Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes

Journal of Controlled Release

Volumn 87, Issue 1-3, 2003, Pages 167-176

  Van Steenis, J H ^a   Van Maarseveen, E M ^a   Verbaan, F J ^a   Verrijk, R ^b   Crommelin, D J A ^a,b   Storm, G ^a   Hennink, W E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b OctoPlus NV   (Netherlands)

Author keywords

Folate; Gene delivery; pEG; Polyplex; Tumor targeting

Indexed keywords

COPOLYMER; FOLIC ACID DERIVATIVE; MACROGOL; METHACRYLIC ACID METHYL ESTER;

CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANALYSIS; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CANCER; PARTICLE SIZE; PRIORITY JOURNAL; ZETA POTENTIAL;

DRUG DELIVERY SYSTEMS; FOLIC ACID; HUMANS; METHACRYLATES; NYLONS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037458923     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00361-9     Document Type: Conference Paper

References (29)

1. Sudimack J., Lee R.J. Targeted drug delivery via the folate receptor. Adv. Drug Deliv. Rev. 41:2000;147-162.
2. Corona G., Giannini F., Fabris M., Toffoli G., Boiocchi M. Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells. Int. J. Cancer. 75:1998;125-133.
3. Stella B., Arpicco S., Peracchia M.T., Desmaële D., Hoebeke J., Renoir M.J., d'Angelo J., Cattel L., Couvreur P. Design of folic acid-conjugated nanoparticles for drug targeting. J. Pharm. Sci. 89:2000;1452-1464.
4. De Smedt S.C., Demeester J., Hennink W.E. Cationic polymer based gene delivery systems. Pharm. Res. 17:2000;113-126.
5. Ward C.M. Folate-targeted non-viral DNA vectors for cancer gene therapy. Curr. Opin. Mol. Ther. 2:2000;182-187.
6. Wang S., Lee R.J., Cauchon G., Gorenstein D.G., Low P.S. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci. USA. 92:1995;3318-3322.
7. Lee R.J., Huang L. Folate-targeted anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 27:1996;8481-8487.
8. Reddy J.A., Low P.S. Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation. J. Control. Release. 64:2000;27-37.
9. Mislick K.A., Baldeschwieler J.D., Kayyem J.F., Meade T.J. Transfection of folate-polylysine DNA complexes: Evidence for lysosomal delivery. Bioconjug. Chem. 6:1995;512-515.
10. Leamon C.P., Weigl D., Hendren R.W. Folate copolymer-mediated transfection of cultured cells. Bioconjug. Chem. 10:1999;947-957.
11. Guo W., Lee R.J. Receptor-targeted gene delivery via folate conjugated polyethylenimine [article 19: http://www.pharmsci.org ]. AAPS Pharmsci. 1:1999;19.
12. Benns J.M., Maheshwari A., Furgeson D.Y., Mahato R.I., Kim S.W. Folate-PEG-folate-graft-polyethylenimine-based gene delivery. J. Drug Target. 9:2001;123-139.
13. Benns J.M., Mahato R.I., Kim S.W. Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J. Control. Release. 79:2002;255-269.
14. Lee R.J., Low P.S. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J. Biol. Chem. 269:1994;3198-3204.
15. Choi Y.H., Liu F., Kim J.-S., Choi Y.K., Park J.S., Kim S.W. Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. J. Control. Release. 54:1998;39-48.
16. F.J. Verbaan, C. Oussoren, A.M. Funhoff, C.J. Snel, D.J.A. Crommelin, W.E. Hennink, G. Storm, Steric stabilization of pDMAEMA-based polyplexes mediates prolonged circulation and tumor targeting in mice, in preparation.
17. Ogris M., Brunner S., Schüller S., Kircheis R., Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6:1999;595-605.
18. Erbacher P., Bettinger T., Belguise-Valladier P., Zou S., Coll J.-L., Behr J.-P., Remy J.-S. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI). J. Gene Med. 1:1999;210-222.
19. Zuidam N.J., Posthuma G., de Vries E.T.J., Crommelin D.J.A., Hennink W.E., Storm G. Effects of physicochemical characteristics of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes on cellular association and internalization. J. Drug Target. 8:2000;51-66.
20. Blessing T., Kursa M., Holzhauser R., Kircheis R., Wagner E. Different strategies for formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug. Chem. 12:2001;529-537.
21. van de Wetering P., Cherng J.Y., Talsma H., Crommelin D.J.A., Hennink W.E. 2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J. Control. Release. 53:1998;145-153.
22. van de Wetering P., Schuurmans-Nieuwenbroek N.M.E., Hennink W.E., Storm G. Comparative transfection studies of human ovarian carcinoma cells in vitro, ex vivo and in vivo with poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. J. Gene Med. 1:1999;156-165.
23. Verbaan F.J., Oussoren C., van Dam I.M., Takakura Y., Hashida M., Crommelin D.J., Hennink W.E., Storm G. The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration. Int. J. Pharm. 214:2001;99-101.
24. Mastrobattista E., Kapel R.H., Eggenhuisen M.H., Roholl P.J., Crommelin D.J.A., Hennink W.E., Storm G. Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells. Cancer Gene Ther. 8:2001;405-413.
25. van Dijk-Wolthuis W.N.E., van de Wetering P., Hinrichs W.L.J., Hofmeyer L.J.F., Liskamp R.M.J., Crommelin D.J.A., Hennink W.E. A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate]. Bioconjug. Chem. 10:1999;687-692.
26. Cherng J.Y., van de Wetering P., Talsma H., Crommelin D.J.A., Hennink W.E. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res. 13:1996;1038-1042.
27. Hamilton T.C., Young R.C., McKoy W.M., Grotzinger K.R., Green J.A., Chu E.W., Whang-Peng J., Rogan A.M., Green W.R., Ozols R.F. Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors. Cancer Res. 43:1983;5379-5389.
28. Morgan D.M., Larvin V.L., Pearson J.D. Biochemical characterisation of polycation-induced cytotoxicity to human vascular endothelial cells. J. Cell Sci. 94:1989;553-559.
29. Morgan D.M., Clover J., Pearson J.D. Effects of synthetic polycations on leucine incorporation, lactate dehydrogenase release, and morphology of human umbilical vein endothelial cells. J. Cell Sci. 91:1988;231-238.