • (1999) Eur Surg Res , vol.31 , pp. 357-363
    • Ikeguchi, M.1    Oka, S.2    Saito, H.3    Kondo, A.4    Tsujitani, S.5    Maeta, M.6    Kaibara, N.7
  • 31
    • 0030704686 scopus 로고    scopus 로고
    • Human deoxycytidine kinase is located in the cell nucleus
    • Johansson M, Brismar S, Karlsson A (1997) Human deoxycytidine kinase is located in the cell nucleus. Proc Natl Acad Sci USA 94:11941-11945
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11941-11945
    • Johansson, M.1    Brismar, S.2    Karlsson, A.3
  • 32
    • 23944450180 scopus 로고    scopus 로고
    • Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability
    • Ke PY, Kuo YY, Hu CM, Chang ZF (2005) Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. Genes Dev 19:1920-1933
    • (2005) Genes Dev , vol.19 , pp. 1920-1933
    • Ke, P.Y.1    Kuo, Y.Y.2    Hu, C.M.3    Chang, Z.F.4
  • 33
    • 0027265154 scopus 로고
    • New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope
    • Key G, Becker MH, Baron B, Duchrow M, Schlüter C, Flad HD, Gerdes J (1993) New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Lab Invest 68:629-636
    • (1993) Lab Invest , vol.68 , pp. 629-636
    • Key, G.1    Becker, M.H.2    Baron, B.3    Duchrow, M.4    Schlüter, C.5    Flad, H.D.6    Gerdes, J.7
  • 34
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV (2006) Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66:8927-8930
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 35
    • 0034754268 scopus 로고    scopus 로고
    • Thymidine phosphorylase as a target for imaging and therapy with thymine analogs
    • Klecker RW Jr, Collins JM (2001) Thymidine phosphorylase as a target for imaging and therapy with thymine analogs. Cancer Chemother Pharmacol 48:407-412
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 407-412
    • Klecker Jr, R.W.1    Collins, J.M.2
  • 36
    • 0032951372 scopus 로고    scopus 로고
    • Immunohistochemical expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in squamous cell carcinoma of the esophagus
    • Koide N, Watanabe H, Yazawa K, Adachi W, Amano J (1999) Immunohistochemical expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in squamous cell carcinoma of the esophagus. Hepatogastroenterology 46:944-951
    • (1999) Hepatogastroenterology , vol.46 , pp. 944-951
    • Koide, N.1    Watanabe, H.2    Yazawa, K.3    Adachi, W.4    Amano, J.5
  • 37
    • 0026509422 scopus 로고
    • Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′- deoxythymidine
    • Kong XB, Zhu QY, Vidal PM, Watanabe KA, Polsky B, Armstrong D, Ostrander M, et al. (1992) Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′- deoxythymidine. Antimicrob Agents Chemother 36:808-818
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 808-818
    • Kong, X.B.1    Zhu, Q.Y.2    Vidal, P.M.3    Watanabe, K.A.4    Polsky, B.5    Armstrong, D.6    Ostrander, M.7
  • 38
    • 0033952360 scopus 로고    scopus 로고
    • Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
    • Koukourakis MI, Giatromanolaki A, Fountzilas G, Sivridis E, Gatter KC, Harris AL (2000) Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. Clin Cancer Res 6:381-389
    • (2000) Clin Cancer Res , vol.6 , pp. 381-389
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Fountzilas, G.3    Sivridis, E.4    Gatter, K.C.5    Harris, A.L.6
  • 39
    • 0031982381 scopus 로고    scopus 로고
    • Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: Impact on tumour neoangiogenesis and survival
    • Koukourakis MI, Giatromanolaki A, Kakolyris S, O'Byrne KJ, Apostolikas N, Skarlatos J, Gatter KC, et al. (1998) Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival. Br J Cancer 77:1696-1703
    • (1998) Br J Cancer , vol.77 , pp. 1696-1703
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Kakolyris, S.3    O'Byrne, K.J.4    Apostolikas, N.5    Skarlatos, J.6    Gatter, K.C.7
  • 40
    • 0031045574 scopus 로고    scopus 로고
    • Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer
    • Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Comley M, Whitehouse RM, Talbot DC, Gatter KC, et al. (1997) Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer. Br J Cancer 75:477-481
    • (1997) Br J Cancer , vol.75 , pp. 477-481
    • Koukourakis, M.I.1    Giatromanolaki, A.2    O'Byrne, K.J.3    Comley, M.4    Whitehouse, R.M.5    Talbot, D.C.6    Gatter, K.C.7
  • 41
    • 0035400379 scopus 로고    scopus 로고
    • Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase
    • Kuroiwa N, Nakayama M, Fukuda T, Fukui H, Ohwada H, Hiwasa T, Fujimura S (2001) Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase. J Immunol Methods 253:1-11
    • (2001) J Immunol Methods , vol.253 , pp. 1-11
    • Kuroiwa, N.1    Nakayama, M.2    Fukuda, T.3    Fukui, H.4    Ohwada, H.5    Hiwasa, T.6    Fujimura, S.7
  • 42
    • 0019856893 scopus 로고
    • Shedding of mitotic cells from the surface of multicell spheroids during growth
    • Landry J, Freyer JP, Sutherland RM (1981) Shedding of mitotic cells from the surface of multicell spheroids during growth. J Cell Physiol 106:23-32
    • (1981) J Cell Physiol , vol.106 , pp. 23-32
    • Landry, J.1    Freyer, J.P.2    Sutherland, R.M.3
  • 43
    • 20344369264 scopus 로고    scopus 로고
    • Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas
    • Li C, Shintani S, Terakado N, Klosek SK, Ishikawa T, Nakashiro K, Hamakawa H (2005) Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas. Int J Oral Maxillofac Surg 34:559-565
    • (2005) Int J Oral Maxillofac Surg , vol.34 , pp. 559-565
    • Li, C.1    Shintani, S.2    Terakado, N.3    Klosek, S.K.4    Ishikawa, T.5    Nakashiro, K.6    Hamakawa, H.7
  • 44
    • 35348944819 scopus 로고    scopus 로고
    • Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy
    • Liekens S, Bronckaers A, Pérez-Pérez MJ, Balzarini J (2007) Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy. Biochem Pharmacol 74:1555-1567
    • (2007) Biochem Pharmacol , vol.74 , pp. 1555-1567
    • Liekens, S.1    Bronckaers, A.2    Pérez-Pérez, M.J.3    Balzarini, J.4
  • 45
    • 0025351196 scopus 로고
    • Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas
    • Maehara Y, Moriguchi S, Emi Y, Watanabe A, Kohnoe S, Tsujitani S, Sugimachi K (1990) Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas. Cancer 66:156-161
    • (1990) Cancer , vol.66 , pp. 156-161
    • Maehara, Y.1    Moriguchi, S.2    Emi, Y.3    Watanabe, A.4    Kohnoe, S.5    Tsujitani, S.6    Sugimachi, K.7
  • 46
    • 25144508220 scopus 로고    scopus 로고
    • Expression of cell proliferating genes in patients with non-small cell lung cancer by immunohistochemistry and cDNA profiling
    • Mao Y, Wu J, Skog S, Eriksson S, Zhao Y, Zhou J, He Q (2005) Expression of cell proliferating genes in patients with non-small cell lung cancer by immunohistochemistry and cDNA profiling. Oncol Rep 13:837-846.
    • (2005) Oncol Rep , vol.13 , pp. 837-846
    • Mao, Y.1    Wu, J.2    Skog, S.3    Eriksson, S.4    Zhao, Y.5    Zhou, J.6    He, Q.7
  • 47
    • 0036422851 scopus 로고    scopus 로고
    • A comparative study: Immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer
    • Mao Y, Wu J, Wang N, He L, Wu C, He Q, Skog S (2002) A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer. Cancer Invest 20:922-931
    • (2002) Cancer Invest , vol.20 , pp. 922-931
    • Mao, Y.1    Wu, J.2    Wang, N.3    He, L.4    Wu, C.5    He, Q.6    Skog, S.7
  • 48
    • 0033214066 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas
    • Matsuura T, Kuratate I, Teramachi K, Osaki M, Fukuda Y, Ito H (1999) Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas. Cancer Res 59:5037-5040
    • (1999) Cancer Res , vol.59 , pp. 5037-5040
    • Matsuura, T.1    Kuratate, I.2    Teramachi, K.3    Osaki, M.4    Fukuda, Y.5    Ito, H.6
  • 50
    • 0030044995 scopus 로고    scopus 로고
    • Overexpression of thymidine kinase mRNA eliminates cell cycle regulation of thymidine kinase enzyme activity
    • Mikulits W, Hengstschläger M, Sauer T, Wintersberger E, Müllner EW (1996) Overexpression of thymidine kinase mRNA eliminates cell cycle regulation of thymidine kinase enzyme activity. J Biol Chem 271:853-860
    • (1996) J Biol Chem , vol.271 , pp. 853-860
    • Mikulits, W.1    Hengstschläger, M.2    Sauer, T.3    Wintersberger, E.4    Müllner, E.W.5
  • 51
    • 34247356159 scopus 로고    scopus 로고
    • Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
    • Miyake K, Imura S, Yoshizumi T, Ikemoto T, Morine Y, Shimada M (2007) Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer. Int J Clin Oncol 12:111-119
    • (2007) Int J Clin Oncol , vol.12 , pp. 111-119
    • Miyake, K.1    Imura, S.2    Yoshizumi, T.3    Ikemoto, T.4    Morine, Y.5    Shimada, M.6
  • 52
    • 24744438663 scopus 로고    scopus 로고
    • Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
    • Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, et al. (2005) Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med 11:992-997
    • (2005) Nat Med , vol.11 , pp. 992-997
    • Mizukami, Y.1    Jo, W.S.2    Duerr, E.M.3    Gala, M.4    Li, J.5    Zhang, X.6    Zimmer, M.A.7
  • 54
    • 0042924392 scopus 로고    scopus 로고
    • Quantitative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase in renal cell carcinoma
    • Morita T, Matsuzaki A, Tokue A (2003) Quantitative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase in renal cell carcinoma. Oncology 65:125-131
    • (2003) Oncology , vol.65 , pp. 125-131
    • Morita, T.1    Matsuzaki, A.2    Tokue, A.3
  • 55
    • 0020714345 scopus 로고
    • Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei
    • Noguchi H, Prem veer Reddy G, Pardee AB (1983) Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell 32:443-451
    • (1983) Cell , vol.32 , pp. 443-451
    • Noguchi, H.1    Prem veer Reddy, G.2    Pardee, A.B.3
  • 56
    • 0028961523 scopus 로고
    • Different angiogenic pathways characterize superficial and invasive bladder cancer
    • O'Brien T, Cranston D, Fuggle S, Bicknell R, Harris AL (1995) Different angiogenic pathways characterize superficial and invasive bladder cancer. Cancer Res 55:510-513
    • (1995) Cancer Res , vol.55 , pp. 510-513
    • O'Brien, T.1    Cranston, D.2    Fuggle, S.3    Bicknell, R.4    Harris, A.L.5
  • 57
    • 0029821907 scopus 로고    scopus 로고
    • Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers
    • O'Brien TS, Fox SB, Dickinson AJ, Turley H, Westwood M, Moghaddam A, Gatter KC, et al. (1996) Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers. Cancer Res 56:4799-4804
    • (1996) Cancer Res , vol.56 , pp. 4799-4804
    • O'Brien, T.S.1    Fox, S.B.2    Dickinson, A.J.3    Turley, H.4    Westwood, M.5    Moghaddam, A.6    Gatter, K.C.7
  • 58
    • 0034024352 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer
    • O'Byrne KJ, Koukourakis MI, Giatromanolaki A, Cox G, Turley H, Steward WP, Gatter K, et al. (2000) Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer. Br J Cancer 82:1427-1432
    • (2000) Br J Cancer , vol.82 , pp. 1427-1432
    • O'Byrne, K.J.1    Koukourakis, M.I.2    Giatromanolaki, A.3    Cox, G.4    Turley, H.5    Steward, W.P.6    Gatter, K.7
  • 59
    • 0036244343 scopus 로고    scopus 로고
    • Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome
    • Oudard S, Levalois C, Andrieu JM, Bougaran J, Validire P, Thiounn N, Poupon MF, et al. (2002) Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome. Anticancer Res 22:121-128
    • (2002) Anticancer Res , vol.22 , pp. 121-128
    • Oudard, S.1    Levalois, C.2    Andrieu, J.M.3    Bougaran, J.4    Validire, P.5    Thiounn, N.6    Poupon, M.F.7
  • 61
    • 0025126502 scopus 로고
    • JC70: A new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections
    • Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC, Mason DY (1990) JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 43:752-757
    • (1990) J Clin Pathol , vol.43 , pp. 752-757
    • Parums, D.V.1    Cordell, J.L.2    Micklem, K.3    Heryet, A.R.4    Gatter, K.C.5    Mason, D.Y.6
  • 62
    • 20144364091 scopus 로고    scopus 로고
    • Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages
    • Passantino L, Patruno R, Valerio P, Penna A, Mazzone F, Zito AF, Catalano V, et al. (2005) Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages. Immunopharmacol Immunotoxicol 27:95-107
    • (2005) Immunopharmacol Immunotoxicol , vol.27 , pp. 95-107
    • Passantino, L.1    Patruno, R.2    Valerio, P.3    Penna, A.4    Mazzone, F.5    Zito, A.F.6    Catalano, V.7
  • 63
    • 0034914078 scopus 로고    scopus 로고
    • Towards a genetic-based classification of human lung cancer
    • Petersen I, Petersen S (2001) Towards a genetic-based classification of human lung cancer. Anal Cell Pathol 22:111-121
    • (2001) Anal Cell Pathol , vol.22 , pp. 111-121
    • Petersen, I.1    Petersen, S.2
  • 65
    • 0025296739 scopus 로고
    • Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition
    • Plucinski TM, Fager RS, Reddy GP (1990) Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition. Mol Pharmacol 38:114-120
    • (1990) Mol Pharmacol , vol.38 , pp. 114-120
    • Plucinski, T.M.1    Fager, R.S.2    Reddy, G.P.3
  • 66
    • 0036732034 scopus 로고    scopus 로고
    • Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells
    • Rasey JS, Grierson JR, Wiens LW, Kolb PD, Schwartz JL (2002) Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. J Nucl Med 43:1210-1217
    • (2002) J Nucl Med , vol.43 , pp. 1210-1217
    • Rasey, J.S.1    Grierson, J.R.2    Wiens, L.W.3    Kolb, P.D.4    Schwartz, J.L.5
  • 68
    • 0041837649 scopus 로고    scopus 로고
    • Role of thymidine phosphorylase on invasiveness and metastasis in lung adenocarcinoma
    • Sato J, Sata M, Nakamura H, Inoue S, Wada T, Takabatake N, Otake K, et al. (2003) Role of thymidine phosphorylase on invasiveness and metastasis in lung adenocarcinoma. Int J Cancer 106:863-870
    • (2003) Int J Cancer , vol.106 , pp. 863-870
    • Sato, J.1    Sata, M.2    Nakamura, H.3    Inoue, S.4    Wada, T.5    Takabatake, N.6    Otake, K.7
  • 69
    • 0023951483 scopus 로고
    • Regulation of human thymidine kinase during the cell cycle
    • Sherley JL, Kelly TJ (1988) Regulation of human thymidine kinase during the cell cycle. J Biol Chem 263:8350-8358
    • (1988) J Biol Chem , vol.263 , pp. 8350-8358
    • Sherley, J.L.1    Kelly, T.J.2
  • 71
    • 0024357949 scopus 로고
    • Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of U-937 cells
    • Shiotani T, Hashimoto Y, Fujita J, Yamauchi N, Yamaji Y, Futami H, Bungo M, et al. (1989a) Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of U-937 cells. Cancer Res 49:6758-6763
    • (1989) Cancer Res , vol.49 , pp. 6758-6763
    • Shiotani, T.1    Hashimoto, Y.2    Fujita, J.3    Yamauchi, N.4    Yamaji, Y.5    Futami, H.6    Bungo, M.7
  • 72
    • 0024561343 scopus 로고
    • Behavior of activities of thymidine metabolizing enzymes in human leukemialymphoma cells
    • Shiotani T, Hashimoto Y, Tanaka T, Irino S (1989b) Behavior of activities of thymidine metabolizing enzymes in human leukemialymphoma cells. Cancer Res 49:1090-1094
    • (1989) Cancer Res , vol.49 , pp. 1090-1094
    • Shiotani, T.1    Hashimoto, Y.2    Tanaka, T.3    Irino, S.4
  • 74
    • 0031423080 scopus 로고    scopus 로고
    • NIR reflection measurements of hemoglobin and cytochrome aa3 in healthy tissue and tumors. Correlations to oxygen consumption: Preclinical and clinical data
    • Steinberg F, Röhrborn HJ, Otto T, Scheufler KM, Streffer C (1997) NIR reflection measurements of hemoglobin and cytochrome aa3 in healthy tissue and tumors. Correlations to oxygen consumption: preclinical and clinical data. Adv Exp Med Biol 428: 69-77
    • (1997) Adv Exp Med Biol , vol.428 , pp. 69-77
    • Steinberg, F.1    Röhrborn, H.J.2    Otto, T.3    Scheufler, K.M.4    Streffer, C.5
  • 75
    • 0029790295 scopus 로고    scopus 로고
    • Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma
    • Takebayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, et al. (1996a) Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88:1110-1117
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1110-1117
    • Takebayashi, Y.1    Akiyama, S.2    Akiba, S.3    Yamada, K.4    Miyadera, K.5    Sumizawa, T.6    Yamada, Y.7
  • 77
    • 33646589682 scopus 로고    scopus 로고
    • IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression
    • Tu Z, Prajapati S, Park KJ, Kelly NJ, Yamamoto Y, Gaynor RB (2006) IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression. J Biol Chem 281:6699-6706
    • (2006) J Biol Chem , vol.281 , pp. 6699-6706
    • Tu, Z.1    Prajapati, S.2    Park, K.J.3    Kelly, N.J.4    Yamamoto, Y.5    Gaynor, R.B.6
  • 78
    • 0037092979 scopus 로고    scopus 로고
    • Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    • Uchimiya H, Furukawa T, Okamoto M, Nakajima Y, Matsushita S, Ikeda R, Gotanda T, et al. (2002) Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose. Cancer Res 62:2834-2839
    • (2002) Cancer Res , vol.62 , pp. 2834-2839
    • Uchimiya, H.1    Furukawa, T.2    Okamoto, M.3    Nakajima, Y.4    Matsushita, S.5    Ikeda, R.6    Gotanda, T.7
  • 79
    • 0019025846 scopus 로고
    • Multienzyme complex for metabolic channeling in mammalian DNA replication
    • veer Reddy GP, Pardee AB (1980) Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci USA 77:3312-3316
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 3312-3316
    • veer Reddy, G.P.1    Pardee, A.B.2
  • 80
    • 0020580432 scopus 로고
    • Inhibitor evidence for allosteric interaction in the replitase multienzyme complex
    • veer Reddy GP, Pardee AB (1983) Inhibitor evidence for allosteric interaction in the replitase multienzyme complex. Nature 304:86-88
    • (1983) Nature , vol.304 , pp. 86-88
    • veer Reddy, G.P.1    Pardee, A.B.2
  • 81
    • 0021684233 scopus 로고
    • Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma
    • Vertongen F, Fondu P, van den Heule B, Cauchie C, Mandelbaum IM (1984) Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma. Tumour Biol 5:303-311
    • (1984) Tumour Biol , vol.5 , pp. 303-311
    • Vertongen, F.1    Fondu, P.2    van den Heule, B.3    Cauchie, C.4    Mandelbaum, I.M.5
  • 82
    • 34250684964 scopus 로고    scopus 로고
    • Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: New contrary data on prognostic role
    • Vesselle H, Freeman JD, Wiens L, Stern J, Nguyen HQ, Hawes SE, Bastian P, et al. (2007) Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: new contrary data on prognostic role. Clin Cancer Res 13:255-263
    • (2007) Clin Cancer Res , vol.13 , pp. 255-263
    • Vesselle, H.1    Freeman, J.D.2    Wiens, L.3    Stern, J.4    Nguyen, H.Q.5    Hawes, S.E.6    Bastian, P.7
  • 83
    • 0036847428 scopus 로고    scopus 로고
    • In vivo validation of 3′deoxy-3′-[(18)F] fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: Correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors
    • Vesselle H, Grierson J, Muzi M, Pugsley JM, Schmidt RA, Rabinowitz P, Peterson LM, et al. (2002) In vivo validation of 3′deoxy-3′-[(18)F] fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors. Clin Cancer Res 8:3315-3323
    • (2002) Clin Cancer Res , vol.8 , pp. 3315-3323
    • Vesselle, H.1    Grierson, J.2    Muzi, M.3    Pugsley, J.M.4    Schmidt, R.A.5    Rabinowitz, P.6    Peterson, L.M.7
  • 84
    • 3242681471 scopus 로고    scopus 로고
    • Relationship between non-small cell lung cancer fluorodeoxyglucose uptake at positron emission tomography and surgical stage with relevance to patient prognosis
    • Vesselle H, Turcotte E, Wiens L, Schmidt R, Takasugi JE, Lalani T, Vallières E, et al. (2004) Relationship between non-small cell lung cancer fluorodeoxyglucose uptake at positron emission tomography and surgical stage with relevance to patient prognosis. Clin Cancer Res 10:4709-4716
    • (2004) Clin Cancer Res , vol.10 , pp. 4709-4716
    • Vesselle, H.1    Turcotte, E.2    Wiens, L.3    Schmidt, R.4    Takasugi, J.E.5    Lalani, T.6    Vallières, E.7
  • 85
    • 0031732927 scopus 로고    scopus 로고
    • Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: Relationship to various biological factors
    • Volm M, Mattern J, Koomagi R (1998) Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors. Int J Oncol 13:975-979
    • (1998) Int J Oncol , vol.13 , pp. 975-979
    • Volm, M.1    Mattern, J.2    Koomagi, R.3
  • 86
    • 0019522434 scopus 로고
    • Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools
    • Weinberg G, Ullman B, Martin DW Jr (1981) Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools. Proc Natl Acad Sci USA 78:2447-2451
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 2447-2451
    • Weinberg, G.1    Ullman, B.2    Martin Jr, D.W.3
  • 87
    • 75749134146 scopus 로고
    • Epithelial tumours of the trachea, bronchi and lung
    • Butterworth, London
    • Willis RA (1948) Epithelial tumours of the trachea, bronchi and lung. In Pathology of Tumors. Butterworth, London
    • (1948) Pathology of Tumors
    • Willis, R.A.1
  • 88
    • 0034491670 scopus 로고    scopus 로고
    • A new cell proliferating marker: Cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma
    • Wu J, Mao Y, He L, Wang N, Wu C, He Q, Skog S (2000) A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma. Anticancer Res 20:4815-4820
    • (2000) Anticancer Res , vol.20 , pp. 4815-4820
    • Wu, J.1    Mao, Y.2    He, L.3    Wang, N.4    Wu, C.5    He, Q.6    Skog, S.7
  • 89
    • 15044357137 scopus 로고    scopus 로고
    • Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma
    • Yasuno M, Mori T, Koike M, Takahashi K, Toi M, Takizawa T, Shimizu S, et al. (2005) Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma. Oncol Rep 13:405-412
    • (2005) Oncol Rep , vol.13 , pp. 405-412
    • Yasuno, M.1    Mori, T.2    Koike, M.3    Takahashi, K.4    Toi, M.5    Takizawa, T.6    Shimizu, S.7
  • 90
    • 0023655202 scopus 로고
    • Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine- induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
    • Yoshioka A, Tanaka S, Hiraoka O, Koyama Y, Hirota Y, Ayusawa D, Seno T, et al. (1987) Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine- induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem 262:8235-8241
    • (1987) J Biol Chem , vol.262 , pp. 8235-8241
    • Yoshioka, A.1    Tanaka, S.2    Hiraoka, O.3    Koyama, Y.4    Hirota, Y.5    Ayusawa, D.6    Seno, T.7
  • 91
    • 0023813013 scopus 로고
    • Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy
    • Yusa T, Yamaguchi Y, Ohwada H, Hayashi Y, Kuroiwa N, Morita T, Asanagi M, et al. (1988) Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy. Cancer Res 48:5001-5006
    • (1988) Cancer Res , vol.48 , pp. 5001-5006
    • Yusa, T.1    Yamaguchi, Y.2    Ohwada, H.3    Hayashi, Y.4    Kuroiwa, N.5    Morita, T.6    Asanagi, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.