Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages

Immunopharmacology and Immunotoxicology

Volumn 27, Issue 1, 2005, Pages 95-107

  Passantino, L ^a   Patruno, R ^a   Valerio, P ^b   Penna, A ^c   Mazzone, F ^c   Zito, A F ^d   Catalano, V ^d   Pellecchia, A ^d   Jirillo, E ^a,c   Ranieri, Girolamo ^d  

^a UNIVERSITY OF BARI   (Italy)

^b DI VENERE HOSPITAL   (Italy)

^c Natl Institute of Digestive Disease   (Italy)

^d NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

5 Fluorouracile; Capecitabine; Immunohistochemistry; Pancreatic cancer; Platelet derived endothelial cell growth factor; Thymidine phosphorylase

Indexed keywords

CAPECITABINE; FLUOROPYRIMIDINE; FLUOROURACIL; THYMIDINE PHOSPHORYLASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER TISSUE; CLINICAL FEATURE; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PANCREAS; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

EID: 20144364091     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1081/IPH-51753     Document Type: Article

References (48)

1. Brown, N.S.; Bicknell, R. Thymidine phosphorylase, 2-deoxi-d-ribose and angiogenesis. Biochem. J. 1998, 334 (1), 1-8.
2. Friedkin, M.; Roberts, D. The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue. J. Biol. Chem. 1954, 207 (1), 245-256.
3. Friedkin, M.; Roberts, D. The enzymatic synthesis of nucleosides. II. Thymidine and related pyrimidine nucleosides. J. Biol. Chem. 1954, 207 (1), 257-266.
4. Blank, J.G.; Hoffee, P.A. Purification and properties of thymidine phosphorylase from Salmonella typhimurium. Arch. Biochem. Biophys. 1975, 168 (1), 259-265.
5. Kubilus, J.; Lee, L.D.; Baden, H.P. Purification of thymidine phosphorylase from human amniochorion. Biochim. Biophys. Acta 1978, 527 (1), 221-228.
6. Voytek, P. Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs. J. Biol. Chem. 1975, 250 (10), 3660-3665.
7. Patterson, A.V.; Talbot, D.C.; Stratford, I.J.; Harris, A.L. Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro. Cancer Res. 1998, 58 (13), 2737-2740.
8. Engels, K.; Fox, S.B.; Witehouse, R.M.; Gatter, K.C.; Harris, A.L. Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast. J. Pathol. 1997, 182 (4), 414-420.
9. Alcade, R.E.; Terakado, N.; Otsuki, K.; Matsumara, T. Angiogenesis and expression of platelet-derived endothelial cell growth factor in oral squamous cell carcinoma. Oncology 1997, 54 (4), 324-328.
10. Ranieri, G.; Labriola, A.; Achille, G.; Florio, G.; Zito, A.F.; Grammatica, L.; Paradiso, A. Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma. Int. J. Oncol. 2002, 21 (6), 1317-1323.
11. Ranieri, G.; Gasparini, G. Metastasis Research Protocols; Brooks Susan Press: Oxford, UK, 2001; 94-114.
12. Nakajima, Y.; Gotanda, T.; Uchimiya, H.; Furukawa, T.; Haraguchi, M.; Ikeda, R.; Sumizawa, T.; Yoshida, S.; Akiyama, H. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res. 2004, 64 (5), 1794-1801.
13. Sengupta, S.; Sellers, L.A.; Matheson, H.B.; Fan, T.P. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br. J. Pharmacol. 2003, 139 (2), 219-231.
14. Moghaddam, A.; Zhang, H.T.; Fan, T.P.D.; Hu, D.E.; Lees, V.C.; Turley, H.; Fox, S.B.; Gatter, K.C.; Harris, A.L.; Bicknell, R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc. Natl. Acad. Sci. U. S. A. 1995, 92 (4), 998-1002.
15. Fujimoto, K.; Hosotani, R.; Wada, M.; Lee, J.U.; Koshiba, T.; Miyamoto, Y.; Tsuji, S.; Nakajima, S.; Doi, R.; Imamura, M. Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis. Eur. J. Cancer 1998, 34 (9), 1439-1447.
16. Kuwahara, K.; Sasaki, T.; Kuwada, Y.; Murakami, M.; Yamasaki, S.; Chayama, K. Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. Pancreas 2003, 26 (4), 344-349.
17. Fujioka, S.; Yoshida, K.; Yanagisawa, S.; Kawakami, M.; Aoki, T.; Yamazaki, Y. Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival. Cancer 2001, 92 (7), 1788-1797.
18. Minari, Y.; Nio, Y.; Hirahara, N.; Dong, M. Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. Cancer Chemother. Pharmacol. 2001, 47 (5), 415-422.
19. Takao, S.; Takebayashi, Y.; Che, X.; Shinchi, H.; Natsugoe, S.; Miyadera, K.; Yamada, Y.; Akiyama, S.; Aikou, T. Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas. Clin. Cancer Res. 1998, 4 (7), 1619-1624.
20. Osada, S.; Saji, S.; Takahashi, T. A case report of papilla Vater carcinoma showing positive expression of thymidine phosphorylase. Hepatogastroenterology 2004, 51 (56), 375-377.
21. Biganzoli, L.; Martin, M.; Twelves, C. Moving forward with capecitabine: a glimpse of the future. Oncologist 2002, 7 (6), 29-35.
22. Twelves, C. Vision of the future: capecitabine. Oncologist 2001, 6 (4), 35-39.
23. Malet-Martino, M.; Martino, R. Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review. Oncologist 2002, 7 (4), 288-323.
24. Takebayashi, Y.; Yamada, K.; Miyadera, K.; Sumizawa, T.; Furukawa, T.; Kinoshita, F.; Aoki, D.; Okumura, H.; Yamada, Y.; Akiyama, S.; Aikou, T. The activity and expression of thymidine phosphorylase in human solid tumours. Eur. J. Cancer 1996, 32A (7), 1227-1232.
25. Takebayashi, Y.; Akiyama, S.; Akiba, S.; Yamada, K.; Miyadera, K.; Sumizawa, T.; Yamada, Y.; Murata, F.; Aikou, T. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J. Natl. Cancer Inst. 1996, 88 (16), 1110-1117.
26. Pentheroudakis, G.; Twelves, C. The rational development of capecitabine from the laboratory to the clinic. Anticancer Res. 2002, 22 (6B), 3589-3596.
27. Morita, T.; Matsuzaki, A.; Suzuki, K.; Tokue, A. Role of thymidine phosphorylase in biomodulation of fluoropyrimidines. Curr. Pharm. Biotechnol. 2001, 2 (3), 257-267.
28. Sobin, L.H.; Fleming, I.D. TNM classification of malignant tumours, 5th Ed. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997, 80 (9), 1803-1804.
29. Ranieri, G.; Patruno, R.; Fiore, G.; Saponaro, G.; Paradiso, A.; Grammatica, L. Thymidine phosphorylase over-expression in oral squamous carcinoma tissue as a potential target of capecitabine. Lett. Drug Design Disc. 2004, 1, 45-49.
30. Weidner, N.; Semple, J.P.; Welch, W.R.; Folkman, J. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N. Engl. J. Med. 1991, 324 (1), 1-8.
31. Ranieri, G.; Passantino, L.; Patruno, R.; Passantino, G.; Jirillo, F.; Catino, A.; Mattioli, V.; Gadaleta, C.; Ribatti, D. The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy. Oncol. Rep. 2003, 10 (5), 1189-1193.
32. van Overveld, F.J.; Bruijnzeel, P.L.; Kreukniet, J.; Raaijmakers, J.A.; Terpstra, G.K. The isolation of inflammatory cells from normal human lung tissue. Int. J. Tissue React. 1987, 9 (1), 61-67.
33. Saxena, R.K.; Weissman, D.; Simpson, J.; Lewis, D.M. Murine model of BCG lung infection: dynamics of lymphocyte subpopulations in lung interstitium and tracheal lymph nodes. Bioscience 2002, 27 (2), 143-153.
34. Wakeham, J.; Wang, J.; Magram, J.; Croitoru, K.; Harkness, R.; Dunn, P.; Zganiacz, A.; Xing, Z. Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guerin in IL-12-deficient mice. J. Immunol. 1998, 160 (12), 6101-6111.
35. Caradonna, L.; Mastronardi, M.L.; Magrone, T.; Cozzolongo, R.; Cuppone, R.; Manghisi, O.G.; Caccavo, D.; Pellegrino, N.M.; Amoroso, A.; Jirillo, E.; Amati, L. Biological and clinical significance of endotoxemia in the course of hepatitis C virus infection. Curr. Pharm. Des. 2002, 8 (11), 995-1005.
36. Sengupta, S.; Sellers, L.A.; Matheson, H.B.; Fan, T.P. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br. J. Pharmacol. 2003, 139 (2), 219-231.
37. Ishikawa, F.; Miyazono, K.; Hellman, U.; Drexler, H.; Wernstedt, C.; Hagiwara, K.; Usuki, K.; Takaku, F.; Risau, W.; Heldin, C.H. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 1989, 338 (6216), 557-562.
38. Khan, A.W.; Dhillon, A.P.; Hutchins, R.; Abraham, A.; Shah, S.R.; Snooks, S.; Davidson, B.R. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. Eur. J. Surg. Oncol. 2002, 28 (6), 637-644.
39. Kuehn, R.; Lelkes, P.I.; Bloechle, C.; Niendorf, A.; Izbicki, J.R. Angiogenesis, angiogenic growth factors, and cell adhesion molecules are upregulated in chronic pancreatic diseases: angiogenesis in chronic pancreatitis and in pancreatic cancer. Pancreas 1999, 18 (1), 96-103.
40. Esposito, I.; Menicagli, M.; Funel, N.; Bergmann, F.; Boggi, U.; Mosca, F.; Bevilacqua, G.; Campani, D. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J. Clin. Pathol. 2004, 57 (6), 630-636.
41. Giatromanolaki, A.; Koukourakis, M.I.; Comley, M.; Kaklamanis, L.T.H.; O'Byrne, K.; Harris, A.L.; Gatter, K.C. Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer. J. Pathol. 1997, 181 (2), 196-199.
42. Nagaoka, H.; Iino, Y.; Takei, H.; Morishita, Y. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in macrophages correlates with tumor angiogenesis and prognosis in invasive breast cancer. Int. J. Oncol. 1998, 13 (3), 449-454.
43. Zhu, G.H.; Schwartz, E.L. Expression of the angiogenic factor thymidine phosphorylase in THP-1 monocytes: induction by autocrine tumor necrosis factor-alpha and inhibition by aspirin. Mol. Pharmacol. 2003, 64 (5), 1251-1258.
44. Hotchkiss, K.A.; Ashton, A.W.; Klein, R.S.; Lenzi, M.L.; Zhu, G.H.; Schwartz, E.L. Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration. Cancer Res. 2003, 63 (2), 527-533.
45. Toi, M.; Hoshina, S.; Taniguchi, T.; Yamamoto, Y.; Ishitsuka, H.; Tominaga, T. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int. J. Cancer 1995, 64 (2), 79-82.
46. Fox, S.B.; Westwood, M.; Moghaddam, A.; Comley, M.; Turley, H.; Whitehouse, R.M.; Bicknell, R.; Gatter, K.C.; Harris, A.L. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. Br. J. Cancer 1996, 73 (3), 275-280.
47. Nagaoka, H.; Iino, Y.; Takei, H.; Morishita, Y. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in macrophages correlates with tumor angiogenesis and prognosis in invasive breast cancer. Int. J. Oncol. 1998, 13 (3), 449-454.
48. Kerbel, R.S.; Viloria-Petit, A.; Rak, J. 'Accidental' anti-angiogenic drugs: anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples. Eur. J. Cancer 2000, 36 (10), 1248-1257.